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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Total knee arthoplasty in pateents with a prior fracture of lhe tibial plateau显示文摘 | Nicholsa G Weiss M Javad F | 2003 | J Bone Joint Surg(Am)2003，85，5： | 1 |
| 3 | Total knee arthoplasty in patients with a prior fracture of the tibial plateau显示文摘 | Nicholas G Weiss M Javad F | 2003 | J Bone Joint Surg Am2003，85，5： | 1 |
| 4 | An intelligent neural system for predicting structural response subject to earthquakes 显示文摘 | Saeed G Javad S Eysa S | 2009 | Advances in Engineering Software2009，40，8： | 1 |
| 5 | Novel modi-fled UWB planar monopoleantenna with variable frequency band-notch function显示文摘 | REZA Z CHANGIZ G JAVAD N | 2008 | IEEE Antennasand Wireless Propagation Letters2008，9，7： | 1 |
| 6 | Preferred feed direction field: A new tool path generation method for efficient sculptured surface machi- ning 显示文摘 | H Kumazawa G Feng HY M Javad BF | 2015 | Computer - Aided Design2015，6768，： | 1 |
| 7 | A simple and unified meth- od to model HVDC links and facts devices in DC load flow显示文摘 | Mousavi Omid Alizadeh Sanjari Mohammad Javad Gharehpetian G B | 2009 | Simulation2009，85，2： | 1 |
| 8 | Ultrasonic assisted grinding of Ti6A14V alloy 显示文摘 | MOHSEN G N MOHAMMAD R M JAVAD A | 2012 | Annals of the CIRP2012，1，： | 1 |
| 9 | Total knee arthoplasty in patients with a prior fracture of the tibial plateau显示文摘 | Nicholas G Weiss M Javad F | 2003 | J Bone Joint Surg (Am)2003，85，5： | 1 |
| 10 | Determination of Nonlinear Behavior of A Ball Joint System by Model Updating 显示文摘 | Mohammad R D Javad V A Sirous G | 2012 | Journal of Constructional Steel Research2012，71，： | 1 |
| 11 | Bandwidth enhancementof novel compact single and dual band - notched printedmonopole antenna with a pair of L - shaped slots 显示文摘 | REZA Z CHANGE G JAVAD N | 2009 | IEEETrans Antennas Propag2009，57，3： | 1 |
| 12 | Tatol knee arthoplasty in patients with a prior fracture of the tibial plateau 显示文摘 | Nicholas G Weiss M Javad F | 2003 | J Bone Joint Sury Am2003，85，5： | 1 |
| 13 | Modeling injection of dense liquid sprays in radio frequency inductively coupled plasmas显示文摘 | Shan Y G Javad M | 2005 | Plasma Chemistry and Plasma Processing2005，25，3： | 1 |
| 14 | A production rate control policy for stochastic repair and remanufacturing systems显示文摘 | Robert P Javad S Ali G | 2009 | International Journal of Production Economics2009，121，2： | 1 |
| 15 | Total knee arthroplasty in pa-tients with a prior fracture of the tibial plateau 显示文摘 | Nicholas G Weiss M Javad F | 2003 | J Bone Joint Surg Am2003，85，5： | 1 |
| 16 | Mechanical properties of NBR/clay nanocomposites by using a novel testing system显示文摘 | Seyed Javad Ahmadi Christian G'Sell Yudong Huang | 2009 | Composites Science and Technology2009，，： | 1 |
| 17 | Mechanical properties of NBR/clay nanocomposites by using a novel testing system显示文摘 | Seyed Javad Ahmadi Christian G'Sell Yudong Huang etal | 2009 | Composites Science and Technology2009，，： | 1 |
| 18 | Root to shoot communication and abscisic acid in calreticulin (CR) gene expression and salt-stresstolerance in grafted diploid potato clones显示文摘 | JAVAD S FAWZY G ATT A H | 2005 | Environmental and Experimental Botany2005，53，3： | 1 |
| 19 | Discrete wavelet decomposition of acoustic emission signals from carbon-fiber-reinforced composites 显示文摘 | QI G ALAN B JAVAD H | 1997 | Composites Science and Technology1997，57，： | 1 |
| 20 | Total knee arthoplasty in patients with a prior fracture of the tibial plateau 显示文摘 | Weiss M Javad F | 2003 | J Bone Joint Surg Am2003，85，5： | 1 |
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