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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | Paleoenvironmental records from the northern South China Sea since the Last Glacial Maximum显示文摘Core ZHS-176 contains the paleoenvironmental records from the northern South China Sea (NSCS) since the Last Glacial Maximum (LGM). A coupled approach based on clay mineral assemblages, planktonic foraminiferal oxygen and carbon isotopes, and calcium carbonate content is used to trace the sources of the fine-grained sediment and to investigate the paleoenviornmental evolution in this area. Clay mineral assemblages are dominated by illite (average about 39%) and chlorite (about 27%), which comes mainly from Taiwan and the East China Sea. Kaolinite, which accounts for about 13%, comes mainly from the Zhujiang (Pearl) River, and Luzon Island is the main source for smectite (about 21%). The planktonic foraminiferal oxygen isotopic oscillations during the last glacial period are coeval with climate variations recorded in the Greenland ice core and Western Pacific sediment. These variations include the LGM, Heinrich event 1, Bφlling-Allerφd (B/A), and Younger Dryas. For the Holocene, three periods of strong precipitation (S1-S3) and three periods of weak precipitation (W1-W3) are identified. The oxygen isotopic record exhibits corre-lation with climate records from distant regions, including the high-latitude Northern Hemisphere, providing evidence for global tele-connection among regional climate. A brief, negative planktonic foraminiferal carbon isotopic excursion during B/A reflects increased methane released from marine gas hydrate due to the rapid warming of the water. By comparing calcium carbonate content curves of the core ZHS-176 with these of other five boreholes lying above the lysocline, a remarkable low calcium carbonate event is found during the early Holocene in NSCS. | GE Qian CHU Fengyou XUE Zuo LIU J Paul DU Yuansheng FANG Yinxia | 2010 | Acta Oceanologica Sinica2010，29，3： | 13 |
| 3 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 4 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 5 | Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene $18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population显示文摘 | Xue S Jia J | 2006 | 中国生物学文摘2006，20，8： | 5 |
| 6 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 7 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 8 | Structural insights into Ca^2+-activated long-range allosteric channel gating of RyR1显示文摘Ryanodine 受体(RyRs ) 是有分子的质量的巨大的离子隧道的一个班超过 2.2 大 -- 道尔顿。这些隧道调停钙在许多房间发信号。因为超过 80% RyR 蛋白质被合拢进细胞质的集会,留下的残余形成 transmembrane 领域, RyR 隧道的激活和规定发生通过,这被假设了一迄今为止 uncharacterized 远程的 allosteric 机制。这里,我们报导 Ca 2+-activated 的描述由 cryo 电子的开状态的 RyR1 结构显微镜学。结构有 4.9 Å 的一个全面决定;并且 4.2 Å 的一个决定;为核心区域。与以前坚定的 apo/closed-state 结构比较,我们在 Ca 2+ 激活之上观察了隧道的远程的 allosteric gating。深入的结构的分析阐明了新奇隧道门机制和 RyR1 的新奇离子选择机制。我们的工作不仅提供结构的卓见进隧道 gating 和 RyRs 的规定的分子的机制,而且为 six-transmembrane-helix 阳离子隧道家庭为隧道门和离子选择机制使结构的基础清楚些。 | Risheng Wei Xue Wang Yan Zhang Saptarshi Mukherjee Lei Zhang Qiang Chen Xinrui Huang Shan Jing Congcong Liu Shuang Li Guangyu Wang Yaofang Xu Sujie Zhu Alan J Williams Fei Sun Chang-Cheng Yin | 2016 | Cell Research2016，26，9： | 3 |
| 9 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 10 | Recent highlights of the China rice functional genomics program显示文摘 | XUE Y LI J XU Z | 2003 | TRENDS in Genetics2003，19，： | 2 |
| 11 | The fabrication of color-tunable organic light-emitting diode displays via solution processing显示文摘Electroluminescent devices based on organic semiconductors have attracted significant attention owing to their promising applications in flat-panel displays.The conventional display pixel consisting of side-by-side arrayed red,green and blue subpixels represents the mature technology but bears an intrinsic deficiency of a low pixel density.Constructing an individual color-tunable pixel that comprises vertically stacked subpixels is considered an advanced technology.Although color-tunable organic light-emitting diodes(OLEDs)have been fabricated using the vacuum deposition of small molecules,the solution processing of conjugated polymers would enable a much simpler and inexpensive manufacturing process.Here we present the all-solution processing of color-tunable OLEDs comprising two vertically stacked polymer emitters.A thin layer of highly conducting and transparent silver nanowires is introduced as the intermediate charge injection contact,which allows the emission spectrum and intensity of the tandem devices to be seamlessly manipulated.To demonstrate a viable application of this technology,a 4-by-4 pixelated matrix color-tunable display was fabricated. | Fei Guo Andre Karl Qi-Fan Xue Kai Cheong Tam Karen Forberich Christoph J Brabec | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 12 | Chatter identification of thin-walled parts for intelligent manufacturing based on multi-signal processing显示文摘Machine chatter is still an unresolved and challenging issue in the milling process,and developing an online chatter identification and process monitoring system towards smart manufacturing is an urgent requirement.In this paper,two indicators of chatter detection are investigated.One is the real-time variance of milling force signals in the time domain,and the other one is the wavelet energy ratio of acceleration signals based on wavelet packet decomposition in the frequency domain.Then,a novel classification concept for vibration condition,called slight chatter,is proposed and integrated successfully into the designed multi-classification support vector machine(SVM)model.Finally,a mapping model between image and chatter indicators is established via a distance threshold on the image.The multi-SVM model is trained by the results of three signals as an input.Experiment data and detection accuracy of the SVM model are verified in actual machining.The identification accuracy of 96.66%has proved that the proposed solution is feasible and effective.The presented method can be used to select optimized milling parameters to improve machining process stability and strengthen manufacturing system monitoring. | Dong-Dong Li Wei-Min Zhang Yuan-Shi Li Feng Xue Jürgen Fleischer | 2021 | Advances in Manufacturing2021，9，1： | 2 |
| 13 | Tribological behavior of microarc oxidation coatings on aluminum alloy显示文摘 | Xue W Du J Wu X | 2006 | ISIJ Int2006，46，： | 1 |
| 14 | 显示文摘 | Sohlberg K Xue Z Q | 2000 | Phys Rev Lett2000，84，： | 1 |
| 15 | Aspirin inhibits MPP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes显示文摘 | Hua Y Xue J Sun F | 2009 | Pharmacology2009，83，1： | 1 |
| 16 | Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: a comparative in vivo study 显示文摘 | Xiao SH Xue J Tanner M | 2008 | Acta Trop2008，106，1： | 1 |
| 17 | Dissolved organic matter (DOM) in recycled leachate of bioreactor landfill 显示文摘 | He P J Xue J F Shao L M | 2006 | Water Res2006，40，7： | 1 |
| 18 | Microstructure and tribological behaviour of nitrocarburizing-quenching duplex treated steel 显示文摘 | Qiang Y H Ge S R Xue Q J | 1999 | Tribology International1999，32，3： | 1 |
| 19 | An androgen-regulated miRNA suppresses Bakl expression and induces androgen-independent growth of prostate cancer cells显示文摘 | Shi XB Xue L Yang J | 2007 | Proc Nat Acad Sci U S A2007，104，19： | 1 |
| 20 | A comparative study of impulse-resistant metal sandwich plates 显示文摘 | Xue Z Y Hutchinson J W | 2004 | International Journal of Impact Engineering2004，，30： | 1 |
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