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| 1 | Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers显示文摘Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and tissues.The sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal muscles.When these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with HF.These detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment modalities.Therefore,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in HF.Finally,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF. | Josip Anđelo Borovac Domenico D'Amario Josko Bozic Duska Glavas | 2020 | World Journal of Cardiology2020，12，8： | 14 |
| 2 | Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease显示文摘BACKGROUND Matrix Gla protein(MGP)is a vitamin K dependent peptide which has an established role in suppression of vascular calcification.Recent studies have pointed to a possible link between immunomodulatory effect of MGP and inflammatory bowel disease(IBD).AIM To compare plasma levels of dephosphorylated and uncarboxylated MGP(dpucMGP)between IBD patients and controls.METHODS This cross-sectional study was conducted on 70 patients with IBD(30 patients with ulcerative colitis and 40 patients with Crohn’s disease)and 60 age and gender matching healthy controls.Plasma dp-ucMGP levels were analyzed from blood samples by CLIA method using IDS-iSYS InaKtif MGP(Immunodiagnostic Systems,Frankfurt,Germany)according to the manufacturer's instructions.fecal calprotectin(FC)levels were determined from stool samples by turbidimetric immunoassay method using Bühlmann fecal calprotectin turbo assay(Bühlmann Laboratories Aktiengesellschaft,Schonenbuch,Switzerland).Other parameters were analyzed according to the standard laboratory procedures.RESULTS Plasma levels of dp-ucMGP were significantly higher in patients with IBD compared to the healthy control group(629.83±124.20 pmol/mL vs 546.7±122.09 pmol/mL,P<0.001),and there was no significant difference between patients with Crohn’s disease and patients with ulcerative colitis(640.02±131.88 pmol/mL vs 616.23±113.92 pmol/mL,P=0.432).Furthermore,a significant positive correlation of plasma dp-ucMGP levels was found with both FC levels(r=0.396,P<0.001)and high sensitivity C-reactive protein(hsCRP)levels(r=0.477,P<0.001).Moreover,in the total study population a significant positive correlation was found between dp-ucMGP with age(r=0.210,P=0.016)and waist circumference(r=0.264,P=0.002).Multiple linear regression analysis showed that dp-ucMGP levels retained significant association with FC(β±SE,0.06±0.02,P=0.003).CONCLUSION Study results support experimental data of MGP immunomodulatory IBD effect and indicate potential involvement in the pathophysiology of the disease,and possibly extraintestinal manifestations. | Darko Brnic Dinko Martinovic Piero Marin Zivkovic Daria Tokic Marino Vilovic Doris Rusic Ivana Tadin Hadjina Christian Libers Sandro Glumac Daniela Supe-Domic Ante Tonkic Josko Bozic | 2020 | World Journal of Gastroenterology2020，26，32： | 5 |
| 3 | 8-isoprostane as Oxidative Stress Marker in Coal Mine Workers显示文摘This study was to investigate whether working in conditions of elevated concentrations of mine gases(CO2,CO,CH4,DMS)and dust may result in oxidative stress.Coal miners(n=94)from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days.8-isoprostane as a biological marker of oxidative stress was | Zlatko Zimet Marjan Bilban Mateja Marc Malovrh Peter Korogec Borut Poljgak Josko Osredkar Mira Silar | 2016 | Biomedical and Environmental Sciences2016，29，8： | 3 |
| 4 | Role of endoscopic ultrasound in anticancer therapy:Current evidence and future perspectives显示文摘The digestive system is one of the most common sites of malignancies in humans.Since gastrointestinal tumors represent a massive global health burden both in terms of morbidity and health care expenditures,scientists continuously develop novel diagnostic and therapeutic methods to ameliorate the detrimental effects of this group of diseases.Apart from the well-established role of the endoscopic ultrasound(EUS)in the diagnostic course of gastrointestinal and hepatobiliary malignancies,we have recently become acquainted with a vast array of its therapeutic possibilities.A multitude of previously established,evidence-based methods that might now be guided by the EUS emerged:Radiofrequency ablation,brachytherapy,fine needle injection,celiac plexus neurolysis,and endoscopic submucosal dissection.In this review we endeavored to provide a comprehensive overview of the role of these methods in different malignancies of the digestive system,primarily in the treatment and symptom control in pancreatic cancer,and additionally in the management of hepatic,gastrointestinal tumors,and pancreatic cysts. | Andre Bratanic Dorotea Bozic Antonio Mestrovic Dinko Martinovic Marko Kumric Tina Ticinovic Kurir Josko Bozic | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 2 |
