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| 1 | 急性缺血性与出血性卒中危险因素的对比研究显示文摘目的通过对1个大样本的医院脑卒中注册资料的分析,观察各种危险因素在脑卒中患者中的发生率,并对脑梗死与脑出血的危险因素,特别是心脏和动脉病变的因素进行比较。方法研究资料来自瑞士洛桑卒中注册的卒中患者共3901例,其中脑梗死3525例,脑出血376例,均预先对各项临床和辅助资料进行编码,输入计算机数据库。所有病例均进行系统的临床和辅助检查,心脏病变经心电图和超声心动图证实;颈内动脉和椎基底动脉的病变采用彩色超声多普勒、磁共振血管成像或常规脑血管造影确诊。结果高血压在脑出血和脑梗死患者中的发生率分别为53.7%和46.7%,两者相比差异有统计学意义(P<0.01)。高血压是本组脑卒中最突出的危险因素,其后依次是吸烟、轻度颈内动脉狭窄(≤50%)、高胆固醇血症、短暂性脑缺血发作、糖尿病以及心脏缺血。多因素分析研究发现,本组卒中患者无论是男性还是女性,吸烟、高胆固醇血症、短暂性脑缺血发作、心房纤颤、器质性心脏疾病以及动脉病变是脑梗死而非脑出血密切相关的危险因素。易患脑出血的惟一显著相关的危险因素是高血压(OR=0.64,P<0.01);心脏和动脉病变患者更容易发生脑梗死,但是,器质性心脏病和轻度颈内动脉狭窄在全体卒中患者中均特别常见。结论缺血性卒中和出血性卒中的危险因素并不一致,心脏和动脉病变是脑梗死而非脑出血的重要的危险因素,某些危险因素还存在性别差异。 | 刘新峰 徐格林 Guy van Melle Julien Bogousslavsky | 2005 | 中华神经科杂志2005，38，7： | 42 |
| 2 | Ski and SnoN, potent negative regulators of TGF-β signaling显示文摘滑雪和密切相关的 SnoN 被他们在 overexpression 之上转变鸡胚胎成纤维细胞的能力作为 oncogenes 发现。当滑雪和 SnoN 的提高的表情也在许多人的癌症房间和纸巾被报导了时,与他们的 pro-oncogenic 活动一致,新兴的证据也为两个建议一项潜在的 anti-oncogenic 活动。另外,滑雪和 SnoN 在房间区别的规定被含有,特别在肌肉和 neuronal 系。滑雪和 SnoN 的多重细胞的搭挡被识别了以理解位于滑雪和 SnoN 的复杂角色下面的分子的机制。在这评论,我们在滑雪和 SnoN 的生物功能上总结最近的调查结果,他们行动的机制并且他们表示的层次怎么被调整。 | Julien Deheuninck Kunxin Luo | 2009 | Cell Research2009，19，1： | 42 |
| 3 | Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge显示文摘While the incidence of gastric cancer has decreased worldwide in recent decades,the incidence of signetring cell carcinoma(SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer,which can be resected endoscopically in some cases and which has a better outcome than non-SRCC,and advanced gastric cancer,which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However,the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified,as the benefit of perioperative chemotherapy and the value of taxanebased chemotherapy are unclear. In this review we analyze recent data on the epidemiology,oncogenesis,prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer. | Simon Pernot Thibault Voron Geraldine Perkins Christine Lagorce-Pages Anne Berger Julien Taieb | 2015 | World Journal of Gastroenterology2015，21，40： | 30 |
| 4 | Current Trends in Pickering Emulsions: Particle Morphology and Applications显示文摘In recent years,Pickering emulsions and their applications have attracted a great deal of attention due to their special features,which include easy preparation and enhanced stability.In contrast to classical emulsions,in Pickering emulsions,solid microparticles or nanoparticles that localize at the interface between liquids are used as stabilizers,instead of surfactants,to enhance the droplet lifetime.Furthermore,Pickering emulsions show higher stability,lower toxicity,and stimuli-responsiveness,compared with emulsions that are stabilized by surfactants.Therefore,they can be considered attractive components for various uses,such as photocatalysis and the preparation of new materials.Moreover,the nanoparticle morphology strongly influences Pickering emulsion stability as well as the potential utilization of such emulsions.Here,we review recent findings concerning Pickering emulsions,with a particular focus on how the nanoparticles morphology(i.e.,cube,ellipsoid,nanosheet,sphere,cylinder,rod,peanut)influences the type and stability of such emulsions,and their current applications in different fields such as antibacterial activity,protein recognition,catalysis,photocatalysis,and water purification. | Danae Gonzalez Ortiz Celine Pochat-Bohatier Julien Cambedouzou Mikhael Bechelany Philippe Miele | 2020 | Engineering2020，6，4： | 22 |
