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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/pheno- type to thriftiness显示文摘 | Fernandez Real J M Ricart W | 1999 | Diabetologia1999，42，11： | 1 |
| 3 | Effects of increasing dietary niacin on growth perform- ance and meat quality in finishing pigs reared in two different environments 显示文摘 | REAL D E NELSSEN J L UNRUH J A | 2002 | Journal of Animal Sci- ence2002，80，12： | 1 |
| 4 | Classification of landscapes using quantitative and categorical data, and prediction of their scenic beauty in North-Western Spain显示文摘 | Real E Arce C Sabucedo J | 2000 | Journal of Environmental Psychology2000，20，： | 1 |
| 5 | Degradation of Carbofuran by Using Ozone,UV Radiation and Advanced Oxidation Processes显示文摘 | BENITEZ F J ACERO J L REAL F J | 2002 | Journal of Hazardous Materials2002，89，： | 1 |
| 6 | Pullback attractors for asymptotically compact non-autonomous dynamical systems 显示文摘 | Caraballo T Lukaszewicz G Real J | 2006 | Nonlinear Analysis2006，64，3： | 1 |
| 7 | Removal of phenyl-urea herbicides in ultrapure water by ultrafiltration and nanofiltration processes显示文摘 | Benitez F J Acero J L Real F J | 2009 | Water Research2009，43，2： | 1 |
| 8 | Ricart, Insulin resistance and chronic cardiovascular inflammatory syndrome显示文摘 | Fernandez Real J M W | 2003 | Endo- crine Reviews2003，24，3： | 1 |
| 9 | Attractors for 2D-Navier-Stokes models with delays显示文摘 | Caraballo T Real J | 2004 | J Differential Equations2004，205，： | 1 |
| 10 | Pullback attractors in V for non-autonomous 2D-Navier-Stokes equations and their tempered behaviour 显示文摘 | Garca-Luengo J Marn-Rubio P Real J | 2012 | Journal of Differential Equations2012，252，8： | 1 |
| 11 | Electrochemical impedance spectroscopy study of zinc rich paints on steels in artificial sea water by a transmission line model 显示文摘 | Real S G Elias A C Vilche J R | 1993 | Electrochimica Acta1993，38，14： | 1 |
| 12 | Treatment of he- patocellular carcinoma显示文摘 | Forner A Hessheimer A J Isabel Real M | 2006 | Crit Rev Oncol Hematol2006，60，2： | 1 |
| 13 | On the relation between two different concepts of pullback attractors for non-autonomous dynamical systems 显示文摘 | Marn-Rubio P Real J | 2009 | Nonlinear Analysis2009，71，9： | 1 |
| 14 | Pullback attractors for asymptotically compact Non- autonomous dynamical Systems显示文摘 | Caraballo T Lukaszewicz G and Real J | 2006 | Nonlinear Analysis2006，，64： | 1 |
| 15 | Classification of landscapes using quantitative and categorical data, and prediction of their scenic beauty in North-western Spain显示文摘 | Real E Arce C Sabucedo J M | 2000 | Journal of Environmental Psychology2000，20，： | 1 |
| 16 | Preparation of silica from rice husks 显示文摘 | Real C Alcald M D Criado J M | 1996 | J Am Ceram Soc1996，79，8： | 1 |
| 17 | Pullback attractor for asymptotically compact nonautonomoas dynamical systems显示文摘 | Caraballo T Lukaszewiez G Real J | 2006 | Nolinear Anal2006，64，： | 1 |
| 18 | Nitrogen losses during the composting of sewage sludge显示文摘 | Witter E Lopez Real J | 1988 | Biol Wast1988，23，： | 1 |
| 19 | Oxidation of MCPA and 2,4-D by UV radiation,ozone,and the combinations UV/H O and O/H O显示文摘 | Benitez F J Acero J L Real F J | 2004 | Journal of 2 2 3 2 2Environmental Science and Health Part B2004，39，3： | 1 |
| 20 | Attractors for 2D-Navier-Stokers models with delays 显示文摘 | CARABALLO T REAL J | 2004 | J Diff Eqs2004，205，2： | 1 |
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