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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 3 | Uniform persistence and Repellors for Maps显示文摘 | HOFBAUER J JOSEPH W H SO | 1989 | Proceedings of the American Mathematical Society1989，107，4： | 1 |
| 4 | U- Pb zircon and geochemical evidence for bimodal mid-Paleozoic magmatism and syngenetic base-metal mineralization in the Yukon-Tanana terrane,Alaska显示文摘 | Cynthia D B Joseph L W Melanie J H | | 0，，7： | 1 |
| 5 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 6 | A new method for solving equilibrium problem fixed point problem and Variational inequality problem with application to optimization显示文摘 | Chang S S Joseph Lee H W Chan Chi Kin | 2009 | Nonlinear Anal:TMA2009，70，9： | 1 |
| 7 | An Octahedral Template Based on a New Molecular Turn:Synthesis and Structure of a Model Complex and a Reactive,Diphenolic Ligand and Its Metal Complexes显示文摘 | Andrew L V Nathaniel W A Joseph A H | 1998 | Inorg Chem1998，37，： | 1 |
| 8 | Electricity Consumption Characteristics in Shopping Malls in Subtropical Climates显示文摘 | Joseph C Lam Danny H W Li | 2003 | Energy Conversion & Management2003，，13： | 1 |
| 9 | Genetic programming for analysis and real-time prediction of coastal blooms显示文摘 | Muttil Nitin Lee Joseph H W | 2005 | Ecological Modelling2005，189，34： | 1 |
| 10 | Correlation between global solar radiation and its direct and diffuse components显示文摘 | Joseph C Lam Danny H W Li | 1996 | Building and Environment1996，31，： | 1 |
| 11 | Dynamic response of layered structures subject to blast effects of non-nuclear weaponry显示文摘 | JOHN R H DAVID J R | 1987 | Computers and Structures1987，26，12： | 1 |
| 12 | Generalized system for relaxed cocoercive variational inequalities in Hibert spaces 显示文摘 | CHANG S S JOSEPH LEE H W CHAHN C K | 2007 | Appl Math Lett2007，20，： | 1 |
| 13 | A novel introduction system for hydride generation-inductively coupled plasma mass spectrometry: determination of selenium in biological materials显示文摘 | Christoph Moor Joseph W H Lam Ralph E Sturgeon | | 0，，： | 1 |
| 14 | Neural network modeling of coastal algal blooms显示文摘 | JOSEPH H W LEE Y H MIKE D | 2003 | Ecological Modeling2003，159，23： | 1 |
| 15 | Regression analysis of solar radiation and sunshine duration显示文摘 | Joseph C L Danny H W L | 1996 | Architectural Science Review1996，，39： | 1 |
| 16 | The twelve Rs:An overview of capitalization rate derivation显示文摘 | Joseph H Martin Mark W Sussman | 1997 | Chicago The Appraisal Journal1997，65，2： | 1 |
| 17 | Global attractivity and uniformly persistence in Nichson's blowflies显示文摘 | JOSEPH W H YU JIANSHE | 1994 | Differential Equations and Dynamics systems1994，2，1： | 1 |
| 18 | Generalized System for Relaxed Cocoercive Variational Lnequalities in Hilbert Spaces 显示文摘 | Chang S S Joseph Lee H W Chan C K | 2007 | Appl Math Lett2007，20，： | 1 |
| 19 | An analysis of electricity end use in air-conditioned office buildings in Hong Kong显示文摘 | LAM C JOSEPH LI H W DANNY CHEUNG S O | 2003 | Building and Environment2003，38，3： | 1 |
| 20 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
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