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| 1 | Changes in lipid metabolism in chronic hepatitis C显示文摘AIM: To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver.METHODS: The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C (CH-C), and 28 patients with non-alcoholic fatty liver disease (NAFLD) without hepatitis C virus (HCV) infection. The serum parameters were further correlated with 1 797 age and sex matched control patients without any liver diseases.RESULTS: Steatosis was detected in 90 out of 142 specimens (63%) with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD (P<0.01). Inserting the score values of steatosis as part of the HAI, correlation with the ALT level (P<0.00001) was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C (with and without steatosis), compared to the NAFLD group and to the virus-free control groups.CONCLUSION: Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation. | Katalin Jármay Gizella Karácsony András Nagy Zsuzsa Schaff | 2005 | World Journal of Gastroenterology2005，11，41： | 22 |
| 2 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Cox-maze Procedure for Atrial Fibrillation:Mayo Clinic Experience显示文摘 | Schaff H V Dearani J A Daly R C | 2000 | Semin Thorac Cardiovasc Surg2000，12，1： | 1 |
| 4 | Life prediction methodology for composite structures, Part Ⅰ-constant amplitude and two-stress level fatigue显示文摘 | SCHAFF J R DAVIDSON B D | 1997 | Journal of Composite Materials1997，31，： | 1 |
| 5 | Acute aortic dissection: population based incidence compared with degenerative aortic aneurysm rupture显示文摘 | Clouse W D Hallett J W Jr Schaff H V | 2004 | Mayo Clin Proc2004，79，2： | 1 |
| 6 | Temperature dependence of performance of In-GaN/GaN MQW LEDs with different indium compo-sitions显示文摘 | Huh Chul Schaff William J Eastman Lester F | 2004 | IEEE Electron Device Letters2004，25，2： | 1 |
| 7 | Life Prediction Methodology for Composite Structures: Part I- constant Amplitude and Two-stress Level Fatigue 显示文摘 | Schaff J R Davidson B D | 1997 | Journal of Composite Materials1997，31，2： | 1 |
| 8 | A Multistage representation of the wiener filter based on orthogonal projection 显示文摘 | Goldstein J S Reed I S Schaff L L | 1998 | IEEE Transactions on Information Theory1998，44，7： | 1 |
| 9 | Object level grouping for video shots 显示文摘 | Sivic J Schaff'alitzky F Zisserman A | 2006 | International Journal of Computer Vision(S0920-5691)2006，67，2： | 1 |
| 10 | Multiple arterial grafts improve late survival of patients undergoing coronary artery bypass graft surgery:analysis of 8622 pa- tients with multivessel disease 显示文摘 | LOCKER C SCHAFF H V DEARANI J A | 2012 | Circulation2012，126，9： | 1 |
| 11 | Influence of cut- ting edge radius on the wear resistance of PM-HSS milling inserts显示文摘 | RECH J YEN Y-C SCHAFF MJ | 2005 | Wear2005，259，7： | 1 |
| 12 | Cytokinins play opposite roles in lateral root formation, and nematode and rhizobial symbioses 显示文摘 | Lohar D P Schaff J E Laskey J G | 2004 | The Plant Journal : for Cell and Molecular Biology2004，38，2： | 1 |
| 13 | Calibrating corn color from aerial photegraphs to predict side dress N need显示文摘 | Lory J A | 2002 | Agronomy Journal2002，94，： | 1 |
| 14 | Influence of preoperative atrial fibrillation on late results of mitral repair: is concomitant ablation justified-显示文摘 | Ngaage D L Schaff H V Mullany C J Barnes S Dearani J A Daly R C | 2007 | Ann Thorac Surg2007，84，： | 1 |
| 15 | Acute aortic dissection:population-based incidence compared with degenerative aortic aneurysm rupture显示文摘 | Clouse W D Hallett J W Schaff H V | 2004 | Mayo Clin Proc2004，79，2： | 1 |
| 16 | Risk of thromboembolism with the aortic Carpentier-Edwards bioprosthesis显示文摘 | Orszulak TA Schaff HV Mullany C J | 1995 | Ann Thorac Surg1995，59，： | 1 |
| 17 | Prognostic implications of preoperative atrial fibrillation in patients undergoing aortic valve replacement: is there an argument for concomitant arrhythmia surgery-显示文摘 | Ngaage D L Schaff H V Barnes S A Sundt T M 3rd Mullany C J Dearani J A | 2006 | Ann Thorac Surg2006，82，： | 1 |
| 18 | A photoelectron diffraction study of ordered structures in the chemisorption system Pd{111}-CO显示文摘 | Gieael T Schaff O Hirschmugl C J | 1998 | Surf Sci1998，406，13： | 1 |
| 19 | Life prediction methodology for composite structures: part I-constant amplitude and two-stress level fatigue显示文摘 | Schaff J R Dacidson B D | 1997 | Journal of Composite Materials1997，31，2： | 1 |
| 20 | Surface charge accumulation of ln N films grown by molecular-beam epitaxy显示文摘 | LU H SCHAFF W J EASTMAN L F | 2003 | Applied Physics Letters2003，82，11： | 1 |
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