| 5 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 6 | Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica显示文摘Aquaporin-4 (AQP4 ) 是在整个中央神经系统在星形细胞,以及在肾,肺,胃和骨胳的肌肉表示的水选择的 transporter。二 AQP4 isoforms 由其他的 spicing, M1 和 M23 AQP4 生产了,形式 heterotetramers 在称为粒子(OAP ) 的直角的数组的超分子的结构集合在房间血浆膜。AQP4 空的老鼠的显型分析在大脑和针的绳索水显示 AQP4 的参与平衡,星形细胞迁居,神经信号 transduction 和 neuroinflammation。AQP4 空的老鼠表明减少的大脑在细胞毒素的服的浮肿,但是增加的大脑在 vasogenic 浮肿和脑水肿胀大胀大。AQP4 缺乏也增加抓住持续时间,损害 glial 结疤,并且减少自体免疫的 neuroinflammation 的严厉。每这些显型根据在 AQP4 缺乏的减少的星形细胞水渗透是多半可解释的。AQP4 也涉及 neuroinflammatory demyelinating 疾病 neuromyelitis optica (NMO ) ,在指向 AQP4 的自身抗体(NMO-IgG ) 生产星形细胞损坏和发炎的地方。管理 NMO-IgG 和人由 intracerebral 注射补充的老鼠与 neuroinflammation, demyelination, perivascular 补充免职和 glial fibrillary 的损失开发典型 NMO 损害酸的蛋白质和 AQP4 immunoreactivity。我们的调查结果建议基于 AQP4 的治疗学的潜在的实用程序包括为大脑胀大,损害和癫痫的治疗的 AQP4 水运输功能的小分子的调节的人,以及小分子或对为 NMO 的治疗的 AQP4 有约束力的 NMO-IgG 的 monoclonal 抗体 blockers。 | Alan S VERKMAN Julien RATELADE Andrea ROSSI Hua ZHANG Lukmanee TRADTRANTIP | 2011 | Acta Pharmacologica Sinica2011，32，6： | 17 |
| 7 | 不同茶树品种中黄酮苷含量的测定显示文摘本研究采用液相质谱技术分离、鉴定了茶叶中的12种黄酮苷类化合物,包括1种芹菜素苷、2种杨梅素苷、5种槲皮素苷和4种山奈酚苷。结合标准品及高效液相色谱系统,测定了8种不同茶树品种中黄酮苷类化合物的含量。结果显示,不同茶树品种中黄酮苷含量分布广泛,以槲皮苷为主。紫芽品种中12种黄酮苷含量最高,达6.12 mg/g;福建水仙品种中含量最低,仅2.31 mg/g,茶树品种间存在显著性差异(P<0.05)。 | 吴春燕 须海荣 Julien Héritier Wilfried Andlauer | 2012 | 茶叶科学2012，32，2： | 16 |
| 8 | Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones显示文摘According to epidemiological studies,twice as many women as men are affected by irritable bowel syndrome(IBS)in western countries,suggesting a role for sex hormones in IBS pathophysiology.Despite growing evidence about the implications of sex hormones in IBS symptom modulation,data on mechanisms by which they influence disease development are sparse.This review aims to determine the state of knowledge about the role of sex hormones in sensorimotor dysfunctions and to address the possible interplay of sex hormones with common risk factors associated with IBS.The scientific bibliography was searched using the following keywords:irritable bowel syndrome,sex,gender,ovarian hormone,estradiol,progesterone,testosterone,symptoms,pain,sensitivity,motility,permeability,stress,immune system,brain activity,spinal,supraspinal,imaging.Ovarian hormones variations along themenstrual cycle affect sensorimotor gastrointestinal function in both healthy and IBS populations.They can modulate pain processing by interacting with neuromodulator systems and the emotional system responsible for visceral pain perception.These hormones can also modulate the susceptibility to stress,which is a pivotal factor in IBS occurrence and symptom severity.For instance,estrogen-dependent hyper-responsiveness to stress can promote immune activation or impairments of gut barrier function.In conclusion,whereas it is important to keep in mind that ovarian hormones cannot be considered as a causal factor of IBS,they arguably modulate IBS onset and symptomatology.However,our understanding of the underlying mechanisms remains limited and studies assessing the link between IBS symptoms and ovarian hormone levels are needed to improve our knowledge of the disease evolution with regard to gender.Further studies assessing the role of male hormones are also needed to understand fully the role of sex hormones in IBS.Finally,investigation of brain-gut interactions is critical to decipher how stress,ovarian hormones,and female brain processing of pain can translate into gut dysfunctions. | Mathieu Meleine Julien Matricon | 2014 | World Journal of Gastroenterology2014，20，22： | 14 |
