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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | On the syn- thesis of a-zirconium phosphate 显示文摘 | CAMINO T SERGEI A K JOSE R G | 2000 | Chem Mater2000，12，6： | 1 |
| 3 | Kinetic modeling of enzymatic saccharification using wheat straw pretreated under autohydrolysis and organosolv process 显示文摘 | Hector A R Antonio A V Jose A T | 2012 | Industrial Crops and Products2012，36，1： | 1 |
| 4 | Amino functionalized chitosan as a catalyst for selective solvent-free self-condensation ol linear aldehydes 显示文摘 | JOSE T SUDHEESH N SHUKLA R S | 2010 | Journal of Molecular Calalysis A: Chemical2010，333，12： | 1 |
| 5 | Antimicrobial and healing activity of Kefir and Kefiranextract 显示文摘 | Kamila L R Lucelia Rita G C Jose Carlos T C | 2005 | International Journal of Antimicrobial Agents2005，25，： | 1 |
| 6 | High Temperature Mechanical Behavior of a 30% Ni - 19% Cr Steel 显示文摘 | Jose A J Oscar A R Maria T L | 2003 | ISIJ International2003，，12： | 1 |
| 7 | Confirmation of fluoroquinolones in catfish muscle by electrospray liquid chromatography / mass spectrometry显示文摘 | Sherri B T Calvin C W Jose E R | 1998 | J AOAC Iut1998，81，3： | 1 |
| 8 | Identification of new landslides from high resolution satellite data cover- ing a large area using object-based change detection methods显示文摘 | Martha T R Kamala P Jose J | 2016 | Indian Society of Remote Sensing2016，44，1： | 1 |
| 9 | Synthesis and characterization of Schiff bases from ehitosan and salicylaldehyde derivatives显示文摘 | Jose E dos Santos Edward R Dockal Eder T G Cavalheiro | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 10 | How can H content influence the tribological behaviour of W-containing DLC coatings显示文摘 | MOURA E SILVA CARLOS W BRANCO JOSE R T CAVALEIRO ALBANO | 2009 | Solid State Sciences2009，11，10： | 1 |
| 11 | Industrial and biotechnological applications of laccase: A review 显示文摘 | Susana R C Jose L T H | 2006 | Biotechnology Advances2006，24，： | 1 |
| 12 | Confirmation of fluoroquinolones in catfish muscle by electrospary liquid chromatogra- phy mass spectrometry显示文摘 | SHERRI B T CALVIN C W JOSE E R | 1998 | J AOAC Int1998，8，3： | 1 |
| 13 | Electron transport in dectmspun TiO2 nanofiber dye-sensitized solar cells显示文摘 | Mukherjee K Teng T Jose R | 2009 | Applied Physics Letters2009，95，01： | 1 |
| 14 | Dosimetric Properties of Rare Earth Doped LiCaBO3 Thermoluminescence Phosphors显示文摘 | Anishia S R Jose M T Annalakshmi O | 2010 | J Lumin2010，130，10： | 1 |
| 15 | Cathepsin B, D, H and L activities in the proce ssing of dry-cured ham 显示文摘 | Fidel T Elias R Jose F | 1993 | J Sci Food Agric1993，62，： | 1 |
| 16 | Effect of C and Mn Varia- tions upon the Solidification Mode and Surface Cracking Susceptibili- ty of Peritectic Steels 显示文摘 | Eddy A L Martn H T Jose J R M | 2009 | ISIJ International2009，49，6： | 1 |
| 17 | Low-salt restructured fish products using microbial transglutaminase as binding agent显示文摘 | Simon J T Rocio M U Jose A R | 2002 | Jourual of Science of Food and Agriculture2002，，82： | 1 |
| 18 | Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitisidaea and Maytenus spinosa 显示文摘 | Maria T R de A Carla R L Jose M P | 2010 | Phytochemistry2010，71，1415： | 1 |
| 19 | Dosimetric properties of rare earth doped LiCaBO3 thermo luminescence phosphors显示文摘 | Anishia S R Jose M T Annalakshmi O Ponnusamy V Ramasamy V | | 0，，： | 1 |
| 20 | Gas Chromatographic/MS spectrometric confirmation of leucomalachite green in catfish tissue 显示文摘 | Sherri B T Jose E R Jeffrey A H | 1995 | Journal of AOAC International1995，78，4： | 1 |
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