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| 1 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 2 | Preparation and Physical Prop- erties of Hollow Glass Microspheres Reinforced Epoxy Matrix Resins显示文摘 | Park S J Jin F L Lee C | 2005 | Materials Science and Engineering A2005，402，2： | 1 |
| 3 | Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion显示文摘 | Bao L Jin SX Zhang C | 2003 | Neuron2003，37，： | 1 |
| 4 | Simultaneous strain and temperature measurement using a highly birefringence fi- ber loop mirror and a long-period grating written in a photonic crystal fiber显示文摘 | Zhao C L Zhao J R Jin W | 2009 | Optics Communication2009，282，： | 1 |
| 5 | Non-lnvasive Glutose Measuring Apparatus Based on Conservation of Energy Method 显示文摘 | Chert Z C Jin X l Zhu J M | 2009 | J Cent South Univ Techno12009，16，： | 1 |
| 6 | An application of the electrochem- ical sulfur sensor in steelmaking 显示文摘 | Hong Y R Jin C J Li L S | 2002 | Sensors and Actuators B2002，87，： | 1 |
| 7 | Using CD133 positive U251 glioblastoma stem cells to establish nude mice model of transplanted tumor 显示文摘 | Jin F Gao C Zhao L | 2011 | Brain Res2011，1368，： | 1 |
| 8 | Void fraction of dispersed bubbly flow in a narrow rectangular channel under rolling conditions显示文摘 | JIN G YAN C SUN L | 2014 | Progress in Nuclear Energy2014，70，： | 1 |
| 9 | Methyl-Cp G-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis显示文摘 | WANG C L DONG X M JIN D | 2015 | Plant physiology2015，167，3： | 1 |
| 10 | Development and application of a simple loop-mediated isothermal amplification method on rapid detection of Listeria monocytogenes strains显示文摘 | WANG L LI Y JIN C | 2012 | Mol Biol Rep2012，，： | 1 |
| 11 | A kinetic analysis of thermal degradation of polymers using a dynamic method显示文摘 | JIN W P SEA C O HAE P L | 2015 | Polymer Degradation andStability2015，67，： | 1 |
| 12 | R2 around the world: new theory and new tests显示文摘 | Jin L Myers S C | 2006 | Journal of Financial Economics2006，79，2： | 1 |
| 13 | Pilot study of a fluidized-pellet-bed technique for simultaneous soild/liquid separation and sludge thickening in a sewage treatment plant 显示文摘 | WANG X C JIN P K YUANG H L | 2004 | Water Science & Technology2004，49，10： | 1 |
| 14 | Structure and photophysical properties of europium complexes of succinamic acid and 1, 10-phenanthroline 显示文摘 | Zheng X J Jin L P Wang Z M Yan C H Lu S Z Li Q | 2003 | Polyhedron2003，22，2： | 1 |
| 15 | Technology opportunities analysis:integrating technology monitoring, forecasting and assessment with strategic planning显示文摘 | Porter A L Jin X-Y Gilmour J E Cunningham S W Xu H Stanard C WangL | 1994 | SRA Journal (Society of Research Administrators)1994，，2： | 1 |
| 16 | Analytical methods for polynomial weighted convolution surfaces with various kernels 显示文摘 | Jin X G Tai C L | 2002 | Computers &Graphics2002，26，3： | 1 |
| 17 | Support vector regression applied tomaterials optimization of sialon ceramics显示文摘 | Liu X Lu W C Jin S L | 2006 | Chemometrics andIntelligent Laboratory Systems2006，82，12： | 1 |
| 18 | Comparative study of anion polyacrylamide (APAM) adsorption-related fouling o a PVDF UF membrane and a modified PVDF UF membrane 显示文摘 | YiXS Shi W X Yu S L Sun N Jin L M Wang S Zhang B Ma C Sun L P | 2012 | Desalination2012，286，： | 1 |
| 19 | Improved bone-forming functionality on diame- ter-controlled Ti02 nanotube surface显示文摘 | Brammer K S Oh S Cobb C J Bjursten L M Heyde H Jin S | 2009 | Acta Biomate- rialia2009，5，8： | 1 |
| 20 | R2 around the world: new theory and new tests 显示文摘 | Jin L Myer S C | 2006 | Journal of Financial Economics2006，79，2： | 1 |
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