|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 2 | Soil boron fertilization:The role of nutrient sources and rootstocks in citrus production显示文摘Boron(B) is a key element for citrus production, especially in tropical regions, where the nutrient availability is commonly low in the soil. In addition, information about doses, fertilizer sources, methods of application, and particularly, differential nutrient demand of scion/rootstock combinations are required for efficient fertilization of commercial groves. In a non-irrigated sweet orange orchard(cv. Natal), grafted onto Rangpur lime, Swingle citrumelo or Sunki mandarin, we studied the application of two sources of B: boric acid(17% B, soluble in water) and ulexite(12% B, partially soluble in water) at four levels of supply(control without B, and soil application of 2, 4 and 6 kg ha^(-1) yr^(-1) of B). The experiment was carried out for three years(2004-2006). Boron availability in the soil and concentration in the leaves, as well as the fruit yield and quality of trees were evaluated. Soil B extracted with hot water and total leaf B positively correlated with doses of the nutrient applied to the trees. Levels of B in the soil and in the leaves did not vary with fertilizer sources. Fruit yield of trees grafted onto Rangpur lime and Swingle citrumelo was more responsive to B doses than those grafted onto Sunki mandarin. The maximum fruit yield of trees grafted onto Swingle was obtained with 3.2 kg ha^(-1) yr^(-1) of B, and leaf B level of 280 mg kg^(-1) that point out to a highest demand for B when this combination was compared with other rootstocks. Furthermore, fertilization with B did not affect the quality of fruits, but correlated with B and potassium(K) concentrations in the leaves. These results also support that the current recommendations for levels of B in leaves should be revisited. | Dirceu Mattos Jr Franz W R Hippler Rodrigo M Boaretto Eduardo S Stuchi Jose A Quaggio | 2017 | Journal of Integrative Agriculture2017，16，7： | 5 |
| 3 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 4 | 奶牛业中霉菌和霉菌毒素的问题(一)显示文摘霉菌毒素是由真菌(霉菌)产生的毒性次级代谢产物,当动物采食了被污染的饲料,或者接触或吸人霉菌时,可引起不良影响(霉菌中毒),其生物学影响包括肝和肾的中毒、中枢神经系统与雌激素的影响等。只有部分霉菌产生霉菌毒素,称为产毒霉菌。霉菌毒素的化学变化多,这也代表化学家族的多样性——分子量范围约200~500。 | 王银东 L W Whitlow W M Hagler Jr | 2010 | 中国畜牧杂志2010，46，2： | 5 |
| 5 | β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios显示文摘β -defensins 是主人防卫的部件,与抗菌剂和多种的免疫调节的性质。在最后 15 年的研究表明了许多 β 的丰富的表示;在不同种类的出生后的 epididymis 的 -defensins。这些蛋白质的区域特定、房间特定的表示的一个坡度在出生后的 epididymis 的上皮被观察。他们进到他们沿着 epididymis 旅行的精子的钠液体和绑定的分泌物在繁殖特定的任务建议了他们的参与。因此,连续注意被给了各种各样的 β为他们在精子功能和富饶的角色的 -defensins。尽管 β -defensins 大部分依赖于雄激素,在 epididymis 调整他们的表达式和函数的内在的机制很好没被理解。最近的调查指出了到在哪儿的一种新、有趣的情形 β ; -defensins 在 Wolffian 管与一个不同表示模式出现, epididymis 的胚胎的先锋与成年 epididymis 对比,从而有关 β 的多功能的角色重新定义这个概念;在发展中的 epididymis 的 -defensins 。在这评论,我们总结 β 的一些当前的看法;在在 prenatal-to-postnatal 转变期间在发展中的 epididymis 在他们的角色上加亮我们的最近的数据和推测的 epididymis 的 -defensins ,在可以贡献 epididymal 生物学和男富饶的更好的理解的这个研究区域把注意带到许多未答复的问题。 | Camilla M Ribeiro Erick JR Silva Barry T Hinton Maria Christina W Avellar | 2016 | Asian Journal of Andrology2016，18，2： | 4 |