| 9 | 新型短程硝化反硝化工艺处理高浓度氨氮废水显示文摘研发了一种新型短程硝化反硝化工艺——ANITATMShunt,它通过特殊的自控系统来控制N2O的释放。采用500 L的SBR中试装置处理消化污泥脱水上清液,经过18个月的稳定运行表明:通过短程硝化反硝化途径可以实现90%的脱氮率,并且释放的N2O不足总脱氮量的0.7%。将通过pH值、温度和在线监测的NO-2-N浓度实时计算的亚硝酸浓度与亚硝酸浓度设定值进行比对,以便对曝气过程进行调控,从而抑制了N2O的释放并实现了对SBR短程硝化反硝化工艺的自动控制。同时证实了在低溶解氧条件下,由氨氧化菌(AOB)在短程硝化反硝化过程中产生的N2O并非与高亚硝酸盐浓度有直接关系,而是与游离亚硝酸浓度有关。 | 宫曼丽 刘洋 赵欣 陈晓华 Romain Lemaire Julien Chauzy | 2013 | 中国给水排水2013，29，11： | 11 |
| 10 | Selective laser melting(SLM)of CX stainless steel:Theoretical calculation,process optimization and strengthening mechanism显示文摘In the present work,selective laser melting(SLM)technology was utilized for manufacturing CX stainless steel samples under a series of laser parameters.The effect of laser linear energy density on the microstructure characteristics,phase distribution,crystallographic orientation and mechanical properties of these CX stainless steel samples were investigated theoretically and experimentally via scanning electron microscope(SEM),X-ray diffraction(XRD),electron backscatter diffraction(EBSD)and transmission electron microscope(TEM).Based on the systematic study,the SLM CX stainless steel sample with best surface roughness(Ra=4.05±1.8μm)and relative density(Rd=99.72%±0.22%)under the optimal linear density(η=245 J/m)can be obtained.SLM CX stainless steel was primarily constituted by a large number of fine martensite(α’phase)structures(i.e.,cell structures,cellular dendrites and blocky grains)and a small quantity of austenite(γphase)structures.The pre ferred crystallographic orientation(i.e.,<111>direction)can be determined in the XZ plane of the SLM CX sample.Furthermore,under the optimal linear energy density,the good combinations with the highest ultimate tensile strength(UTS=1068.0%±5.9%)and the best total elongation(TE=15.70%±0.26%)of the SLM CX sample can be attained.Dislocation strengthening dominates the strengthening mechanism of the SLM CX sample in as-built state. | Dongdong Dong Cheng Chang Hao Wang Xingchen Yan Wenyou Ma Min Liu Sihao Deng Julien Gardan Rodolphe Bolot Hanlin Liao | 2021 | Journal of Materials Science & Technology2021，，14： | 11 |
| 11 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 12 | 激光选区熔化成形nano-WC/CX钢微观组织及机械性能初探显示文摘为进一步提高激光3D打印CX不锈钢材料的机械性能,首先使用静电自组装方法对CX钢粉末表面进行了纳米WC粉末的修饰,之后对经纳米WC表面修饰的CX钢粉末进行了激光选区熔化成形(Selective laser melting,SLM),对比了添加体积分数5%的WC前后的SLM CX钢试样的机械性能.结合金相显微镜(OM)、扫描电子显微镜(SEM)、能谱分析(EDS)及电子背散射衍射(EBSD)等材料表征手段,对SLM nano-WC/CX钢试样的微观组织结构、元素分布及相应机械性能进行了对比分析.结果表明:体积分数为5%的纳米WC的加入,对SLM nano-WC/CX钢的硬度提升有所帮助,使硬度值从352±8.2 HV_(0.2)提升至361±23.5 HV_(0.2);尽管纳米WC的加入使SLM nano-WC/CX钢的延伸率有所降低,但其最大拉伸强度则由1091.4±6.12 MPa提升到了1109.7±15.26 MPa.总之,初步探索可以发现,通过静电自组装方法,在CX钢粉末表面添加适量的纳米WC颗粒可以有效改善SLM CX钢的最终机械性能. | 常成 闫星辰 GARDAN Julien DENG Sihao BOLOT Rodolphe LIAO Hanlin | 2021 | 材料研究与应用2021，15，4： | 10 |
| 13 | 中国人口红利结束了吗?显示文摘经过30多年的快速发展,中国的经济增长势头在最近几年开始放缓。尽管无限供给的劳动力已经不再是我国经济增长的主要驱动力,但中国的刘易斯拐点并没有真正到来。通过对现有研究中多种人口红利定义进行梳理、融合,重新界定了'人口红利'的概念。结合数据分析了中国人口红利的现状,抽象成人口红利变动趋势的概念模型,并用该模型预测了中国人口红利的结束期。中国人口红利的存量仍然巨大,但存量的下降趋势明显,中国人口红利的机会窗口将于2035年关闭。 | 杨帆 黄少安 Julien Picault | 2017 | 山东社会科学2017，，4： | 10 |
