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| 1 | Rare complications of pediatric diabetic ketoacidosis显示文摘The incidence of type 1 diabetes(T1D) among youth is steadily increasing across the world. Up to a third of pediatric patients with T1 D present with diabetic ketoacidosis, a diagnosis that continues to be the leading cause of death in this population. Cerebral edema is the most common rare complication of diabetic ketoacidosis in children. Accordingly, treatment and outcome measures of cerebral edema are vastly researched and the pathophysiology is recently the subject of much debate. Nevertheless, cerebral edema is not the onlysequela of diabetic ketoacidosis that warrants close monitoring. The medical literature details various other complications in children with diabetic ketoacidosis, including hypercoagulability leading to stroke and deep vein thrombosis, rhabdomyolysis, pulmonary and gastrointestinal complications, and long-term memory dysfunction. We review the pathophysiology, reported cases, management, and outcomes of each of these rare complications in children. As the incidence of T1 D continues to rise, practitioners will care for an increasing number of pediatric patients with diabetic ketoacidosis and should be aware of the various systems that may be affected in both the acute and chronic setting. | Shara R Bialo Sungeeta Agrawal Charlotte M Boney Jose Bernardo Quintos | 2015 | World Journal of Diabetes2015，6，1： | 9 |
| 2 | Soil boron fertilization:The role of nutrient sources and rootstocks in citrus production显示文摘Boron(B) is a key element for citrus production, especially in tropical regions, where the nutrient availability is commonly low in the soil. In addition, information about doses, fertilizer sources, methods of application, and particularly, differential nutrient demand of scion/rootstock combinations are required for efficient fertilization of commercial groves. In a non-irrigated sweet orange orchard(cv. Natal), grafted onto Rangpur lime, Swingle citrumelo or Sunki mandarin, we studied the application of two sources of B: boric acid(17% B, soluble in water) and ulexite(12% B, partially soluble in water) at four levels of supply(control without B, and soil application of 2, 4 and 6 kg ha^(-1) yr^(-1) of B). The experiment was carried out for three years(2004-2006). Boron availability in the soil and concentration in the leaves, as well as the fruit yield and quality of trees were evaluated. Soil B extracted with hot water and total leaf B positively correlated with doses of the nutrient applied to the trees. Levels of B in the soil and in the leaves did not vary with fertilizer sources. Fruit yield of trees grafted onto Rangpur lime and Swingle citrumelo was more responsive to B doses than those grafted onto Sunki mandarin. The maximum fruit yield of trees grafted onto Swingle was obtained with 3.2 kg ha^(-1) yr^(-1) of B, and leaf B level of 280 mg kg^(-1) that point out to a highest demand for B when this combination was compared with other rootstocks. Furthermore, fertilization with B did not affect the quality of fruits, but correlated with B and potassium(K) concentrations in the leaves. These results also support that the current recommendations for levels of B in leaves should be revisited. | Dirceu Mattos Jr Franz W R Hippler Rodrigo M Boaretto Eduardo S Stuchi Jose A Quaggio | 2017 | Journal of Integrative Agriculture2017，16，7： | 5 |
| 3 | Liver preservation prior to transplantation: Past, present, and future显示文摘Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 4 |
| 4 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 5 | Pyrolysis of sawdust in a conical spouted bed reactor: yields and product composition显示文摘 | Aguado R Olazar M Jose M | 2000 | Ind Eng Chem Res2000，39，： | 1 |
| 6 | Feasibility of treating partially soluble wastewater in anaerobic sequencing batch biofilm reactor (ASBBR) with mechanical stirring显示文摘 | SAMANTHA C P SUZANA M R JOSE A D | 2005 | Bioresource Technology2005，96，4： | 1 |
| 7 | A study ofawareness in multimedia search显示文摘 | Villa R Jose J M | | 0，，01： | 1 |
| 8 | Arginine addition in the sta- tionary phase influences the fermentation rate and synthesis of aroma compounds in a synthetic must fermented by three commercial wine strains 显示文摘 | GUTIERREZ A CHIVA R JOSE M G | 2015 | LWT-Food Sei Technol2015，60，2： | 1 |
| 9 | On Farmers' Objective:A MultiCriteria Approach显示文摘 | Francisco A Jose M S Carlos R | 1996 | European Journal of Operational Research1996，96，： | 1 |
| 10 | A Monte-Carlo simulation approach for approximating multi-state two-terminal reliability 显示文摘 | Jose E R M David W C | 2005 | Reliability Engineering and Systems Safety2005，87，2： | 1 |
| 11 | Manipulation of Strawberry Fruit Softening by Antisense Expression of a Pectate Lyase gene显示文摘 | SILVIA J B JOSE R N JUAN M B | 2002 | Plant Physiol2002，，128： | 1 |
| 12 | Mathematical morphology for de- sign and manufacturing 显示文摘 | Antonio J M Rafael M C Jose S R | 2011 | Mathematical and Computer Modelling2011，54，78： | 1 |
| 13 | Lumen loading with calcium carbonate fillers显示文摘 | Middleton Steven R Desmeules Josee Scallan Anthony M | 2003 | Journal of Pulp and Paper Science2003，29，7： | 1 |
| 14 | Photocatalytic water splitting on Au/TiO2 nanocomposites synthesized through various routes:Enhancement in photocatalytic activity due to SPR effect显示文摘 | Sadhana S R Jose D Joshi M V | | 0，，： | 1 |
| 15 | Wax for- marion in the pyrolysis of polyolefins in a conical spouted bed reactor 显示文摘 | AGUADO R OLAZAR M SAN JOSE M J | 2002 | Energy fuels2002，16，6： | 1 |
| 16 | 显示文摘 | Merceds R Jose M Jordi F | 2000 | Thromb Haemost2000，84，2： | 1 |
| 17 | Appli- cation of conventional solid-phase extraction for multimycotoxin analysis in beers by ultra- high-performance liquid chromatography-tandem mass spectrometry 显示文摘 | Roberto R G Jose L M Aguilera M M | 2009 | Journal of Agricultural and Food Chemistry2009，57，20： | 1 |
| 18 | Nanostructured Nb2O5 polymorphs by electrospinning for rechargeable lithium batterries显示文摘 | VIET A L REDDY M V JOSE R | 2010 | The Journal of Physical Chemistry C2010，114，1： | 1 |
| 19 | A method for calibration and validation subset partitioning 显示文摘 | Galvao R K H Araujo M C U Jose G E | 2005 | Talanta2005，67，4： | 1 |
| 20 | On an optimal control design for Rssler system显示文摘 | JOSE M B | 2004 | Physics Letters A2004，333，： | 1 |
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