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| 1 | Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，7： | 33 |
| 2 | Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction:A review of clinical evidence and guidelines显示文摘Acute ST segment elevation myocardial infarction(STEMI) is characterized by complete thrombotic occlusion of a major coronary artery. Early recanalization of the infarct-related artery is most efficiently delivered by primary percutaneous coronary intervention(PPCI),however this does not always restore normal myocardial perfusion,mainly due to distal embolization of the thrombus and microvascular obstruction. Early evidence for manual thrombus aspiration during PPCI was promising and this was once considered an important aspect of the procedure,especially in patients with a high thrombus burden. However,a large body of evidence from recent major randomized controlled trials(notably TASTE and TOTAL) does not support the routine use of manual thrombus aspiration in patients with STEMI undergoing PPCI. | Muhammad Muzaffar Mahmood Jonathan Watt Javed M Ahmed | 2015 | World Journal of Cardiology2015，7，12： | 7 |
| 3 | Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis显示文摘AIM: To undertake a meta-analysis on the value of urinary trypsinogen activation peptide (uTAP) in predicting severity of acute pancreatitis on admission. METHODS: Major databases including Medline, Embase, Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched to identify all relevant studies from January 1990 to January 2013. Pooled sensitivity, specificity and the diagnostic odds ratios (DORs) with 95%CI were calculated for each study and were compared to other systems/biomarkers if mentioned within the same study. Summary receiver-operating curves were conducted and the area under the curve (AUC) was evaluated. RESULTS: In total, six studies of uTAP with a cut-off value of 35 nmol/L were included in this meta-analysis. Overall, the pooled sensitivity and specificity of uTAP for predicting severity of acute pancreatitis, at time of admission, was 71% and 75%, respectively (AUC = 0.83, DOR = 8.67, 95%CI: 3.70-20.33). When uTAP was compared with plasma C-reactive protein, the pooled sensitivity, specificity, AUC and DOR were 0.64 vs 0.67, 0.77 vs 0.75, 0.82 vs 0.79 and 6.27 vs 6.32, respectively. Similarly, the pooled sensitivity, specificity, AUC and DOR of uTAPvs Acute Physiology and Chronic Health Evaluation Ⅱ within the first 48 h of admission were found to be 0.64 vs 0.69, 0.77 vs 0.61, 0.82 vs 0.73 and 6.27vs 4.61, respectively. CONCLUSION: uTAP has the potential to act as a stratification marker on admission for differentiating disease severity of acute pancreatitis. | Wei Huang Kiran Altaf Tao Jin Jun-Jie Xiong Li Wen Muhammad A Javed Marianne Johnstone Ping Xue Christopher M Halloran Qing Xia | 2013 | World Journal of Gastroenterology2013，19，28： | 7 |
| 4 | Hepatocytes isolated from neoplastic liver-immunomagnetic purging as a new source for transplantation显示文摘AIM: To investigate whether hepatocytes isolated from macroscopically normal liver during hepatic resection for neoplasia could provide a novel source of healthy hepatocytes, including the development of reliable protocols for malignant cells removal from the hepatocyte preparation. METHODS: Hepatocytes were procured from resected liver of 18 patients with liver tumors using optimised digestion and cell-enrichment protocols. Suspensions of various known quantities of the HT-29 tumor cell line and patient hepatocytes were treated or not with Ep-CAM-antibody-coated immunomagnetic beads in order to investigate the effi cacy of tumor-purging by immunomagnetic depletion, using a semi-quantitative RT-PCR method developed to detect tumor cells. Immunomagnetic bead-treated or