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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 3 | Comparison of the chemical changes in the rhizosphere of the nickel hyperaccumulator Alyssum murale with the nonaccumulator Raphanus sativus显示文摘 | Bernal M P McGrath S P Miller A J | 1994 | Plant and Soil1994，164，： | 1 |
| 4 | Parent-child interaction therapy for Puerto Rican preschool children with ADHD and behavior problems: a pilot efficacy study显示文摘 | Matos M Bauermeister J J Bernal G | 2009 | Faro Process2009，48，2： | 1 |
| 5 | Determination of rotenone residues in raw honey by solid-phase extraction and high-performance liquid chromatography 显示文摘 | Jimenez J J Bernal J L Del M J | 2000 | J Chromatogr A2000，871，12： | 1 |
| 6 | Trace ele- ment behaviour at the root-soil interface: Implications in phytoremediation显示文摘 | KIDD P BARCELO J BERNAL M P | 2009 | Eviron Exp Bot2009，67，： | 1 |
| 7 | Resistance in plants transformed with the P1 or P3 gene of to- bacco vein mottling potyvirus显示文摘 | Moreno M Bernal J J Jim6nez I | 1998 | Journal of Gen- eral Virology1998，79，11： | 1 |
| 8 | Acute liver failure: clinical and management显示文摘 | Bernal W Wendon J | 1999 | Eur J Gastroenterol Hepatol1999，11，9： | 1 |
| 9 | Growth and electron field-emission of single-crystal line ZnO nanowires显示文摘 | MOSQUERA E BERNAL J ZARATE R A | 2013 | Mater Lett2013，93，： | 1 |
| 10 | A new collabora- tive filtering metric that improves the behavior of recommender sys- tems 显示文摘 | BOBADILLA J SERRADILLA F BERNAL J | 2010 | Knowledge-Based Systems2010，23，6： | 1 |
| 11 | Fruit development in Capsicum annuum: Changes in capsaicin, lignin, free phenolics, and peroxidase patterns显示文摘 | Bernal M A Diaz J | 2000 | J Agic Food Chem2000，48，： | 1 |
| 12 | Acute liver failure: clinical features and menagement 显示文摘 | Bernal W Wendon J | 1999 | Eur J Gastroenterol Hepatol1999，11，9： | 1 |
| 13 | Shredded tires and rubber sand as lightweight backfill显示文摘 | LEE J H SALGADO R BERNAL A | 1999 | Journal of Geotechnical and Geoenvironmental Engineering1999，125，2： | 1 |
| 14 | Pathogenicity islands and virulence eveluation Listeria显示文摘 | Vazquez Boland J A Dominguiz Bernal G Gonzalez Zorn B | 2001 | Microbes and Infection2001，69，： | 1 |
| 15 | Association of tumor necrosis factor polymorphism with primary sclerosing cholangitis显示文摘 | Bernal W Moloney M Underhill J | 1999 | J Hepatol1999，30，2： | 1 |
| 16 | A geometrical approach to the structure of liquid显示文摘 | Bernal J | 1959 | Nature1959，183，17： | 1 |
| 17 | Drought advances spring growth phenology of the Mediterranean shrub Erica multiflora 显示文摘 | Bernal M Estiarte M Pefluelas J | 2011 | Plant Biol2011，13，： | 1 |
| 18 | Separation of albendazole sulfoxlde enantiomers by chiral supercritical-fluid chromatography 显示文摘 | Nozal M J Toribio L Bernal JL | 2002 | J Biochem Biophys Methods2002，54，13： | 1 |
| 19 | Argyrophilic nucleolar organizer region (AgNOR) counting in astrocytic gliomas : prognostic value 显示文摘 | FERRERES JC FIGOLS J VAL - BERNAL JF | 1996 | Histol Histopathol1996，11，1： | 1 |
| 20 | Differential vulnerability of hippocampus,basal ganglia,and prefrontal cortex to long-term NMDA excitotoxicity显示文摘 | Bernal F Saura J Ojuel J | 2000 | Exp Neurol2000，161，2： | 1 |
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