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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Laser clad Ni-base alloy added nano- and micron-size CeO2 composites显示文摘 | Zhang S H Li M X Tong Yul Cho Jae Hong Yoon Chan Gyu Lee and He Y Z | 2008 | Optics & Laser Technology2008，40，5： | 1 |
| 3 | Effect of seepage force on tunnel face stability显示文摘 | Nam S W Jae H A | 2003 | Canadian Geotechnical Journal2003，40，： | 1 |
| 4 | Wide-viewing-angle inte- gral three-dimensional imaging system by curving a screen and a lens array显示文摘 | YUNHEE K JAE H P SUNG W M | 2005 | Applied Optics2005，44，4： | 1 |
| 5 | Bankruptcy prediction using support vector machine with optimal choice of kernel function parameters显示文摘 | Jae H M Y C L | 2005 | Expert Systems with Application2005，28，4： | 1 |
| 6 | Self concept and advertising effectiveness: a conceptual model of congruency, conspicuousness, and response mode 显示文摘 | Zinkhan G M Jae W H | 1991 | Advances in Consumer Research1991，18，1： | 1 |
| 7 | Incorporation of titanium into mesoporous silica molecular sieves SBA-15显示文摘 | Zhao H L Estelle M M Jae Y B | 1999 | Chem Mater1999，11，12： | 1 |
| 8 | Comparison of Ag deposition effects on the photocatalytic activity of nanoparticulate TiO2 under visible and UV light irradiation 显示文摘 | HYUNG M S-S JAE R C HOE J H | 2004 | Journal of Photochemistry and Photobiology A: Chemistry2004，163，： | 1 |
| 9 | Inhibitory effects of garlic and other spices on biogenic amine production in Myeolchijeot, Korean salted and fermented anchovy product显示文摘 | JAE H M YOUNG J K HAN J H | 2009 | Food Control2009，20，5： | 1 |
| 10 | Perfusion MR imaging in gliomas: comparison with histologic tumor grade显示文摘 | Sun J Jae H Young M | 2001 | Korean J Radiol2001，2，1： | 1 |
| 11 | A combinatorial approach to hybrid enzymes independent of DNA homology 显示文摘 | Ostermier M Jae H S Stephen J B | 1999 | Nat Biotechnol1999，17，12： | 1 |
| 12 | Non-linear shape-finding analysis ofa self-anchored suspension bridge 显示文摘 | Kyung H K Jae M L Pil S C | 2002 | Engineer Structures2002，24，： | 1 |
| 13 | Use of a fuzzy decision-making method in evaluating severe accident management strate- gies显示文摘 | JAE M MOON J H | 2002 | Annals of Nuclear Energy2002，29，： | 1 |
| 14 | Effect of dry and wet milled rice flours on the quality attributes of gluten-free dough and noodles显示文摘 | SOOJUNG H SEUNG M L JAE HOON S | 2013 | Journal of Food Engineer-ing2013，116，： | 1 |
| 15 | Influence of Sn content on Pt-Sn/C catalysts for electrooxidation of C1-C3 alcohols: Synthesis, characterization and electrocatalytic activity显示文摘 | Jae H K Sung M C Sang H N | 2008 | Applied Catalysis B : Environmental2008，82，2： | 1 |
| 16 | Effect of seepage force on tunnel face stability 显示文摘 | Lee I M Nam S W Jae H A | 2003 | Canadian Geotechnical Journal2003，40，2： | 1 |
| 17 | Extinction coefficients of hemoglobin for near-infrared spectroscopy of tissue显示文摘 | Jae G K Xia M N Liu H L | 2005 | IEEE Engineering in Medicine and Biology Magazine2005，4，3： | 1 |
| 18 | Bankruptcy prediction using support vector machine with optimal choice of kernel function parameters显示文摘 | Jae H M Y C L | 2005 | Expert Systems with Application2005，28，3： | 1 |
| 19 | J Mere Sci显示文摘 | Jae H K Yong M L | 2001 | 193:2092001，193，： | 1 |
| 20 | Self concept and advertising effectiveness: a conceptual model of congruency conspicuousness, and response mode 显示文摘 | GEORGE M Z JAE W H | 1991 | Advances in Consumer Research1991，18，3： | 1 |
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