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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | The effect of the operating point on the pressure fluctuations at the blade passage frequency in the volute of a centrifugal pump显示文摘 | Jorge L P Jose G Joaquin F | 2002 | Journal of Fluids Engineering2002，124，3： | 1 |
| 3 | Organic and inorganiccarbon in soils of semiarid regions : A case study from the Guadix-Baza ba-sin ( Southeast Spain) 显示文摘 | JOSE L DIAZ-HERNANDEZ A ENRIQUE B F | 2003 | Geoderma2003，114，： | 1 |
| 4 | Determination of phthalate esters in sewage by hemimicelles-based soild-phase extraction and liquid chromatography-mass spectrometry显示文摘 | JOSE F JIMENEZ L RUBIO S | 2005 | Analytica Chimica Acta2005，551，： | 1 |
| 5 | FPGA adaptive optics system test bench 显示文摘 | Rodriguez Ramos L F Viera Teodora Gigante Jose V | 2005 | SPIE2005，5903，： | 1 |
| 6 | Generalized correlation for mass transfer in packed distillation columns 显示文摘 | Jose B L James F R | 1982 | Ind Eng Chem Process Des Dev1982，21，： | 1 |
| 7 | Diesel particulate emis- sions from used cooking oil biodiesel显示文摘 | MAGIN L JOSE R F JOHN R | 2008 | Bioresour Techn- ol2008，99，4： | 1 |
| 8 | Protective effect of carnosol on CCl4 induced acute liver damage in rats 显示文摘 | Jose S L Daniel M F | 2002 | Eur J Gastroenterol Hepatol2002，14，1： | 1 |
| 9 | Changes in growth and in solute concentrations in sorghum leaves and roots during salt stress recovery 显示文摘 | Claudivan F de L Jose C Mareo Antonio O | 2005 | Environmental and Experimental Botany2005，54，： | 1 |
| 10 | The magnitude of copigmentation in the color of aged red wines made in the Canary Islands 显示文摘 | Jacinto D Marta C L Jose F | 2007 | Eur Food Res Technol2007，224，： | 1 |
| 11 | Towards an integrated computational tool for spatial analysis in macroecology and biogeography显示文摘 | Thiago F L Jose A F Luis M B | 2006 | Globle Ecology and Biogeography2006，15，： | 1 |
| 12 | Experimental determination of stress corrosion crack rates and service lives in a buried ERW pipeline显示文摘 | PABLO G F JOSE L O | 2007 | International Journal of Pressure Vessels and Piping2007，84，12： | 1 |
| 13 | Environmental policy in a green market显示文摘 | Jose L M Noemi P F | 2002 | Environmental and Resource Economics2002，22，： | 1 |
| 14 | Simple and sequential extractions of heavy metals from different sewage sludges 显示文摘 | Ana F Mercedes L Jose S | 2004 | Chemosphere2004，54，8： | 1 |
| 15 | Coking Properties of Perhydrous Low-rank Vitrains: Influence of Pyrolysis Conditions显示文摘 | Laggoun-Derfarge F Jean-Noe'l R Jose' Iglesias M | 2003 | Journal of Analytical and Applied Pyrolysis2003，67，： | 1 |
| 16 | Trends in the Structure and Bonding of Noble Metal Clusters 显示文摘 | Eva M F Jose M S M Ignacio L G | 2004 | Phys Rev B2004，70，16： | 1 |
| 17 | A new class of bivariate copulas显示文摘 | Jose Antonio R L Manuel U F | 2004 | Statistics & Probability Letters2004，66，： | 1 |
| 18 | Meat Products as Func- tional Foods:A Review 显示文摘 | Jose M Fernandez G Juana F L | 2005 | Journal of Food Science2005，70，2： | 1 |
| 19 | High phosphorus diet induces vascular calcification,a related decrease in bone mass and changes in the aortic gene expression显示文摘 | Pablo R Natalia C Jose L F | 2010 | Bone2010，46，： | 1 |
| 20 | Simultaneous measurement of strain and tempera-ture using interferometrically interrogated fiber Bragg grating sensors显示文摘 | Ferreira L A Araujo F M Santos Jose L | 2000 | Opt Eng2000，39，8： | 1 |
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