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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020,26,32: | 3 |
| 2 | Critical velocity and burning rate in pool fire during longitudinal ventilation显示文摘 | JAE S R HING S R DONG H K | 2007 | Tunnelling and Underground Space Technology2007,,22: | 1 |
| 3 | Enhancement of optical re- mote sensing images by subband-decomposed multi- scale Retinex with hybrid intensity transfer Function 显示文摘 | Jae H J Sung D K Jong B | 2011 | IEEE Geoscience and Remote Sensing Letters2011,8,5: | 1 |
| 4 | Targeted delivery of low moleculardrugs using chitosan and its derivatives显示文摘 | Jae H P Gurusamy S Kwangmeyung K | 2010 | Advanced Drug Delivery Revie-ws2010,62,: | 1 |
| 5 | Effect of apple pomace on the liver damage in bromobenzene-treated rats显示文摘 | Shin K C Kyeok K Jae H L | 2001 | Food Science and Biotechnology2001,10,3: | 1 |
| 6 | Identification of Epithelial Cell Adhesion Molecule Autoantibody inpatients with Ovarian Cancer显示文摘 | Jae K Dorethee H Kwong K | 2003 | Clinical Cancer Research2003,9,: | 1 |
| 7 | Generalization of linear discriminant analysis using Lp-norm 显示文摘 | JAE H O NOJUN K | 2013 | Pattern Recognition Letters2013,34,6: | 1 |
| 8 | Current status and per- spectives of biopharmaceutical drugs 显示文摘 | JAE K R HYO S K DOO H N | 2012 | Biotechnology and Bioprocess Engineering2012,17,: | 1 |
| 9 | The relationship between cytokines and HPV - 16 ,HPV - 16 E6,E7 and high - risk HPV viral load in the uterine cervix显示文摘 | Seung H S Jae K L O ye S S | 2007 | Gynecol O ncol2007,104,3: | 1 |
| 10 | Modeling and control of an LDPE autoclave reactor显示文摘 | JAE Y H HYUN K R | 1996 | Process Control1996,6,4: | 1 |
| 11 | Wide-viewing-angle inte- gral three-dimensional imaging system by curving a screen and a lens array显示文摘 | YUNHEE K JAE H P SUNG W M | 2005 | Applied Optics2005,44,4: | 1 |
| 12 | Supplementation of standardized lipid-soluble extract from maca (Lepidium meyenii) increases swimming endurance capacity in rats显示文摘 | Eun H C Jung II K Jae Y C | 2012 | Journal of Functional Foods2012,4,2: | 1 |
| 13 | Influence of aggregatesize on the compressive size effect according to differentconcrete types 显示文摘 | JAE I S KEUN H Y JOONG K J | 2013 | Construction and Building Materials2013,,44: | 1 |
| 14 | Highly transparent sapphire micro-grating structures with large diffuse light scattering显示文摘 | YEONG H K JAE S Y | 2011 | Opt Express2011,19,15: | 1 |
| 15 | Vanadosilicate mesoporous SBA-15 molecular sieves incorporated with N-alkylphenothiazines显示文摘 | Zhao H L Jae Y B Larry k | 2000 | Chem Mater2000,12,10: | 1 |
| 16 | Interactive procedure for multiple criteria group decision making with incomplete information显示文摘 | Kim Jae K C Sang H H Chang H K Soung H | 1998 | Computers & Industrial Engineering1998,35,12: | 1 |
| 17 | Supplementation of standardized lipid-soluble extract from maca (Lepidium meyenil) increases swimming endurance capacity in rats显示文摘 | Eun H C Jung I K Jae Y C | 2012 | Journal of Functional Foods2012,4,2: | 1 |
| 18 | Inhibitory effects of garlic and other spices on biogenic amine production in Myeolchijeot, Korean salted and fermented anchovy product显示文摘 | JAE H M YOUNG J K HAN J H | 2009 | Food Control2009,20,5: | 1 |
| 19 | Determination of residual stresses in injection moulded flat plate: simulation and experiments显示文摘 | CHAE H K JAE R Y | 2007 | Polymer Testing2007,26,7: | 1 |
| 20 | Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus显示文摘 | Jong S L Jae Y C Eock K H | 2009 | Carbo Poly2009,78,1: | 1 |