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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Chemical design of nanoparticle probes for high-performance magnetic resonance imaging显示文摘 | JUN Y W LEE J H CHEON J | 2008 | Angsw Chem Int Ed Engl2008，47，28： | 1 |
| 3 | Experiments on Vision Guided Docking of an Autonomous Underwater Vehicle Using One Camera 显示文摘 | Park J Y Jun B H | 2009 | Ocean Engineering2009，36，1： | 1 |
| 4 | Effects of rare earth elements on microstructure and high temperature mechanical properties of ZC63 alloy 显示文摘 | Jun J H Kim J M | 2005 | Journal of Materials Science2005，0，910： | 1 |
| 5 | 查看详情显示文摘 | Vishwanathan V Jun K W Kim J W Roh H S | | 0，，： | 1 |
| 6 | A new class of doubletalk detectors based on cross-correlation显示文摘 | Senesty J Dennis R M Jun H C | 2000 | IEEE Trans on Speech and Audio Processing2000，8，2： | 1 |
| 7 | Selection of microalgae for lipid production under high levels carbon dioxide 显示文摘 | YOO C JUN S Y LEE J Y AHN C Y OH H M | 2010 | Bioresoure Technology2010，101，1： | 1 |
| 8 | Hemostatic suturing technique for uterine bleeding during cesarean delivery显示文摘 | Cho J H Jun H S Lee C N | | 0，，01： | 1 |
| 9 | Evolution of Precipitates in the Nb-Ti-V Microalloyed HSLA Steels During Reheating 显示文摘 | Hong S G Jun H J Kang K B | 2003 | Seripta Materialia2003，48，： | 1 |
| 10 | Defect structure induced by iron injection in WC-Co显示文摘 | BAIK S I CHOI E G JUN J H ICIM Y W | 2008 | Scripta Materialia2008，58，： | 1 |
| 11 | Damping capacity in Fe -Mn binary alloys显示文摘 | Lee Y K Jun J H Choi C S | 1997 | ISIJ International1997，37，10： | 1 |
| 12 | Predictability of motor out- come according to the time of diffusion tensor imaging in pa- tients with cerebral infarct 显示文摘 | Yong H Yong J Jun L | 2012 | Neuroradiology2012，54，69： | 1 |
| 13 | Electrospun polyacrylonitrile nanofibers containing a high concentration of wel -aligned multiwal carbon nanotubes显示文摘 | Haoqing H Ge Jason J Jun Z | | 0，，05： | 1 |
| 14 | Experiments on vision guideddocking of an autonomous underwater vehicle using one cam-era显示文摘 | Park J Y Jun B H Lee P M | 2009 | Ocean Engineering2009，36，1： | 1 |
| 15 | Optimization of pigment production of Monascus purpureus P-57 in liquid culture显示文摘 | DUCK P C JUN J H YU T S | 2005 | Korean Society for Biotechnology and Bioengineering2005，20，1： | 1 |
| 16 | DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifalia 显示文摘 | Jun Sun N S H W And J M C | 1998 | Journal of Natural Products1998，61，3： | 1 |
| 17 | Damping capacity in Fe-Mn binary alloys显示文摘 | Lee Y K Jun J H Choi C S | 1997 | ISIJ International1997，37，10： | 1 |
| 18 | A new technique for the identification of ultrasonic flaw signals using deconvolution显示文摘 | YOUNG H K SUNG J S JUN Y K | 2004 | Ultrasonic2004，41，： | 1 |
| 19 | Synthesis of dimethyl carbonate from CH3OH and CO2 with Ce1-xZrx O2 catalysts 显示文摘 | Han G B Park N K Jun J H | 2004 | Studies in Surface Science and Catalysis2004，153，： | 1 |
| 20 | On L-fuzzy ideals in semiring I 显示文摘 | Jun Y B Chinju Neggers J Tuscaloosa Kim H S Chongju | 1998 | Czechoslovak Mathematical Journal1998，48，4： | 1 |
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