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310篇 您的检索式：作者名="J Erdmann"

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	题名	作者	年代	出处	被引量
1	Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.	Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser	2009	World Journal of Gastroenterology2009，15，35：	7
2	beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin 显示文摘	Huelsken J Vogel R Erdmann B	2001	Cell2001，105，4：	1
3	Design of antisense oligonucleotides stabilized by locked nucleic acids显示文摘	KURRECK J WYSZKO E GILLEN C ERDMANN V A	2002	Nucleic Acid Res2002，30，9：	1
4	A yeast-based functional assay for the detection of the mutant androgen receptor in prostate cancer 显示文摘	Ceraline J Erdmann E Erbs P	2003	Eur J Endocrinol2003，148，1：	1
5	Diagnostic tests based on human basophils : potentials, pitfalls and perspectives 显示文摘	Kleine-Tebbe J Erdmann S Knol E F	2006	Int Arch Allergy Immunol2006，141，1：	1
6	The effect of cardiacresynchronization on morbidity and mortality in heart failure显示文摘	Cleland J G Daubert J C Erdmann E	2005	N Engl JMed2005，352，15：	1
7	beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin显示文摘	Huelsken J Vogel R Erdmann B	2001	Cell2001，105，4：	1
8	beta-Catenin controls hair fol- licle morphogenesis and stem cell differentiation in the skin显示文摘	Huelsken J Vogel R Erdmann B	2001	Cell2001，105，4：	1
9	Beta-catenin controls hair follicle mophogenesis and cell differentiation in the skin 显示文摘	Huelsken J Vogel R Erdmann B	2001	Mol Cell2001，105，4：	1
10	Polymorphisms in the promoter region of the dimethylarginine dimethylaminohy- drolase 2 gene are associated with prevalence of hypertension显示文摘	MAAS R ERDMANN J L?NEBURG N	2009	Pharmacol Res2009，60，6：	1
11	Genome-wide haplotype association study identifies the SLC22A3-LPAL2- LPA gene cluster as a risk locus for coronary artery disease 显示文摘	Tr6gou~t DA K~nig IR Erdmann J	2009	Nat Genet2009，41，3：	1
12	Beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin 显示文摘	Vogel R Erdmann B Cotsarelis G Birchmeier W	2001	Cell2001，，4：	1
13	β-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin显示文摘	Vogel R Erdmann B	2001	Cell2001，105，：	1
14	Novel mutation in theα-tropomyosin gene and transition from hypertrophic to hypocontractile dilated cardiomyopathy 显示文摘	Regitz-Zagrosek V Erdmann J Wellnofer E	2000	Circulation2000，102，：	1
15	Differ- ential effect of protein and fat on plasma ghrelin levels in man显示文摘	ERDMANN J LIPPL F SCHUSDZIARRA V	2003	Regulatory Peptides2003，116，123：	1
16	Novel mutations in sar-comeric protein genes in dilated cardiomyopathy 显示文摘	Daehmlow S Erdmann J Knueppel T	2002	Biochem Bio- phys Res Commun2002，298，：	1
17	The effect of cardiac resynchronization on morbidity and mortality in heart failure显示文摘	CLELAND J G DAUBERT J C ERDMANN E	2005	N Engl J Med2005，352，15：	1
18	The effect of cardiac resynchronization on morbidity and mortality in heart failure显示文摘	Cleland J G Daubert J C Erdmann E		0，，15：	1
19	Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection显示文摘	Erdmann M D6rrie J Schaft N	2007	J Immunother2007，30，6：	1
20	Isotopic composition of nitrogen in Stomatopod (Crustaeea) tissues as an indicator of human sewage impacts on Indonesian coral reefs 显示文摘	Risk M J Erdmann M V	2000	Marine Pollution Bulletin2000，40，1：	1

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