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| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | PDF simulations of a bluff-body stabilized flow显示文摘 | Jenny P Pope S B Muradoglu M | 2001 | J Comp Phys2001，166，： | 2 |
| 3 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 4 | Value and Risks of Expiring Carbon Credits from Afforestation and Reforestation Projects under the CDM显示文摘 | Michael D Bernahard S Jenny L P W | 2005 | Climate Policy2005，5，1： | 1 |
| 5 | Mortality in Pennsylvania 显示文摘 | Arthur L H Daniel captive elk ( Cervus 2007 19(3) : 334 P S Jenny S F elaphus) : 1998-2006 -337 | 2007 | J Vet Diagn Invest2007，，： | 1 |
| 6 | Managing reuse in manufacturing system modelling and design:a value net approach显示文摘 | Dant Shilpa S Harding Jenny A | 2004 | International Journal of Computer Integrated Manufacturing2004，17，3： | 1 |
| 7 | Serum amyloM P and cardiovascular disease in older men and women:results from the Cardiovascular Health Study显示文摘 | Jenny N S Arnold A M Kuller L H | | 0，，02： | 1 |
| 8 | A simple intervention to improve hospital antibiotic prescribing 显示文摘 | Michael S Jenny R Michael S | 2003 | MJA2003，178，： | 1 |
| 9 | Unconventional shallow biogenic gas systems 显示文摘 | George W S Jennie L R | 2002 | AAPG Bulletin2002，86，11： | 1 |
| 10 | INCITE:A randomised trial comparing constraint induced movement therapy and bimanual training in children with congenital hemiplegia 显示文摘 | Roslyn B Leanne S Jenny Z | 2010 | BMC Neurology2010，10，4： | 1 |
| 11 | Adaptive fully implicit multi-scale finite-volume method for multi-phase flow and transport in heterogeneous porous media显示文摘 | JENNY P LEE S TCHELEPI H | 2006 | Journal of Computational Physics2006，217，2： | 1 |
| 12 | Participa- tion of vasoactive intestinal polypeptide in ovarian ster- oids production during the rat estrous cycle and in the development of estradiol valerate-induced polycystic ova- ry显示文摘 | Claudio Parra Jenny L F Leticia S Luna | 2007 | Biol Reprod2007，133，1： | 1 |
| 13 | Adaptive multiscale finite-volume method for muhiphase flow and transport in porous media 显示文摘 | JENNY P LEE S TCHELEPI H | 2005 | Multiseale Modeling & Simulation2005，3，1： | 1 |
| 14 | Comparative study of decomposition rates of organic matter in temperate and tropical regions显示文摘 | Jenny H Gesel S P Bingham F T | 1989 | Soil Sci1989，68，： | 1 |
| 15 | Metallo-organic low-pressure chemical vapor deposition of Ta2O5 using TaC12H30O5N as precursor for batch fabrication of microsystems显示文摘 | Briand D Mondin G Jenny S | 2005 | Thin Solid Films2005，493，12： | 1 |
| 16 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 17 | Adaptive fully implicit multi-scale finite-volume method for multi-phase flow and transport in heterogeneous porous media 显示文摘 | JENNY P LEE S H TCHELEPI H A | 2006 | Journal of Computational Physics2006，217，2： | 1 |
| 18 | The composition of un- recorded alcohol from eastern Ukraine: Is there a toxicological concern beyond ethanol alone?显示文摘 | DIRK W L ANDRIY V S JENNY | 2010 | Food Chem Toxicol2010，48，： | 1 |
| 19 | Stable carbon (12/13 C) and nitrogen (14/15N) isotopes as a tool for ide~ntifying the sources of cyanide in wastes and contaminated soils-A methoddevelopment 显示文摘 | JENNY W TIM M ULRIKE S | 2007 | Analytica Chimica Acta2007，582，： | 1 |
| 20 | No drainage does not increase thecomplication risk after total knee prosthesis implantation: apro-spective,comparative, randomized study 显示文摘 | Jenny J Boeri C Lafare S | 2001 | Knee SurgSports Traumatol Arthrose2001，9，5： | 1 |
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