bead-untreated tumor cell-hepatocyte suspensions were transplanted intra-peritoneally in Balb/C nude mice to assess the rates of tumor development. RESULTS: Mean viable hepatocyte yield was 9.3 x 106 cells per gram of digested liver with mean viability of 70.5%. Immunomagnetic depletion removed tumor cells to below the RT-PCR detection-threshold of 1 tumor cell in 106 hepatocytes, representing a maximum tumor purging efficacy of greater than 400 000-fold. Transplanted, immunomagnetic bead-purged tumor cell-hepatocyte suspensions did not form peritonealtumors in Balb/C nude mice. Co-transplantation of hepatocytes with tumor cells did not increase tumorigenesis of the tumor cells. CONCLUSION: Immunomagnetic depletion appears to be an effective method of purging contaminating tumor cells to below threshold for likely tumorigenesis. Along with improved techniques for isolation of large numbers of viable hepatocytes, normal liver resected for neoplasia has potential as another clinically useful source of hepatocytes | Aravin Gunasegaram Javed Akhter Peng Yao Loreena A Johnson Stephen M Riodan David L Morris | 2008 | World Journal of Gastroenterology2008，14，32： | 2 |
| 5 | Analytic solution for MHD rotating flow of a second grade fluid over a shrinking surface显示文摘 | Hayat T Javed T Sajid M | 2008 | Phy Lett A2008，372，18： | 1 |
| 6 | Control of com bustion-generated nitrogen oxides by selective non-cata- lytic reduction 显示文摘 | JAVED M T IRFAN N GIBBS B M | 2007 | Journal of Environmental Management2007，83，3： | 1 |
| 7 | Feature selection based on class-dependent densities for high-dimensional bi-nary data显示文摘 | JAVED K BABRI H A SAEED M | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，3： | 1 |
| 8 | Studies on organic foulants in the seawater feed of reverse osmosis plants of SWCC 显示文摘 | Dalvi A G I AI-Rasheed R Javeed M A | 2000 | Desalination2000，35，13： | 1 |
| 9 | Expression and regu lation of Runx2/ Cbfa1and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts 显示文摘 | Prince M Banerjee C Javed A | 2001 | J Cell Biochem2001，80，3： | 1 |
| 10 | Object tracking:A survey显示文摘 | Yilmaz A Javed O Shah M | 2006 | Acre Computing Surveys (CSUR)2006，38，4： | 1 |
| 11 | Object Tracking: A Survey显示文摘 | A Yilmaz O Javed and M Shah | 2006 | ACM Computing Surveys2006，38，4： | 1 |
| 12 | Object Tracking: A Survey显示文摘 | Yilmaz A Javed O Shah M | 2006 | ACM Computing Surveys2006，38，4： | 1 |
| 13 | Experimental and modeling study of the effect of CO and H2 on the urea DeNOx process in a 150kW laboratory reactor显示文摘 | Javed M T Nirnmo W Gibbs B M | 2008 | Chemosphere2008，70，6： | 1 |
| 14 | Control of combustion-generated nitrogen oxides by selective non-catalytic reduction显示文摘 | Javed M T Irfan N Gibbs B M | 2007 | Journal of Environmental Management2007，83，3： | 1 |
| 15 | Control of combustion generated nitrogen oxides by selective non-cata- lytic reduction 显示文摘 | JAVED M T IRFAN N GIBBS B M | 2007 | Journal of Environmental Management2007，83，3： | 1 |
| 16 | Object tracking:a sur-vey显示文摘 | Yilmaz A Javed O Shah M | 2006 | ACM Computing Surveys(CSUR)2006，38，4： | 1 |
| 17 | Object tracking: a survey 显示文摘 | Yilmaz A Javed 0 Shah M | 2006 | AcmComputing Surveys2006，38，1： | 1 |
| 18 | Control of combustion-generated nitrogen oxides by selective non-catalytic reduction显示文摘 | Javed M T Irfan N Gibbs B M | 2007 | Journal of Environmental Management2007，83，3： | 1 |
| 19 | Object tracking: a survey 显示文摘 | YILMAZ A JAVED O SHAH M | 2006 | ACM Computing Surveys2006，38，4： | 1 |
| 20 | Rutin prevents cog- nitiv impairments by ameliorating oxidative stress and neu- roinflammation in rat model of sporadic dementia of Alzheimer typd显示文摘 | JAVED H KHAN M M AHMAD A | 2012 | Journal of Neuroscienee2012，210，： | 1 |
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