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| 1 | A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication显示文摘Helicobacter pylori(H. pylori) affects nearly half of the world's population and, thus, is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with peptic ulcer disease, gastric ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Various diagnostic methods exist to detect infection, and the choice of one method or another depends on several factors, such as accessibility, advantages and disadvantages of each method, cost, and the age of patients. Once H. pylori infection is diagnosed, the clinician decides whether treatment is necessity, according to the patient's clinical condition. Typically, eradication of H. pylori is recommended for treatment and prevention of the infection. Cure rates with the standard triple therapy are acceptable, and effective quadruple therapies, sequential therapies, and concomitant therapies have been introduced as key alternatives to treat H. pylori infection. In this work, we review the main diagnostic methods used to identify H. pylori infection and to confirm eradication of infection. In addition, key factors related to treatment are reviewed. | Elvira Garza-González Guillermo Ignacio Perez-Perez Héctor Jesús Maldonado-Garza Francisco Javier Bosques-Padilla | 2014 | World Journal of Gastroenterology2014，20，6： | 17 |
| 2 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 3 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 4 | The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle显示文摘Carbamoyl phosphate synthetase 1(CPS1) deficiency(CPS1D) is an inborn error of the urea cycle having autosomal(2q34) recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of missense mutations reported in patients with CPS1 deficiency that map in the 20-k Da C-terminal domain of the enzyme. This domain turns on or off the enzyme depending on whether the essential allosteric activator of CPS1, N-acetylL-glutamate(NAG), is bound or is not bound to it. To carry out the present studies, we exploited a novel system that allows the expression in vitro and the purification of human CPS1, thus permitting site-directed mutagenesis. These studies have clarified disease causation by individual mutations, identifying functionally important residues, and revealing that a number of mutations decrease the affinity of the enzyme for NAG. Patients with NAG affinity-decreasing mutations might benefit from NAG site saturation therapy with N-carbamyl-Lglutamate(a registered drug, the analog of NAG). Our results, together with additional present and prior site-directed mutagenesis data for other residues mapping in this domain, suggest an NAG-triggered conformational change in the b4-a4 loop of the C-terminal domain of this enzyme. This change might be an early event in the NAG activation process. Molecular dynamics simulations that were restrained according to the observed effects of the mutations are consistent with this hypothesis, providing further backing for this structurally plausible signaling mechanism by which NAG could trigger urea cycle activation via CPS1. | Carmen Díez-Fernández José Gallego Johannes H?berle Javier Cervera Vicente Rubio | 2015 | Journal of Genetics and Genomics2015，42，5： | 7 |
| 5 | Long-term evaluation of biliary reconstruction after partial resection of segments IV and V in iatrogenic injuries显示文摘 | Miguel ángel Mercado M.D. Carlos Chan M.D. Héctor Orozco M.D. José M. Villalta M.D. Alexandra Barajas-Olivas M.D. Javier Era?a M.D. Ismael Domínguez M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 3 |
| 6 | Smoking is not associated with nonalcoholic fatty liver disease显示文摘瞄准:分析在吸烟和不含酒精的脂肝疾病(NAFLD ) 之间的关系。方法:这是一张健康人口的代表性的研究,在墨西哥在一所大学医院的一个检查单位执行了城市。我们注册了 933 个题目, 368 个当前的吸烟者(盒子) 和从来没吸过的 565 个人(控制) 。人口统计、新陈代谢、生物化学的变量在二个组被测量。NAFLD 被超声和新陈代谢的症候群根据 ATPIII 决定。结果:548 个男人(205 个盒子和 343 控制) 和 337 个女人(114 个盒子和 223 控制) 的一个总数在分析被包括。盒子和控制之间的统计差别仅仅在高血压流行被观察(6.6% 对 11.3% , P <
