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| 1 | 南海红树林内生真菌1356#代谢产物的研究显示文摘从南海红树林内生真菌1356#分离出两种鞘胺醇(A,B)和三种环二肽(C,D,E)?它们的结构通过IR,MS,1D NMR和2D NMR谱推导出来?(3'E,4E)-1-(-D-吡喃葡萄糖基-3-羟基-2-(2'-羟基十八碳酰基)氨基-10-甲基-3',4,9-十八碳三烯(A)是一种新的鞘胺醇甙? | 吴雄宇 林永成 冯爽 姜广策 周世宁 Vrijmoed L L P Jones E B G | 2001 | 热带海洋学报2001，20，4： | 17 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Extracellular matrix and integrin signalling:the shape of things to come显示文摘 | Boudreau N J Jones P L | 1999 | Biochem J1999，339，3： | 2 |
| 5 | Bioreactivity of particulate matter in Beijing air: Results from plasmid DNA assay 显示文摘 | Shao L Y Shi Z B Jones T P | 2006 | Scienceof the Total Environment2006，367，： | 1 |
| 6 | Impacts of harvest residue management on soil carbon stocks in a plantation forest 显示文摘 | Jones H S Garrett L G Beets P N | 2008 | Soil Science Society of America Journal2008，72，6： | 1 |
| 7 | Toxoplasma gondii infection in humans and ani- mals in the United States 显示文摘 | Dubey J P Jones J L | 2008 | Int J Parasitol2008，38，11： | 1 |
| 8 | Methylated DNA and MeCP2 Recruit Histone Deacetylase to Repress Transprition显示文摘 | Jones P L Veenstra G J Wade P A et al | 1998 | Nat Genet1998，19，： | 1 |
| 9 | Influence of boron on carbon fiber microstructure, physical properties, and oxidation behavior显示文摘 | JONES L E THROWER P A | 1991 | Carbon1991，29，2： | 1 |
| 10 | Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: potential interactions during decidualization and trophoblast in- vasion显示文摘 | Jones R L Findlay J K Farnworth P G | 2006 | Endocrinology2006，147，2： | 1 |
| 11 | Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide显示文摘 | P.V O'Donnell L Luznik R.J Jones G.B Vogelsang M.S Leffell M Phelps P Rhubart K Cowan S Piantadosi E.J Fuchs | 2002 | Biology of Blood and Marrow Transplantation2002，，7： | 1 |
| 12 | Competition in denitrification systems affecting the reduction rate and accumulation of nitrite 显示文摘 | Wilderer P A Jones W L Dau U | 1987 | Water Research1987，21，2： | 1 |
| 13 | Biodegradation of low molecular weight organic acids in coniferous forest Podzolic soil显示文摘 | VAN HEES P A W JONES D L GODBOLD D L | 2002 | Soil Biology &Biochemistry2002，34，： | 1 |
| 14 | Twenty-four hour energy expenditure in critically ill patients 显示文摘 | Swinamer D L Phange P T Jones R L | 1987 | Crit Care Med1987，15，7： | 1 |
| 15 | Helicobacter pylori infectionand childhood显示文摘 | Mourad-Baars P Hussey S Jones N L | 2010 | Helicobacter2010，15，1： | 1 |
| 16 | Psychological climate:Dimensions and rela- tionships of individual and aggregated work environment perceptions 显示文摘 | JONES A P JAMES L R | 1979 | Organizational behavior and human performance1979，23，2： | 1 |
| 17 | Free amino sugar reactions in soil in relation to soil carbon and nitrogen cycling 显示文摘 | ROBERTS P BOL R JONES D L | 2007 | Soil Biology and Biochemistry2007，39，： | 1 |
| 18 | The carbon we do not see-the impact of low molecular weight compounds on carbon dynamics and respiration in forest soils: a review显示文摘 | VAN HEES P A W JONES D L FINLAY R | 2005 | Soil Biology : Biochemistry2005，37，1： | 1 |
| 19 | DNA methylation decreases in aging but not in immortal cells显示文摘 | Wilson V L Jones P A | 1988 | Science1988，220，： | 1 |
| 20 | Non-opioid drugs for pain management in labour显示文摘 | Othman M Jones L Neilson J P | 2012 | Cochrane Database Syst Rev2012，7，00： | 1 |
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