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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Barry J Shelp Alan W Bown Michael D McLean | 1999 | Trends in Plant Science1999，，11： | 2 |
| 4 | The Chase Family of Detection Algorithms for Multiple-input Multiple-output Channels 显示文摘 | WATERS D W BARRY J R | 2004 | IEEE GLOBECOM2004，，4： | 1 |
| 5 | Linear signal synthesis using the Radon-Wigner transform显示文摘 | WOOD J C BARRY D T | 1994 | IEEE Trans on Signal Processing1994，42，9： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | Acid mine drainage remediation options a review 显示文摘 | BARRIE J D KEVIN B H | 2005 | Science of the Total Environment2005，338，： | 1 |
| 8 | Application ofcomputed global radiation for areas of high relief 显示文摘 | Williams L D Barry R G Andrews J T | 1972 | Journal of Applied Meteorology1972，，11： | 1 |
| 9 | The Automatic Recognition and Counting of Cough显示文摘 | Barry S J Dane A D Morice A H | 2006 | Cough2006，2，1： | 1 |
| 10 | Radon transformation of time-frequency distributions for analysis of multi-component signals显示文摘 | Wood J C Barry D T | 1994 | IEEE Trans on Signal Processing1994，42，11： | 1 |
| 11 | Critical interplay be- tween parasite differentiation, host immunity, and antigenic variation in trypanosome infections显示文摘 | GJINI E HAYDON D T BARRY J D | 2010 | Am Nat2010，176，4： | 1 |
| 12 | Correlation of B-type natriuretic peptide level to 6-min walk test performance in patients with left ventricu- lar systolic dysfunction 显示文摘 | Wieczorek S J Hager D Barry MB | 2003 | Clin Chim Acta2003，328，12： | 1 |
| 13 | Observations on chip formation and acoustic emission machining Ti-6A1-4V alloy显示文摘 | Barry J Byrne G Lennon D | 2001 | Internaltonal Journal of Machine Tools and Manufacture2001，41，： | 1 |
| 14 | New and Selective Ryanodine Receptor Activators for Insect Control显示文摘 | Lahm G P Cordova D Barry J D | 2009 | Bioorganic & Medicinal Chemistry2009，17，12： | 1 |
| 15 | New and selective ryanodine receptor activators for insect control显示文摘 | LAHM G P CORDOVA D BARRY J D | 2009 | Bioorg & Med Chem2009，17，： | 1 |
| 16 | An Improved Algorithm for the Generation of Nonparametric Curves显示文摘 | Bernard W J William J L Barry D H | 1976 | Ieee Transactinos On Computers1976，22，12： | 1 |
| 17 | Parameter and process significance in mechanistic modeling of cellulose hydrolysis显示文摘 | Rotter B E Barry D A Gerhard J I Small J S | 2009 | Bioresource Technol2009，99，13： | 1 |
| 18 | γ-Alumina nanofi bers prepared from aluminum hydrate with poly(ethylene oxide)surfactant显示文摘 | Zhu H Y Riches J D Barry J C | 2002 | Chem Mater2002，14，： | 1 |
| 19 | Application of computed global radiation for areas of high relief显示文摘 | WILLIAMS L D BARRY R G ANDREWS J T | 1972 | Journal of Applied Meteorology1972，，11： | 1 |
| 20 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
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