0.05;盒子和控制分别地),高密度的脂蛋白( 1.00 +/- 0.26 对 1.06 +/- 0.28 mmol/L , P <
0.005 ), triglycerides ( 2.18 +/- 1.49 对 1.84 +/- 1.1 mmol/L , P <
0.001 ),并且红细胞沉降率( 11.3 +/- 9.3 对 13.5 +/- 11.9 mm/h , P <
0.001 )。没有差别在 NAFLD 的流行被观察(22.27% 对 29.68% , P = NS ) 并且新陈代谢的症候群(41.69% 对 36.74% , P = NS ) 。Univariate 分析证明吸烟不是为 NAFLD 的一个风险因素(或 = 0.89, 95% CI 0.65-1.21 ) 。结论:在 NAFLD 流行的差别都没在当前的吸烟者和不抽烟的人之间被观察,并且而且,没有差别在重吸烟者(超过 20 包装 / 年) 被观察,显示在吸烟和 NAFLD 之间没有关系。 | Norberto C Chavez-Tapia Javier Lizardi-Cervera Oliver Perez-Bautista Martha H Ramos-Ostos Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，32： | 2 |
| 7 | Plants against the global epidemic of arsenic poisoning显示文摘 | Itziar A Javier H A Carlos G | 2004 | Environment International2004，30，： | 1 |
| 8 | Secretory phospholipase A2 induces phospholipase Cγ-1 activation and Ca2+mobilization in the human astrocytoma cell line 1321 N1 by a mechanism independent of its catalytic activity显示文摘 | Marita H Maria JB Javier A | 1999 | Biochem Biophys Res Communication1999，260，： | 1 |
| 9 | Magnetic induction tomography: hardware for multi-frequency measurements in biological tissues 显示文摘 | SCHARFETTER H HELMUT K L JAVIER R | 2001 | Physiol Meas2001，22，1： | 1 |
| 10 | Mechanism of kaolinite dissolution at room temperature and pressure, part Ⅱkinetic study显示文摘 | JAVIER H F LEI Chou WOLLAST Roland | 1999 | Geochimica et Cosmochimica Acta1999，63，20： | 1 |
| 11 | Pharmacokinetic–pharmacodynamic modeling of diltiazem in spontaneously hypertensive rats: A microdialysis study显示文摘 | Facundo M. Bertera Marcos A. Mayer Javier A.W. Opezzo Carlos A. Taira Guillermo F. Bramuglia Christian H?cht | 2007 | Journal of Pharmacological and Toxicological Methods2007，，3： | 1 |
| 12 | The molecular pathology of hereditary breast cancer:generic testing and therapeutic implications显示文摘 | Javier B Jos P | 2005 | Modern Pathology2005，18，： | 1 |
| 13 | Operational space trajectory tracking control of robot manipulators endowed with a primary controller of synthetic joint velocity 显示文摘 | Javier M V Luis G H | 2011 | ISATransactions(S0019-0578)2011，50，： | 1 |
| 14 | Non-linear deeay of building stones during freeze-thaw weathering processes 显示文摘 | Javier M M David B Miguel G H | 2013 | Con- struction and Building Materials2013，38，： | 1 |
| 15 | Cloning, expression, and characterization ofavian reovirus guanylytransferase显示文摘 | Joseph H Jose M C Javier B | 2002 | Virology2002，296，2： | 1 |
| 16 | Seroprevalence and national distribution of human toxoplasmosis in Mexico: analysis of the 2000 and 2006 National Health Surveys显示文摘 | Heriberto Caballero-Ortega Felipe Javier Uribe-Salas Carlos J. Conde-Glez Carlos Cedillo-Pelaez José Antonio Vargas-Villavicencio Héctor Luna-Pastén Irma Ca?edo-Solares Luz Belinda Ortiz-Alegría Dolores Correa | 2012 | Transactions of the Royal Society of Tropical Medicine and Hygiene2012，，11： | 1 |
| 17 | Todaro migra- tion and primacy models: Relevance to the urbanization of the Philippines 显示文摘 | Javier Calero Cuervo David H O Kim Hin | 1998 | Cities1998，，4： | 1 |
| 18 | A hierarchical unsupervised growing neural network for clustering gene expression patterns显示文摘 | Javier H Alfonso V Jeaquin D | 2001 | Bioinfomatics2001，17，2： | 1 |
| 19 | Asynahronous development of stigmatic re- ceptivity in the pear(Pyrus communis, Rosaceae) flower显示文摘 | Javier S Pilar R Maria H | 2003 | American Journal of Botany2003，90，1： | 1 |
| 20 | Developing an optimum computer-designed multispectral system comprising a monochrome CCD camera and a liquid-crystal tunable filter 显示文摘 | MIGUEL A ALVAREZ L JAVIER H A | 2008 | Appl Opt2008，47，24： | 1 |
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