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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 3 | 显示文摘 | Jason C Wayne D Mader J T | 1988 | J Bone Joint Surg (Am)1988，70，： | 1 |
| 4 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 5 | Seismic assessment of concentrically braced steel frames with shape memory alloy braces 显示文摘 | JASON M C REGINALD D R | 2007 | Journal of Structural Engineering2007，133，6： | 1 |
| 6 | Mutational analysis of the pullulanase-type debranching enzyme of maize indicates multiple functions in starch metabolism 显示文摘 | Jason R D Christophe C Martha G J | 2003 | Plant Cell2003，15，： | 1 |
| 7 | Comparison of a bacteriophage-delivered DNA vaccineand acommercially available recombinant protein vac-cine against hepatitis B显示文摘 | Jason R C Kathryn Bartley Catherine D J | 2011 | Fems Immunol Med Micro-biol2011，61，： | 1 |
| 8 | Optimal struc- ture, market dynamism, and the strategy of simple rules显示文摘 | Jason P D Kathleen M E Bingham C B | 2009 | Administrative Science Quarterly2009，54，3： | 1 |
| 9 | Circulat- ing and dietary magnesium and risk of cardiovascular disease:A systematic review and meta-analysis of pro- spective studies 显示文摘 | Liana C D G Fumiaki I Jason H Y W | 2013 | Am J Clin Nutr2013，98，1： | 1 |
| 10 | Loss of INI 1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma显示文摘 | Jason H L Paola D C Christopher F D M | 2009 | Am J Surg Pathol2009，33，4： | 1 |
| 11 | Ancient sex-specific extension of the cytochrome c oxidase Ⅱ gene in Bivalves and the Fidelity of doubly-uniparental inheritance 显示文摘 | JASON P C THOMAS D K | 2002 | Molecular Biology and Evolution2002，19，8： | 1 |
| 12 | Deposition and annealing of lead scandium tantalite thin films for high performance thermal detector arrays 显示文摘 | MIKE A T PAUL P D JASON C J | 1999 | Integrated Ferroelectrics1999，25，： | 1 |
| 13 | Formation and control of box-shaped ultra-shallow junction using laser annealing and pre-amorphization implantation显示文摘 | Kim S D Park C M Jason C S W | 2005 | Solid-State Electronics2005，49，1： | 1 |
| 14 | Deposition and annealing of lead scandium tantalate thin films for high performance thermal detector arrays显示文摘 | Mike A T Paul P D Jason C J | 1999 | Integrated Ferroelectrics1999，25，： | 1 |
| 15 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 16 | Devel- opment and application of a muhimodal contrast ggent for SPECT/CT hybrid imaging 显示文摘 | Jason M C Lawrence W D Zhen W Z etal | 2011 | Bioconjug Chem2011，22，： | 1 |
| 17 | Imaging with terahertz radiation显示文摘 | WAI L C JASON D DANIEL M M | 2007 | Rep Prog Phys2007，70，： | 1 |
| 18 | SCR catalyst performance in flue gases derived from subbituminous and lignite coals 显示文摘 | STEVEN A B JASON D L CHARLENE R C | 2005 | Fuel Processing Technology2005，86，： | 1 |
| 19 | A model for oxidation aging of rubber-modified asphalt and implications to performance analysis显示文摘 | Jason F C Richard R D | 2001 | Energy & Fuels2001，4，15： | 1 |
| 20 | The effect of employee trust of the supervisor on enterprising behavior:a cross-cultural comparison显示文摘 | ROBERT C D RICHARD I C JASON B J SELIM I S ET AL | 2006 | Journal of Business and Psychology2006，，21： | 1 |
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