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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Intestinal permeability and its association with the patient and disease characteristics in Crohn's disease显示文摘AIM:To assess the intestinal permeability (IP) in patients with Crohn's disease (CD) and study the association of IP with the patient and disease characteristics. METHODS: One hundred and twenty five consecutive patients of CD (Males: 66) were diagnosed on the basis of a combination of standard clinical, endoscopic, imaging and histological features. CD activity index (CDAI) was used to calculate the activity of the disease while the behavior of the disease was assessed by the modified Montreal classification. IP was measured by the ratio of the percentage excretion of ingested doses of lactulose and mannitol in urine (LMR). The upper limit of normality of LMR (0.037) was derived from 22 healthy controls. RESULTS: Thirty six percent of patients with CD had increased IP. There was no significant difference in mannitol excretion (patients vs controls = 12.5% vs 14.2%, P = 0.4652), but lactulose excretion was significantly higher in patients compared to healthy controls (patients vs controls = 0.326% vs 0.293%, P = 0.0391). The mean LMR was also significantly higher in the patients as compared to healthy controls [0.027 (0.0029-0.278) vs 0.0164 (0.0018-0.0548), P = 0.0044]. Male patients had a higher LMR compared to females [0.036 (95% CI 0.029, 0.046) vs 0.022 (95% CI 0.0178, 0.028) (P = 0.0024), though there was no difference in the number of patients with abnormal IP in boththe sexes. Patients with an ileo-colonic disease had a higher LMR than those with only colonic disease [0.045 (95% CI 0.033, 0.06) vs 0.021 (95% CI 0.017, 0.025) (P < 0.001)]. Of patients with ileo-colonic disease, 57.8% had an abnormal IP, compared to 26.7% with colonic and 15.6% with small intestinal disease. Patients with a stricturing disease had significantly higher LMR compared to non-fistulising non-stricturing disease [0.043 (95% CI 0.032, 0.058) vs 0.024 (95% CI 0.019, 0.029) (P = 0.0062)]. There was no correlation of IP with age, disease activity, duration of illness, D-xylose absorption, upper GI involvement, perianal disease, and extra- intestinal manifestations. On multiple regression analysis, male gender and ileo-colonic disease were independent factors associated with increased IP. Gender, location, behavior of the disease and upper GI involvement could explain up to 23% of variability in IP (R2 = 0.23). CONCLUSION: IP was increased in 36% of patients with CD. Male gender and an ileo-colonic disease were the independent factors associated with increased IP. | Jaya Benjamin Govind K Makharia Vineet Ahuja Mani Kalaivan Yogendra K Joshi | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 3 | Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention显示文摘 | Debasis Bagchi Manashi Bagchi Sidney J Stohs Dipak K Das Sidhartha D Ray Charles A Kuszynski Shantaram S Joshi Harry G Pruess | 2000 | Toxicology2000，，2： | 3 |
| 4 | 印度农业推广改革现状:战略重点和政策选择显示文摘独立以来,虽然印度农业推广经历了翻天覆地的变化,但是小农农民和其他弱势群体仍未参与到公共推广体系之中。许多组织性能问题妨碍了公共推广体系的效率和效果。这些问题包括人员的匮乏,较低的合作伙伴关系以及继续自上而下的线性推广方式。本文回顾了印度农业推广改革的现状,并基于比哈尔、喜马偕尔邦、马哈拉施特拉邦和泰米尔纳德邦等4个邦的实地调研,分析并进一步细化了当前的改革进程,在此基础上,提出了促进农业公共推广体系有序发展和运行的优先政策和战略选择。 | Suresh C Babu P K Joshi Claire J.Glendenning Kwadwo Asenso-Okyere Rasheed Sulaiman V 蔡彦虹(翻译) | 2017 | 世界农业2017，，7： | 2 |
