4篇
您的检索式：作者名="Jay Thomas"
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| 1 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 2 | Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Mortality and Identifies Acute Kidney Injury in Cirrhosis显示文摘 | Elizabeth Verna Robert Brown Erica Farrand Elsa Pichardo Catherine Forster David Sola-Del Valle Sarah Adkins Meghan Sise Juan Oliver Jai Radhakrishnan Jonathan Barasch Thomas Nickolas | 2012 | Digestive Diseases and Sciences2012，，9： | 1 |
| 3 | A genetic linkage map of a ciehlid fish, the tilapia (Oreochromis niloticus)显示文摘 | THOMAS D KOCHERA WOO - JAI LEE HALINA SOBOLEWSKA ct al | 1998 | Genetics1998，148，： | 1 |
| 4 | Eliciting conditioned taste aversion in lizards:Live toxic prey are more effective than scent and taste cues alone显示文摘Conditioned taste aversion(CTA)is an adaptive learning mechanism whereby a consumer associates the taste of a certain food with symptoms caused by a toxic substance,and thereafter avoids eating that type of food.Recently,wildlife researchers have employed CTA to discourage native fauna from ingesting toxic cane toads(Rhinella marina),a species that is invading tropical Australia.In this paper,we compare the results of 2 sets of CTA trials on large varanid lizards(“goannas,”Varanus panoptes).One set of trials(described in this paper)exposed recently-captured lizards to sausages made from cane toad flesh,laced with a nausea-inducing chemical(lithium chloride)to reinforce the aversion response.The other trials(in a recently-published paper,reviewed herein)exposed free-ranging lizards to live juvenile cane toads.The effectiveness of the training was judged by how long a lizard survived in the wild before it was killed(fatally poisoned)by a cane toad.Both stimuli elicited rapid aversion to live toads,but the CTA response did not enhance survival rates of the sausage-trained goannas after they were released into the wild.In contrast,the goannas exposed to live juvenile toads exhibited higher long-term survival rates than did untrained conspecifics.Our results suggest that although it is relatively easy to elicit short-term aversion to toad cues in goannas,a biologically realistic stimulus(live toads,encountered by free-ranging predators)is most effective at buffering these reptiles from the impact of invasive toxic prey. | Georgia WARD-FEAR Jai THOMAS Jonathan K.WEBB David J.PEARSON Richard SHINE | 2017 | Integrative Zoology2017，12，2： | 0 |
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