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| 1 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 2 | 经颈内静脉肝内门腔分流术远期疗效分析显示文摘目的:探讨经颈静脉肝内门脉分流术(TIPS)后病人的远期分流道通畅率,生存期和生活质量。材料及方法:51例TIPS术后病人,随访时间平均为16.8±12.8月(1天-49月),用Kaplan-Meier法分析TIPS后病人的远期生存率,和分流道通畅率。用COX模型将生存期和通畅率与Child~Pugh肝功能分级和主要症状作相关分析,并预测影响生存期和分流道通畅率的因素。用SF~36问卷评估病人的生活质量。结果:1-4年累计生存率分别为65%,56%,32%,19%。累计原发通畅率分别为65%,56%,32%,19%。42个月原发再次通畅率为94%,18个月4继发通畅率为7l%。肝功能Child-Pugh分级与累积生存率有显著性差异。影响TIPS术后90天生存率的相关因素有:酒精性肝硬化,腹水,急性出血,分流腔道直径,静脉曲张需栓塞者,肝性脑病,分流通道再狭窄及再发出血。TIPS术后生活质量的所有9项指标均较术前提高,其中4项有显著性差异。结论:TIPS对控制出血,腹水及改善近期生活质量有肯定的疗效,但是对病人远期生活率的确切作用尚有待于进一步的研究。 | 滕皋军 Michael A Bettmann Robert F Jeffery James K St.George | 1997 | 介入放射学杂志1997，6，3： | 3 |
| 3 | Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray显示文摘 | Wang K Gan L Jeffery E | | 0，，： | 2 |
| 4 | Disruption of a new forkhead/winged protein, scurfin, results in the fatal lympho-proliferatire disorder of the scurfy mouse显示文摘 | Brunkow M E Jeffery E W Hierrild K A | 2001 | Nat Genet2001，27，1： | 1 |
| 5 | Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension显示文摘 | Wanstall J C | 2001 | Pharmacol Thera Peutics2001，92，： | 1 |
| 6 | Patterns of recombination in turnip mosaic virus genomic sequences indicate hotspots of recombination显示文摘 | Ohshima K Tomitaka Y Jeffery T | 2007 | J Gen Virol2007，88，： | 1 |
| 7 | Dyeing paper with a new class of cationic colorants显示文摘 | Crounse P Jefferies P J Moore E K | 1975 | Tappi 11975，，： | 1 |
| 8 | Pulmonary vascular remodehng: a target for therapeutic intervention in pulmonary hypertension 显示文摘 | Jeffery T K Wanstall J C | 2001 | Pharmacol Ther2001，92，1： | 1 |
| 9 | Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease显示文摘 | Jeffery P K | 2004 | Proc Am Thorac Soc2004，1，： | 1 |
| 10 | Oat germiuation characteristics differ among genotypes,seed sizes and osmotic potentials显示文摘 | CHRISTIAN J W JEFFERY C W ARON K M | 2005 | Crop Science2005，45，： | 1 |
| 11 | Lymphocytes,chronic bronchitis and chronic obstructive pulmonary disease显示文摘 | Jeffery P K | 2001 | Novartis Found Symp2001，234，： | 1 |
| 12 | Pulmonary vascular remodeling:a target for therapeutic intervention in pulmonary hypertension显示文摘 | JEFFERY T K WANSTALL J C | 2001 | Pharmacol Ther2001，92，： | 1 |
| 13 | A multi-population genetic algorithm to solve multi-objective scheduling problems for parallel machines显示文摘 | Jeffery K C Shwu-min Hong John W F | 2003 | Computer & Operations Research2003，30，： | 1 |
| 14 | A state parameter for sands 显示文摘 | Been K Jefferies M G | 1985 | Geotechnique1985，35，2： | 1 |
| 15 | Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function显示文摘 | Wanstall J C | 1999 | Br J Pharmacol1999，128，： | 1 |
| 16 | The critical state of sands显示文摘 | BEEN K JEFFERIES M G | 1991 | Geotechnique1991，41，3： | 1 |
| 17 | Monitoring gene expression profile changes in ovarian carcinomas using CDNA microarray 显示文摘 | Wang K Gan L Jeffery E | 1999 | Gene1999，229，： | 1 |
| 18 | InfIuenza,The Once and Future Pandemic 显示文摘 | Jeffery K Taubenberger M D David M | 2010 | The science of influenza2010，125，1： | 1 |
| 19 | Pulmonary vascular remodeling in hypoxic rats: effects of amlodipine, alone and with perindopril显示文摘 | Wanstall J C | 2001 | Eur J Pharmacol2001，416，： | 1 |
| 20 | Differential effects of TGFbetal and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells显示文摘 | Sheares K K Jeffery T K Long L | 2004 | Am J Physiol Lung Cell Mol Physiol2004，287，5： | 1 |
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