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| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | 在没有危险因素的情况下,正常的低密度脂蛋白胆固醇水平与亚临床动脉粥样硬化相关显示文摘普遍认为缺乏心血管病危险因素(cardiovascular risk factors,CVRF)人群的动脉粥样硬化发生风险低,然而,无CVRF的个体仍然有心血管事件发生。为了确定无CVRF个体中亚临床动脉粥样硬化的预测因子, | Fernández-Friera L Fuster V López-Melgar B Oliva B García-Ruiz JM Mendiguren J Bueno H Pocock S Ibánez B Fernández-Ortiz A Sanz J 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 17 |
| 3 | Pancreatic pseudocyst drainage guided by endoscopic ultrasound显示文摘Pancreatic pseudocysts can be managed conservatively in the majority of patients but some of them will require surgical,endoscopic or percutaneous drainage. Endoscopic drainage represents an efficient modality of drainage with a high resolution rate and lower morbidity and mortality than the surgical or percutaneous approach.In this article we review the endoscopic pseudocyst drainage procedure with special emphasis on technical details. | Juan J Vila David Carral Ignacio Fernández-Urien | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，6： | 6 |
| 4 | Gallbladder tuberculosis: False-positive PET diagnosis of gallbladder cancer显示文摘Gallbladder tuberculosis (GT) is an extremely rare disease, and very few cases have been reported in the literature. The first case of GT was described in 1870 by Gaucher. A correct preoperative diagnosis of GT is unusual, and it is frequently confused with various gallbladder diseases. We present a new case of a patient who underwent surgery with the preoperative diagnosis of gallbladder cancer after a false positive positron emission tomography scan in the diagnostic work-up. | JM Ramia K Muffak A Fernández J Villar D Garrote JA Ferron | 2006 | World Journal of Gastroenterology2006，12，40： | 5 |
| 5 | Endoscopic and anesthetic feasibility of EUS and ERCP combined in a single session versus two different sessions显示文摘AIM:To discuss the feasibility of single session endoscopic ultrasonography(EUS) to discuss and endoscopic retrograde cholangiopancreatography(ERCP) execution.METHODS:Retrospective endoscopic and anesthetic outcome comparison of performing both EUS and ERCP in a single endoscopic session(Group Ⅰ) versus performing each procedure in two different sessions(Group Ⅱ) was made.The following variables were evaluated:epidemiological variables,American Society of Anesthesiologists Physical Status Classification(ASA) level,procedural time,propofol dose,anesthetic complications,endoscopic complications and diagnostic yield,and therapeutic procedures on both groups.T-student,ChiSquare and Fisher test were used for comparison.RESULTS:We included 39 patients in Group Ⅰ(mean age:69.85 ± 9.25;27 men) and 46 in Group Ⅱ(mean age:67.46 ± 12.57;25 men).Procedural time did not differ significantly between both groups(Group Ⅰvs Group Ⅱ:93 ± 32.78 vs 98.98 ± 38.17;P >0.05) but the dose of propofol differed(Group Ⅰ vs Group Ⅱ:322.28 ± 250.54 mg vs 516.96 ± 289.06 mg;P = 0.001).Three patients had normal findings on both explorations.Three anesthetic complications [O2 desaturation(2),broncoaspiration(1)] and 9 endoscopic complications [pancreatitis(6),bleeding(1),perforation(1),cholangitis(1)] occurred without significant differences between both groups(P > 0.05).We did not find any significant difference regarding age,sex,ASA scale level,diagnostic yield or therapeutic maneuvers between both groups.CONCLUSION:The performance of EUS and ERCP in a single session offers a similar diagnostic and therapeutic yield,does not entail a higher complication risk and requires a significantly smaller dose of propofol for sedation compared with performing each exploration in a different session. | Juan J Vila Marcos Kutz Silvia Goi Miriam Ostiz Edurne Amorena Carlos Prieto Cristina Rodriguez Ignacio Fernández-Urien Francisco J Jiménez | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 3 |
| 6 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 7 | Mechanical properties of short flax fibre bundle/polypropylene composites:Influence of matrix/fibre modification,fibre content,water uptake and recycling显示文摘 | Arbelaiz A Fernández B Ramos J A | 2005 | Composites Science and Technology2005，65，10： | 1 |
| 8 | A reliable method for Golgi staining of retina and brain slices显示文摘 | Angulo A Fernández E Merchán J A | 1996 | J Neurosci Methods1996，66，1： | 1 |
| 9 | The role of neuroimmunomodulation in Alzheimer′s disease显示文摘 | MACCIONI R B ROJO L E FERNNDEZ J A | 2009 | Ann N Y Acad Sci2009，1153，： | 1 |
| 10 | Ligninbased formulations to prevent pesticides pollution显示文摘 | Herrear F J G Fern Ndez I D Pradas E G | 2009 | J Hazard Mater2009，168，： | 1 |
| 11 | ICP-MS for absolute quantification of proteins for heteroatom-tagged, targeted proteomics显示文摘 | Alfredo Sanz-Medel María Montes-Bayón J?rg Bettmer M. Luisa Fernández-Sanchez Jorge Ruiz Encinar | 2012 | Trends in Analytical Chemistry2012，，： | 1 |
| 12 | The use of knowledge for technological innovation within diversified firms显示文摘 | Miller D J Fern M J Cardinal L B | 2007 | Academy of Management Journal2007，50，2： | 1 |
| 13 | The genesis of strategy in new ventures : escaping the constraints of founder and team knowledge 显示文摘 | FERN M J CARDINAL L B NEILL H M | 2012 | Strategic Management Journal2012，33，4： | 1 |
| 14 | Gemini surfactants from alkyl glueosides显示文摘 | Castro Mariano J L Kovensky José Cirelli Alicia Fernéndez | 1997 | Tetrahedron Letters1997，38，23： | 1 |
| 15 | An XPS study of the mixing effects induced by ion bombardment in composite oxides显示文摘 | Leinen D Fernández A Espinós J P | 1993 | Applied Surface Science1993，68，4： | 1 |
| 16 | Bayesian networks and information retrieval:An introduction to the special issue显示文摘 | Campos L M de Fernández-Luna J M Huete J F | 2004 | Information Processing and Management2004，40，5： | 1 |
| 17 | Conventional andmicrowave induced pyrolysis of coffee hulls for the production of ahydrogen rich fuel gas显示文摘 | Domínguez A Menéndez J A Fernández Y | 2007 | Journal of Analytical and Applied Pyrol-ysis2007，79，1： | 1 |
| 18 | A Network Management Approach Enabling Active and Programmable Internets显示文摘 | Millor J V Fernández J S | 2005 | IEEE Network2005，19，1： | 1 |
| 19 | The inf luence of risk factors on the severity of anti-tuberculosis drug-induced hepatotoxicity显示文摘 | Fernández-Villar A Sope a B Fernández-Villar J | 2004 | International Journal of Tuberculosis and Lung Disease2004，，12： | 1 |
| 20 | S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial显示文摘 | Mato JM Cámara J Fernández de Paz J | 1999 | J Hepatol1999，30，6： | 1 |
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