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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Hem odynam ic changes during laparoscopic cholecystectomy显示文摘 | Joris J L Noirot D P Legrand M J | 1993 | Aneath Analg1993，76，5： | 1 |
| 3 | Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte显示文摘 | Palermo G Joris H Devroey P | 1992 | Lancet1992，340，8810： | 1 |
| 4 | Effects of different hyaluronidase concentrations and mechanical procedures for cumulus cell removal on the outcome of intracytoplasmic sperm injection显示文摘 | Van H Nagy Z P Joris H | 1997 | Human Reproduction1997，12，10： | 1 |
| 5 | Pregnancies after intracytoplasmic injection of a single spermatozoon into an oocyte 显示文摘 | Palermo G Joris H Devroey P | 1992 | Lancet1992，340，1： | 1 |
| 6 | Pain after laparoscopic cholecystectomy:characteristics and effect of intraperitoneal bupivacaine显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，： | 1 |
| 7 | Acute renal failure requiring haemodialysis after high doses percutaneous acetic acid injection for hepatocellular carcinoma显示文摘 | Van Hoof M Joris J P Horsmans Y | 1999 | Acta Gastroenterol Belg1999，62，1： | 1 |
| 8 | Pregnancies after intracytoplasmic injection of single spermatozoonintoan oocyte显示文摘 | Palermo G Joris H Devroey P | 1992 | Lancet1992，340，8810： | 1 |
| 9 | Early application of CPAP in newborns with gestational age below 34 weeks lower sintubation rate and shortens oxygen therapy without altering mortality and morbidity显示文摘 | Joris H Sudre P Moessinger A | | 0，，49： | 1 |
| 10 | Pain after laparoscopic cholecystectomy:characteristics and effect of intraperitoneal bupivacaine显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，2： | 1 |
| 11 | Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte显示文摘 | Palermo G Joris H Devroey P | 1992 | Lancet1992，340，8810： | 1 |
| 12 | Pain after laparoscopic cholecystectony; characteristics and effect of intraperitoneal bupivaeaine 显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，： | 1 |
| 13 | Subjective and Objective Knowledge as Determinants of Organic Vegetables Consumption 显示文摘 | Zuzanna P Joris A Wim V | 2010 | Food Quality and Preference2010，21，6： | 1 |
| 14 | Early application of CPAP in newborns with gestational age below 34 weeks lowers intubation rate and shortens oxygen therapy without altering mortality and morbidity显示文摘 | Joris N Sudre P Moessinger A | | 0，，49： | 1 |
| 15 | Molecular path- ways involved in neural in vitro differentiation of marrow stromal stem cells显示文摘 | Jori F P Napolitano M A Melone M A | 2005 | J Cell Biochem2005，94，4： | 1 |
| 16 | Intracytoplasmic single sperm injection of 1-day-old unfertilized human oocytes显示文摘 | NAGY Z P JORIS H LIU J | | 0，，12： | 1 |
| 17 | Pregnancies after intracytoplasmic injection of a single apermatogoon into an oocyte 显示文摘 | Palermog Joris H Derroy P st al | 1992 | Lancet1992，340，1： | 1 |
| 18 | Bacterialpepfidoglycan (murein) hydrolases 显示文摘 | VOLLMER W JORIS B CHARLIER P | 2008 | FEMS Microbiology Reviews2008，32，： | 1 |
| 19 | Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte显示文摘 | Joris H Devroey P | 1992 | Lancet1992，340，8810： | 1 |
| 20 | Pregnancies after intracytoplasmic injection of a single spermatozoo into an oocyte显示文摘 | Palermo G Joris H Devroey P | 1992 | Lancer1992，340，1： | 1 |
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