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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Synthesis of highly ordered carbon molecular sieves via template-mediated structural transformation 显示文摘 | Ryoo R Joo S H Jun S | 1999 | J Phys Chem B1999，103，37： | 1 |
| 3 | 查看详情显示文摘 | Vishwanathan V Jun K W Kim J W Roh H S | | 0，，： | 1 |
| 4 | Synthesis of new, nanoporous carbon with hexagonally ordered mesostructure显示文摘 | Jun S Joo S H Ryoo R | 2000 | J Am Chem Soc2000，122，10： | 1 |
| 5 | Selection of microalgae for lipid production under high levels carbon dioxide 显示文摘 | YOO C JUN S Y LEE J Y AHN C Y OH H M | 2010 | Bioresoure Technology2010，101，1： | 1 |
| 6 | Synthesis of Ordered Meso- porous Carbon Molecular Sieves CMK-1 显示文摘 | Joo S H Jun S Ryoo R | 2001 | Mi- croporous Mesoporous Mater2001，4445，： | 1 |
| 7 | ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery显示文摘 | JUNG C H JUN C B RO S H | 2009 | Molecular Biology of the Cell2009，20，7： | 1 |
| 8 | Hemostatic suturing technique for uterine bleeding during cesarean delivery显示文摘 | Cho J H Jun H S Lee C N | | 0，，01： | 1 |
| 9 | Cooperative Norms,Structural Mechanisms and Supplier Performance:Empirical Evidence from Chinese Manufacturers显示文摘 | Cai S H Yang Z L Jun M | 2011 | Journal of Purchasing&Supply Management2011，17，1： | 1 |
| 10 | Evolution of Precipitates in the Nb-Ti-V Microalloyed HSLA Steels During Reheating 显示文摘 | Hong S G Jun H J Kang K B | 2003 | Seripta Materialia2003，48，： | 1 |
| 11 | Defect structure induced by iron injection in WC-Co显示文摘 | BAIK S I CHOI E G JUN J H ICIM Y W | 2008 | Scripta Materialia2008，58，： | 1 |
| 12 | A new curve- based approach to polyhedral machining 显示文摘 | Jun C S Kim D S Park S H | 2002 | Computer - Aided Design2002，34，5： | 1 |
| 13 | NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter显示文摘 | JUN C H LEE T S SOHN U D | 2003 | Auton Autacoid Pharmacol2003，23，3： | 1 |
| 14 | Cyclophosphamide inhibits the development of diabetes in the diabetes-prone BB rat 显示文摘 | Sobel D O Ahvazi B Jun H S | 2000 | Diabetologia2000，43，8： | 1 |
| 15 | Polymerization of lactides and lactones by Metal-Free initiators显示文摘 | Li H Jun W Brunel S | 2005 | Ind Eng Chem Res2005，44，： | 1 |
| 16 | Damping capacity in Fe -Mn binary alloys显示文摘 | Lee Y K Jun J H Choi C S | 1997 | ISIJ International1997，37，10： | 1 |
| 17 | A kinetic analysis of the thermal-oxidative decomposition of expandable polystyrene 显示文摘 | JUN H C OH S C | 2006 | Korean J Chem Eng2006，23，5： | 1 |
| 18 | A simple and fast algorithm for K-mednids clus- tering 显示文摘 | PARK H S JUN C H | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 19 | Liquidity and stock returns in emerging equity markets显示文摘 | JUN S G MARATHE A SHAWKY H A | | 0，，01： | 1 |
| 20 | 2-Arylbenzoxasoles from phenolic Schiff's bases by thianthrene cation radical显示文摘 | PARK K H JUN K SHIN S R | | 0，，49： | 1 |
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