| 5 | 基于离散滑模控制的通信网络拥塞控制(英文)显示文摘最近30年来,离散滑模控制(DSMC)被加以研究.在现有离散滑模控制的文献中,不但有完善的理论,并且有应用的实例.计算机通信网络(涵盖有线和无线情形)的发展给控制专家提出了具有挑战性的问题.此类系统的响应很快,因此要求控制器必须能快速反应.同时,此类系统中的数据包和路由采用固有的切换方式.因此,在该网络系统中采用与其固有切换类似的滑动模态控制成为一个有趣的问题.本文应用离散滑模控制方法来解决通信网络的拥塞控制问题.在过去几年中,许多反馈控制方法被用来解决通信网络的许多问题,如流量控制,拥塞控制和功率控制.本文提出了一种新的应用滑动模态控制来实现通信网络拥塞控制的方法.由于计算机通信网络处理的是数字数据且在本质上是离散的,因此其是一类离散时间系统,因而可应用离散滑模控制.在该系统中,比特率保持恒定不变,通过调整缓冲区的长度来控制拥塞.出于模拟与分析的目的,缓冲区的最大长度被设为250bit.本文展示了离散滑模控制能够实现通讯网络不同特性的控制. | Rutvij C Joshi Vishvjit K Thakar | 2012 | 中国科学技术大学学报2012，42，7： | 2 |
| 6 | Intratumoral FOXP3 expression in infiltrating breast carcinoma: Its association with clinicopatholog- ic parameters and angiogenesis 显示文摘 | Gupta S Joshi K Wiq J D | 2007 | Acta Oncol2007，46，6： | 1 |
| 7 | Supplementation with flax oil and vitamin C improves the outcome of attention deficit hyperactivity disorder (ADHD) 显示文摘 | Joshi K Lad S Kale M | 2006 | Prostaglandins Leukot Essent Fatty Acids2006，74，1： | 1 |
| 8 | Xanthanolides from Xanthium indicum显示文摘 | Bohlmann F Singh P Joshi K C | 1982 | Phytochemistry1982，21，6： | 1 |
| 9 | Organization Knowledge Resources显示文摘 | Holsapple C W Joshi K D | 2001 | Decision Support Systems2001，，31： | 1 |
| 10 | Dynamic testing at high strain rates of an ultrafine-grained magnesium alloy processed by ECAP 显示文摘 | Li B Joshi S Azevedoa K | 2009 | Mater Sci Eng A2009，517，2429： | 1 |
| 11 | Present and prospective role of bioenergy in regional energy system显示文摘 | Ramachandra T V Joshi N V Subramanian D K | 2000 | Renewable Sustainable Energy Rev2000，4，4： | 1 |
| 12 | Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase显示文摘 | Witkowski A Berman H A | 2005 | Biochemistry2005，44，10： | 1 |
| 13 | High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-llocus in advanced breast tumors associated with aggressiveness of the tumor显示文摘 | Gupta S Joshi K Wig JD | 2009 | Indian J Cancer2009，46，4： | 1 |
| 14 | Improving Weavability显示文摘 | Behera BK Joshi V K | 2000 | Synthetic Fibres2000，29，3： | 1 |
| 15 | Influence of fatty alcohol antifoam suspen-sions on foam stability显示文摘 | JOSHI K S JEELANIAS A K BLICKENSTORFERBC | 2005 | Coll Surf A:Phys Eng ASpects2005，263，： | 1 |
| 16 | Axial mixing in pipe flows : Turbulent and transition regions 显示文摘 | Ekambara K Joshi J B | 2003 | Chemical Engineering Science2003，58，12： | 1 |
| 17 | Therapeutic efficacies of isoniazid and rifampin encapsulated in lung - specific stealth liposomes against mycobacterium tuberculosis infection induced in mice 显示文摘 | Deol P Khuller G K Joshi K | 1997 | Antimicrob Agents Chemother1997，41，6： | 1 |
| 18 | The determinants of compli- ance with an early intervention program for high-risk babies in India 显示文摘 | de Souza N Sardessai V Joshi K | 2006 | Child Care Health Development2006，32，1： | 1 |
| 19 | Facile synthesis noval fluorine containning pyrazole based thiazole derivatives and evaluation of antimicrobial activity 显示文摘 | Desai N C Joshi K M Rajpara H V | 2012 | Journal of Fluorine Chemistry2012，142，： | 1 |
| 20 | A new norditerpenoid alkaloids from the seeds of Delphinium ajacis 显示文摘 | Khetwal K S Desai H K Joshi B S | 1994 | Heterocycles1994，38，4： | 1 |
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