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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Comparison of ecotourism policies and implications for China's ecotourism development 显示文摘 | Wang S Heo J Yamada N Hwang S T | 2009 | Journal of China Tourism Research2009，5，3： | 1 |
| 3 | C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes 显示文摘 | Tumer N E Hwang D J | 1997 | Proc Natl Acad Sci USA1997，94，8： | 1 |
| 4 | Synthesis, characterization, and electroluminescence of new conjugated polyfluorene derivatives containing various dyes as comonomers 显示文摘 | CHO N S HWANG D H JUNG B J | 2004 | Macromolecules2004，37，14： | 1 |
| 5 | Fast and automatic video object segmentation and tracking for content-based applications 显示文摘 | KIM C HWANG J N | 2002 | IEEE Trans on Circuits Syst Video Technol2002，12，2： | 1 |
| 6 | The Cournot competition in the spatial equilibrium model显示文摘 | Yang C W Hwang M J Sohng S N | 2002 | Energy Economics2002，24，2： | 1 |
| 7 | Investigation of factors af- fecting the diffusion of mobile telephone services: An empirical analysis for Vietnam显示文摘 | Hwang J Cho Y Long N V | 2009 | Telecommunications Policy2009，33，： | 1 |
| 8 | Ground response during pile driving 显示文摘 | Hwang J H Liang N Chen C H | 2001 | Journal of Geotechnical and Geoenviron- mental Engineering2001，127，11： | 1 |
| 9 | Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid 显示文摘 | Hwang J Sevanian A Hodis H N | 2000 | Free Radical Biology & Medicine2000，29，1： | 1 |
| 10 | An analysis of factors affecting price volatility of the US oil market显示文摘 | Yang C W Hwang M J Huang B N | 2002 | Energy Economics2002，24，2： | 1 |
| 11 | Rotational Response and Slip Prediction of Serpentine Belt Drive Systems 显示文摘 | Hwang S J Perkins N C Ulsoy A G | 1994 | ASME Journal of Vibration and Acoustics1994，116，1： | 1 |
| 12 | Clinical experi- ence with intra-aortic balloon counterpulsation over 10 years:A retrospective cohort study of 459 patients 显示文摘 | Chang S N Hwang J J Chen Y S | 2008 | Resuscitation2008，77，3： | 1 |
| 13 | A neural network--based stochastic active contour model (NNS-Snake) for contour finding of distinct feature显示文摘 | Hwang J N | 1995 | IEEE Tran Image Processing1995，，10： | 1 |
| 14 | Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract 显示文摘 | HWANG J HODIS H N SEVANIAN A | 2001 | J Agric Food Chem2001，49，1： | 1 |
| 15 | Lid margin split in the surgical correction of epiblepharon 显示文摘 | Hwang SW Khwarg SI Kim N J | 2008 | Acta Opthal- mol2008，86，： | 1 |
| 16 | Response of zonal chondrocytes to extracellular matrix-hydrogels 显示文摘 | Hwang N S Varghese S Lee H J | 2007 | FEBS Letters2007，581，22： | 1 |
| 17 | Prediction of interface reaction products between Cu and various solder alloys by thermodynamic calculation 显示文摘 | Lee B J Hwang N M Lee H M | 1997 | Acta Mater1997，45，5： | 1 |
| 18 | Object-based analysis and interpretation of human motion in sports video sequences by dynamic Bayesian networks显示文摘 | Luo Y Wu T D Hwang J N | 2003 | CVIU2003，92，2： | 1 |
| 19 | Achieving biofilm control in a membrane biofilm reactor removing total nitrogen显示文摘 | Hwang J H Cicek N | 2010 | Water Research2010，44，7： | 1 |
| 20 | Evaluation of a Turkish low quality oil shale by flotation as a clean energy source:Material characterization and determination of flotation behavior显示文摘 | Altun E N Hicyilmaz C Hwang J Y | | 0，，： | 1 |
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