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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | 中年成人平均动脉压的体位改变与动脉硬度的关系:Framingham心脏研究显示文摘Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults:the Framingham heart study. Hyperten- sion,2017,69(4) :685-690.站立位血压稳定调节受损可导致不良结果,包括跌倒、晕厥和定向障碍。平均动脉压(meanarterialpressure,MAP)通常在站立位时增加,然而,站立位MAP增加不足或减少可能导致脑灌注减少。已有研究报道,在动脉硬度增加的老年人中存在体位性低血压,年轻至中年人MAP的体位性改变与动脉硬度的相关性尚未阐明。该研究分析了Framingham心脏研究第3代队列中的受试者3205人(女性1693人,占53%)的直立性血压反应和全面血液动力学数据。 | Torjesen A Cooper LL Rong J Larson MG Hamburg NM Levy D Benjamin EJ Vasan RS Mitchell GF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，3： | 5 |
| 4 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 5 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 6 | Time Temperature Relation for Rupture and Creep Stresses显示文摘 | Larson F R Miller J A | 1952 | Trans ASME1952，74，： | 1 |
| 7 | Clonal origin of recurrent meningiomas显示文摘 | von Deimling A Larson J Wellenreuther R | 1999 | Brain Pathol1999，9，4： | 1 |
| 8 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 9 | Federated database system for managing distributed, heterogeneous, and autonomous database 显示文摘 | SHETH A P LARSON J A | 1990 | AGM Computing Suweys1990，22，3： | 1 |
| 10 | Reimmunization after allogeneic bone marrow transplan taton显示文摘 | Somani J Larson R A | | 0，，： | 1 |
| 11 | Rebound of five one-dimensionally compressed unsaturated granular soils显示文摘 | STONE J A LARSON W E | 1980 | Soil Science Society of America Journal1980，44，4： | 1 |
| 12 | Disruption Management 显示文摘 | Clausen J Hansen J LsrBon J Larson A | 2001 | OR/MS Today2001，28，5： | 1 |
| 13 | Inactivation of Bacillus subtilis spores with ozone and monochloramine显示文摘 | Larson M A Marinas B J | 2003 | Water Research2003，37，4： | 1 |
| 14 | Reli- ability and validity of the 12 - minute distance walk in pa- tients with chronic obstructive pulmonary disease显示文摘 | LARSON J L COVEY M K VITALO C A | 1996 | Nurs Res1996，45，4： | 1 |
| 15 | A conserved domain in the coronavirus membrane protein tail is important for virus assembly 显示文摘 | Arudt A L Larson B J Hogue B G | 2010 | J Virol2010，84，11： | 1 |
| 16 | Adult stem eells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential 显示文摘 | PEISTER A MELLAD J A LARSON B L | 2004 | Blood2004，103，5： | 1 |
| 17 | Individual and combined effects of peroxisome proliferator-activated receptor and {gamma}agonists,fenofibrate and rosiglitazone,on biomarkers of lipid and glucose metabolism in healthy nondiabetie volunteers显示文摘 | Wagner J A Larson P J Weiss S | 2005 | J Clin Pharmacol2005，45，5： | 1 |
| 18 | A network model of organization formation显示文摘 | Larson A Starr J A | 1993 | Entrepreneurship: Theory and Practice1993，17，2： | 1 |
| 19 | Federated database systems for managing distributed, heterogeneous, and autonomous databases显示文摘 | Sheth A P Larson J A | 1990 | ACM Computing Surveys1990，22，3： | 1 |
| 20 | Traumatic intracranial aneurysms显示文摘 | Larson P S Reisner A Morassutti D J | | 0，，01： | 1 |
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