| 14 | 湖南烟溪病圃稻瘟病菌的有性态及微卫星标记的遗传多样性分析显示文摘用 2对稻瘟病菌的两性能育菌株 (交配型 1.1和交配型 1.2 )测定了来自湖南烟溪病圃上的 4年 12 4个稻瘟病菌株的交配型 ,用微卫星分子标记分析其中 10 5个菌株的遗传多样性及其亲缘关系。12 4个菌株中 ,2 8个为交配型 1.1,39个为交配型 1.2 ,5 7个不育 ,分别占供试菌株的 2 2 .5 8%、31.4 5 %和 4 5 .97% ;在 0 .6 7相似性的基础上 ,7对微卫星引物扩增出的标记可将 10 5个菌株区分为 6个系谱群。 | 沈瑛 Julien FROUIN 何月秋 Claudia KAYE 肖放 Jean Loup NOTTEGHEM 刘二 Didier THARREAU | 2004 | 中国水稻科学2004，18，3： | 10 |
| 15 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 8 |
| 16 | Chloramination of wastewater effluent: Toxicity and formation of disinfection byproducts显示文摘The reclamation and disinfection of waters impacted by human activities(e.g., wastewater effluent discharges) are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts(N-DBPs). Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-DBPs. Individual toxicity assays have been performed on many DBPs, but few studies have been conducted with complex mixtures such as wastewater effluents. In this work, we compared the cytotoxicity and genotoxicity of wastewater effluent organic matter(Ef OM) before and after chloramination. The toxicity of chloraminated Ef OM was significantly higher than the toxicity of raw Ef OM, and the more hydrophobic fraction(HPO)isolated on XAD-8 resin was more toxic than the fraction isolated on XAD-4 resin.More DBPs were also isolated on the XAD-8 resin. N-DBPs(i.e., haloacetonitriles or haloacetamides) were responsible for the majority of the cytotoxicity estimated from DBP concentrations measured in the XAD-8 and XAD-4 fractions(99.4% and 78.5%, respectively).Measured DBPs accounted for minor proportions of total brominated and chlorinated products, which means that many unknown halogenated compounds were formed and can be responsible for a significant part of the toxicity. Other non-halogenated byproducts(e.g.,nitrosamines) may contribute to the toxicity of chloraminated effluents as well. | Julien Le Roux Michael J.Plewa Elizabeth D.Wagner Maolida Nihemaiti Azra Dad Jean-Philippe Croué | 2017 | Journal of Environmental Sciences2017，29，8： | 8 |
| 17 | Water Resource Monitoring Exploiting Sentinel-2 Satellite and Sentinel-2 Satellite Like Time Series;Application in Yangtze River Water Bodies显示文摘As part of the Dragon 4 project,the water extents of Wuchang and Shengjin lakes have been extracted from Sentinel-2 time series,using all exploitable images since the beginning of the acquisitions in 2015.The aim of the study is to assess the capability of the Sentinel-2 constellation and Landsat 8 over the Anhui region,especially the high temporal resolution.A total of 32 dates have been used and 10 Landsat 8 images(Libra)have been added to try to reduce the temporal gaps in the Sentinel-2 acquisitions caused by cloudy conditions.Extractions were done using a SERTIT-ICube automatized routine based on a supervised Maximum Likelihood Classification.These extractions allow to recreate the dynamic of the two lakes and show the drought and wet periods.During the 3 years interval,the surface peaks in July 2016 for both lakes.The lowest level appears at two different dates for each lake;in January 2018 for Wuchang,in February 2017 for Shengjin.Wuchang Lake surface area appears to be more variable than Shengjin Lake,with many local maximum and minimum between the end of 2017 and April 2018.In the case of Wuchang Lake,floating vegetation is a problem for automatic water surface area extraction.The lake is covered by vegetation during long periods