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| 1 | The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection显示文摘This review describes the woodchuck and the woodchuck hepatitis virus (WHV) as an animal model for pathogenesis and therapy of chronic hepatitis B virus (HBV) infection and disease in humans. The establishment of woodchuck breeding colonies, and use of laboratory-reared woodchucks infected with defined WHV inocula, have enhanced our understanding of the virology and immunology of HBV infection and disease pathogenesis, including major sequelae like chronic hepatitis and hepatocellular carcinoma. The role of persistent WHV infection and of viral load on the natural history of infection and disease progression has been firmly established along the way. More recently, the model has shed new light on the role of host immune responses in these natural processes, and on how the immune system of the chronic carrier can be manipulated therapeutically to reduce or delay serious disease sequelae through induction of the recovery phenotype. The woodchuck is an outbred species and is not well defined immunologically due to a limitation of available host markers. However, the recent development of several key host response assays for woodchucks provides experimental opportunities for further mechanistic studies of outcome predictors in neonatal- and adult-acquired infections. Understanding the virological and immunological mechanisms responsible for resolution of self-limited infection, andfor the onset and maintenance of chronic infection, will greatly facilitate the development of successful strategies for the therapeutic eradication of established chronic HBV infection. Likewise, the results of drug efficacy and toxicity studies in the chronic carrier woodchucks are predictive for responses of patients chronically infected with HBV. Therefore, chronic WHV carrier woodchucks provide a well-characterized mammalian model for preclinical evaluation of the safety and efficacy of drug candidates, experimental therapeutic vaccines, and immunomodulators for the treatment and prevention of HBV disease sequelae. | Stephan Menne Paul J Cote | 2007 | World Journal of Gastroenterology2007，13，1： | 22 |
| 2 | Gas–metal reaction products in the erosion of chromium-plated gun bores显示文摘 | Paul J Cote Christopher Rickard | 2000 | Wear2000，，1： | 2 |
| 3 | New directions in management accounting research 显示文摘 | Atkinson A A Balakrishnan P B Cote J M Grout T M Roberts H Ulan E Wu A | | Journal of Management Accounting Research0，997，： | 1 |
| 4 | Increasing N and P resorption effi- ciency and proficiency in northern deciduous hardwoods with decrea- sing foliar N and P concentrations 显示文摘 | Cote B Fyles J W Djalivand H | 2002 | Annals of forest science2002，59，3： | 1 |
| 5 | Laserpulse heating of gun bore coatings显示文摘 | COTE P J KENDALL G TODARO M E | 2001 | Surface CoatingTechnology2001，，： | 1 |
| 6 | Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase -4 inhibitor显示文摘 | Bergman A J Cote J Yi B | 2007 | Diabetes Care2007，30，7： | 1 |
| 7 | A proteomic analysis of arginine-methylated protein complexes 显示文摘 | Boisvert FM Cote J Boulanger MC | 2003 | Mol Cell Proteomics2003，2，12： | 1 |
| 8 | Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts 显示文摘 | ANGERS-LOUSTAU A COTE J F CHAREST A | 1999 | Cell Biol1999，144，5： | 1 |
| 9 | Defining consumer satisfaction 显示文摘 | Giese J L Cote J A | 2000 | Academy of Marketing Science Review2000，18，1： | 1 |
| 10 | Impact of gauze-based NPWT on the patient and nursing experience in the treatment of challenging wounds显示文摘 | Hurd T Chadwick P Cote J | 2010 | Int Wound J2010，7，1： | 1 |
| 11 | Organizing and interpreting unstructured qualitative data显示文摘 | Cote J Salmela J Baria A | 1993 | The Sport Psychol1993，7，2： | 1 |
| 12 | The exercise of interfirm power and its repercussions in US-Japanese channel rela- tionships显示文摘 | Johnson J L Sakano T Cote J A | 1993 | Journal of Marketing1993，57，2： | 1 |
| 13 | Racial differ- ences in oncogene mutations detected in early-stage low- grade endometrial cancers 显示文摘 | Cote ML Atikukke G Ruterbusch J J | 2012 | Int J Gynecol Cancer2012，22，8： | 1 |
| 14 | Near wins prolong gambling on a video lottery terminal显示文摘 | Cote D Caron A Aubert J | 2003 | Journal of Gambling Studies2003，19，4： | 1 |
| 15 | Gasmetal reaction products inthe erosion of chromiumplated gun bores 显示文摘 | COTE P J RICKARD C | 2000 | Wear2000，214，1： | 1 |
| 16 | Defining Consumer Satisfaction显示文摘 | Giese J L Cote J A | 2013 | Academy of Marketing Science Review2013，1，1： | 1 |
| 17 | The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease 显示文摘 | CELLI B R COTE C G MARIN J M | 2004 | N Engl J Med2004，350，10： | 1 |
| 18 | The Highly Conserved and Multifunctional NuA4 HAT Complex显示文摘 | Cote J | 2004 | Curr Opin Genet Dev2004，14，： | 1 |
| 19 | The MYST family of histone acetyhransferases 显示文摘 | Utley R T Cote J | 2003 | Curr Top Microbiol Immunol2003，274，： | 1 |
| 20 | Detection of occult bone marrow micrometastases in patients with operable lung carcinoma显示文摘 | Cote R J Mllar T Ormerod M G | 1995 | Ann Surg1995，222，4： | 1 |
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