| 6 | Coronary blood flow reserve response to left anterior descending coronary artery stenting and its value in predicting coronary restenosis显示文摘 | Tsutsui J M Mathias W Jr Frimm C C | 2003 | J Am Soc Echocardiogr2003，16，5： | 2 |
| 7 | Effects of teratogenic exposures to Zn2+, Cd2+, Ni2+, Co2+ and Cu2+ on metal- lothionein and metallothionein- mRNA contents of xenopus embryos显示文摘 | Sunderman F W Jr Plownam M C Kroftova O S | 1995 | Pharmacol Toxicol1995，76，3： | 2 |
| 8 | 帕立骨化醇下调心肌肾素血管紧张素和成纤维细胞生长因子的表达,改善尿毒症大鼠的心肌肥厚显示文摘维生素D可能通过抑制心肌肾素血管紧张素系统(renin—angiotensinsystem,RAS)和成纤维细胞生长因子 (fibroblast growth factors, FGFs)改善尿毒症所致的心肌肥厚。在实验性大鼠尿毒症模型中,研究者比较利用维生素D类似物帕立骨化醇和血管紧张素转换酶抑制剂依那普利抑制RAS和FGF受体基因表达和心肌肥厚改善之间的关系。 | Freundlich M Li YC Quiroz Y Bravo Y Seeherunvong W Faul C Weisinger JR Rodriguez-Iturbe B 罗冬梅 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 9 | Galanthamine derivatives for the treatment of Alzheimer’s disease显示文摘 | KOSLEY Jr R W | 1996 | Drugs Fut1996，21，6： | 1 |
| 10 | Control Charts for Monitoring the Mean and Variance of Autocorrelated Processes显示文摘 | LU C W REYNOLDS M R Jr | 1999 | Journal of Quality Technology1999，，31： | 1 |
| 11 | Experiments on a current-toggled plasma-opening switch显示文摘 | Mendel C W Jr Savage M E Zagar D M | 1992 | J Appl Phys1992，71，8： | 1 |
| 12 | Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries 显示文摘 | Biekell W H Wall M J Jr Pepe P E | 1994 | N Engl J Med1994，331，17： | 1 |
| 13 | The relationship between bacte-rial vaginosis and preterm birth : A review 显示文摘 | Chaim W Mazor M Leiberman JR | 1997 | Arch Gynecol Ob-stei1997，259，2： | 1 |
| 14 | Reconnaissance of the July10,2000,Payatas Landfill Failure显示文摘 | Merry S M Jr E K Fritz W U | 2005 | Journal of Perfor-mance of Constructed Facilities ASCE2005，19，2： | 1 |
| 15 | A protective function for interleukin 17A in T cell-mediated intestinal inflammation显示文摘 | O'Connor W Jr Kamanaka M Booth CJ | 2009 | Nat Immunol2009，10，6： | 1 |
| 16 | A simple reversed phase high-performance liquid chromatography method polysorbate 80 quantitation in monoclonal antibody drug products显示文摘 | ADAMO M DICK L W Jr QIU D F | 2010 | J Chromatogr B Analyt Technol Biomed Life Sci2010，878，21： | 1 |
| 17 | Variation in trophie shift for stable isotope ratios of carbon, nitrogen, and sulfur显示文摘 | MCCUTCHAN JR J H LEWIS JR W M KENDALL C | 2003 | Oikos2003，102，2： | 1 |
| 18 | Reproductive performance of different sized wild and pond reared Penaeus paulensis females显示文摘 | Cavalli R O Scardua M P Wasielesky Jr W | 1997 | Jour- nal of the World Aquaculture Society1997，28，3： | 1 |
| 19 | Efficiency and long-term stability of a multilayer-coated,ion-etched blazed holographic grating in the 125 nm~133 nm wavelength region显示文摘 | M P Kowalski T W Barbee Jr | 1995 | Applied Optics1995，34，31： | 1 |
| 20 | High dose intensity pulse interleukin-2 with famotidine in metastatic kidney cancer显示文摘 | Quan W D Jr Quan F M | 2009 | Cancer Biother Radiopharm2009，24，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员