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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | The magnitude of eopigmentation in the colour of aged red wines made in the Canary Islands 显示文摘 | Jacinto D M Marta C L Jose Federico E G | 2007 | Eur Food Res Techno12007，224，5： | 1 |
| 3 | Electrochemical production and corrosion testing of am orphous Ni-P显示文摘 | Jose L C Ralph E W | 1988 | J Electro- chem Soc1988，135，12： | 1 |
| 4 | Angioplasty and Stent Placement in Intraeranial Atherosclerotie Stenoses and Dissections显示文摘 | Jose E Cohen C | 2002 | AJNR Am J Neuroradio12002，23，： | 1 |
| 5 | Synthesis and dielectric characteristics of the layered structure Bi4-xRxTi3O12 (Rx=Pr,Nd,Gd,Dy)显示文摘 | JOSE L PINEDA-FLORESA E CHAVIRAA J | 2003 | J Eur Ceram Soc2003，23，： | 1 |
| 6 | Tillage effects on soil properties and crop production in the sub-humid and semiarid Argentinean Pampas 显示文摘 | Daniel E B Jose L P Paul W U | 1998 | Soil & Tillage Res1998，49，： | 1 |
| 7 | Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans显示文摘 | Jose E G Maria L M Andrea M | 2014 | Metabolism Clinical and Experimental2014，63，： | 1 |
| 8 | Organizational Learning Dynamics in the Software Publishing Industry显示文摘 | Pedro L Gregorio M Jose E N | 2008 | International Journal of Technology Management2008，41，12： | 1 |
| 9 | Schedulability analysis of real -time traffic in WorldFIP networks: an integrated approach 显示文摘 | ALMEIDA L TOVAR E JOSE A | 2002 | IEEE Transactions on Industrial Electronics2002，49，5： | 1 |
| 10 | Aromatic polyamides with benzothiazole pendent groups: synthesis, nuclear mag- netic resonance structural study and evaluation of properties 显示文摘 | ANGEL E L JOSE G C JAVIER A | 1994 | Polymer1994，35，4： | 1 |
| 11 | Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi显示文摘 | Christopher S E Jose R V Nicole L S | 2011 | Plos Negl Trop Dis2011，5，3： | 1 |
| 12 | Diagnosis of tuberculousp leurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon 显示文摘 | Valdes L San Jose E Alvarez D | 1993 | Chest1993，103，： | 1 |
| 13 | Diagnostic value of aden-osine deaminase and ysozyme in tuberculous pleurisy 显示文摘 | San Jose E Valdes L Sarandeses A | 1992 | Clin Chem Acta1992，209，12： | 1 |
| 14 | Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon-gamma显示文摘 | Valdes L San Jose E Alvarez D | 1993 | Chest1993，103，： | 1 |
| 15 | Barriers to internal rotation in β-methyl-γ-butyrolactone,3-methylcyclopentanone,and γ-valerolactone from fourier transform microwave spectroscopy显示文摘 | Charro E M Jose A L | | 0，，02： | 1 |
| 16 | Multiresidue analysis of quinolones and fluoroquinolones in soil by ultrasonic - assisted extraction in small colunms and HPLC - UV显示文摘 | ESTHER T ANTONIO M E JOSE L T | 2006 | Analytica Chimica Acta2006，562，： | 1 |
| 17 | Electrochemical production and corrosion testing of amorphous Ni-P显示文摘 | Carbajal Jose L White Ralph E | 1988 | J Electrochem Soc1988，135，12： | 1 |
| 18 | Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions显示文摘 | Valdes L San Jose E Alvarez Dobafio JM | 2009 | Eur Respir J2009，33，4： | 1 |
| 19 | Immune response to fungal infec- tions 显示文摘 | Jose L Blaneo Marta E Gareia | 2008 | Veterinary Immunology and Immunopathology2008，，9： | 1 |
| 20 | Tuberculous pleurisy: a study of 254 patients 显示文摘 | Valdes L Aivarez S San Jose E | 1998 | Arch Intern Med1998，158，8： | 1 |
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