| 5 | Influence endothelin ETA receptor antagonist - BQ-123 - on changes of endothelin-1 level in plasma of rats with acute vasospasm following subarachnoid hemorrhage 显示文摘 | Josko J Hendryk S Jedrzejowska-Szypula H | 1998 | J Physiol Pharmacol1998，49，3： | 1 |
| 6 | Adoption of New and Really New Products : The Effects of Self-Regulation Systems and Risk Salience 显示文摘 | Herzenstein Michal Posavac S Steven Brakus J Josko | 2007 | Journal of Marketing Research2007，44，5： | 1 |
| 7 | The role of vascular endothelial growth factor in cerebral edema formation显示文摘 | Josko J Knefel K | 2003 | Folia Neuropathol2003，41，3： | 1 |
| 8 | Vascular endothelial growth factor (VEGF) and its effect on angiogenesis显示文摘 | Josko J Gwozdz B Jedrzejowska-Szypulka H | 2000 | Med Sci Monit2000，6，5： | 1 |
| 9 | The neuroprotective function of vascular endothelial growth factor (VEGF) 显示文摘 | Gora-Kupilas K Josko J | 2005 | Folia Neuropathol2005，43，1： | 1 |
| 10 | The neuroprotective function of vascular endothelial growth factor (VEGF) 显示文摘 | Gora-KupilasK Josko J | 2005 | Folia Neuropathol2005，43，1： | 1 |
| 11 | The neuroprotective function of vascular endothelial growth factor (VEGF)显示文摘 | Gora-Kupilas K Josko J | 2005 | Folia Neuropathol2005，43，1： | 1 |
| 12 | Bond characteristics of carbon,alkali resistant glass and aramid textiles in mortar显示文摘 | Shilang Xu Markus Krüger Hans-W Reinhardt Josko Ozbolt | 2004 | Journal of materials in civil engineering2004，16，4： | 1 |
| 13 | Adaptive Kalman Filter- Based Load Torque Compensator for Improved SI Engine I- dle Speed Control 显示文摘 | Danijel P Josko D Senior Ilya K | 2009 | IEEE Transactions on Control Sys- tems Technology2009，，： | 1 |
| 14 | Safety and efficacy of dual antiplatelet therapy after percutaneous coronary interventions in patients with end-stage liver disease显示文摘The prevalence of coronary artery disease(CAD)increases in patients with endstage liver disease,with part of them receiving the percutaneous coronary intervention(PCI)as a treatment option.Dual antiplatelet therapy(DAPT),a standard of care after PCI,could result in catastrophic consequences in this population.Before PCI and the start of DAPT,it is recommended to assess patient bleeding risk.Based on novel findings,liver cirrhosis does not necessarily lead to a significant increase in bleeding complications.Furthermore,conventional methods,such as the international normalized ratio,might not be appropriate in assessing individual bleeding risk.The highest bleeding risk among cirrhotic patients has a subgroup with severe thrombocytopenia(<50×10^(9)/L)and elevated portal pressure.Therefore,every effort should be made to maintain thrombocyte count above>50×10^(9)/L and prevent variceal bleeding.There is no solid evidence for DAPT in patients with cirrhosis.However,randomized trials investigating short(one month)DAPT duration after PCI with new drug-eluting stents(DES)in a high bleeding risk patient population can be implemented in patients with cirrhosis.Based on retrospective studies(with older stents and protocols),PCI and DAPT appear to be safe but with a higher risk of bleeding complications with longer DAPT usage.Finally,novel methods in assessing CAD severity should be performed to avoid unnecessary PCI and potential risks associated with DAPT.When indicated,PCI should be performed over radial artery using contemporary DES.Complementary medical therapy,such as proton pump inhibitors and beta-blockers,should be prescribed for lower bleeding risk patients.Novel approaches,such as thromboelastography and“preventive”upper endoscopies in PCI circumstances,warn clinical confirmation. | Zvonimir Ostojic Ana Ostojic Josko Bulum Anna Mrzljak | 2021 | World Journal of Cardiology2021，13，11： | 1 |
| 15 | Vascular endothelial growth factor (VEGF) and its effect on angiogenesis显示文摘 | Josko J Gwozdz B Jedrzejowska-Szypulka H | 2000 | Med Sci Monit2000，6，5： | 1 |
| 16 | Sustained loading strength of concrete modelled by creep-cracking interaction显示文摘 | Josko Ozbolt Hans-Wolf Reinhardt | 2001 | Otto-Graf-Journal2001，12，： | 1 |
| 17 | The neuroprotective function of vascular endothelial growth factor (VEGF)显示文摘 | Gora-Kupilas K Josko J | 2005 | Folia Neuropathol2005，43，1： | 1 |
| 18 | Vascular endothelial growth factor(VEGF) and its effect on angiogenesis显示文摘 | Josko J Gwozdz B Jedrzejowska-Szypulka H | 2000 | Med Sci Monit2000，6，5： | 1 |
| 19 | Performance limitations in underwater acoustic telemetry显示文摘 | Josko A C | 1990 | IEEE Journal of Oceanic Engineering1990，15，3： | 1 |
| 20 | Sustained loading strength of concrete modeled by creep-cracking interaction 显示文摘 | Josko Ož bolt Hans-Wolf Reinhardt | 2001 | Otto-Graf-Journal2001，12，： | 1 |
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