of time and the water below can’t be detected by automatic radiometric means.Nevertheless,Sentinel-2 stays a pertinent and powerful tool for hydrological monitoring of lakes confirming the expectation from the remote sensing wetland community before launch.The presence of NIR and SWIR bands induces a strong discrimination between water and other classes,and the systematic acquisitions create dense time series,making analysis more consistent.It makes possible to sensor events occurring over short periods of time.Thanks to this a link can be done between endangered bird species,such as the Siberian Crane and the Lesser White-Fronted Goose and periodically flooded areas.These midterm results illustrated the pertinence and powerful of multi-source optical satellite data for environmental analysis. | Julien BRIANT Huber CLAIRE Studer MATHIAS Lei CAO Kunpeng YI Yésou HERV | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 8 |
| 18 | Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma显示文摘This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative surgery.The potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial. | Nicolas Williet Olivier Dubreuil Tarek Boussaha Isabelle Trouilloud Bruno Landi Martin Housset Muriel Botti Philippe Rougier Jacques Belghiti Julien Taieb | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 19 | How to assess the efficacy or failure of targeted therapy:deciding when to stop sorafenib in hepatocellular carcinoma显示文摘Sorafenib is thus far the only systemic treatment for hepatocellular carcinoma(HCC) based on the results of two randomized controlled trials performed in Western and in Eastern countries, despite a poor response rate(from 2% to 3.3%) following conventional evaluation criteria. It is now recognized that the criteria(European Association of the Study of the Liver criteria, modified response evaluation criteria in solid tumors) based on contrast enhanced techniques(computed tomography scan, magnetic resonance imaging) aimed to assess the evolution of the viable part of the tumor(hypervascularized on arterial phase) are of major interest to determine the efficacy of sorafenib and of most antiangiogenic drugs in patients with HCC. The role of alphafetoprotein serum levels remains unclear. In 2016, in accordance with the SHARP and the Asia-Pacific trials, sorafenib must be stopped when tolerance is poor despite dose adaptation or in cases of radiological and symptomatic progression. This approach will be different in cases of available second-line therapy trials. Some recent data(in renal cell carcinoma) revealed that despite progression in patients who received sorafenib, this drug can still decrease tumor progression compared to drug cessation. Then, before deciding to continue sorafenib post-progression or shift to another drug, knowing other parameters of post-progression survival(Child-Pugh class, Barcelona Clinic Liver Cancer, alphafetoprotein, post-progression patterns in particular, the development of extrahepatic metastases and of portal vein thrombosis) will be of major importance. | Jean-Luc Raoul Xavier Adhoute Marine Gilabert Julien Edeline | 2016 | World Journal of Hepatology2016，8，35： | 8 |
| 20 | Animal personality and the ecological impacts of freshwater non-native species显示文摘 | Tristan JUETTE | 2014 | Current Zoology2014，60，3： | 7 |
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