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| 1 | Histone modifications dictate specific biological readouts显示文摘The basic unit of chromatin is the nucleosomal core particle, containing 147 bp of DNA that wraps twice around an octamer of core histones.The core histones bear a highly dynamic N-terminal amino acid tail around 20?35 residues in length and rich in basic amino acids.These tails extending from the surface of nucleosome play an important role in folding of nucleosomal arrays into higher order chromatin structure, which plays an important role in eukaryotic gene regulation.The amino terminal tails protruding from the nuclesomes get modified by the addition of small groups such as methyl, acetyl and phosphoryl groups.In this review, we focus on these complex modification patterns and their biological functions.Moreover, these modifications seem to be part of a complex scheme where distinct histone modifications act in a sequential manner or in combination to form a'histone code'read by other proteins to control the structure and/or function of the chromatin fiber.Errors in this histone code may be involved in many human diseases especially cancer, the nature of which could be therapeutically exploited.Increasing evidence suggests that many proteins bear multiple, distinct modifications, and the ability of one modification to antagonize or synergize the deposition of another can have significant biological consequences. | Anjana Munshi Gowhar Shafi Nishat Aliya Akka Jyothy | 2009 | Journal of Genetics and Genomics2009，36，2： | 10 |
| 2 | Genetics of Nonalcoholic Fatty Liver Disease:An Overview显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease in the world today.Its incidence in adults and children is rising rapidly due to the ongoing epidemics of obesity and type 2 diabetes.Hence,it has become a global public health issue.Environmental factors have been found to play a major role in the etiology of NAFLD,especially for genetically susceptible populations. Among these,one of the most important factors is junk food,especially the typical 'Western-style' diet rich in simple carbohydrates, saturated fat,and highly processed food materials.Genetic predisposition to NAFLD does occur;however,a precise definition of genetic factors responsible for NAFLD is still lacking.Specific variants of different genes have been shown to present a risk for NAFLD.Genetic studies might be helpful in the management of the disease by developing novel treatment strategies based on individual's genotype. | Jharna Puppala Siva Prasad Siddapuram Jyothy Akka Anjana Munshi | 2013 | Journal of Genetics and Genomics2013，40，1： | 5 |
| 3 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 4 | Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer显示文摘AIM: To investigate the role of endothelial nitric oxide synthase-786 T > C promoter polymorphism in the etiology of gastric cancer(GC). METHODS: A total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori(H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DNA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software. RESULTS: There was a significant difference in the distribution of C allele(C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype(T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects(P < 0.05). Patients with smoking and alcoholism developed cancer even in heterozygous T/C condition(smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. No significant difference was noticed between cases and controls with regard to consanguinity(P = 0.473).CONCLUSION: The Present data suggest that eN OS-786 C/C genotype and C allele may be considered as potential risk factors in patients with GC. | Devulapalli Krishnaveni Bhayal Amar Chand Porika Shravan Kumar Malladi Uma Devi Macherla Ramanna Akka Jyothy Nallari Pratibha N Balakrishna Ananthapur Venkateshwari | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 2 |
| 5 | Antibacterial activity of medicinal plant Cyclea peltata (Lam) Hooks & Thoms显示文摘 | Jyothi Abraham T. Dennis Thomas | 2012 | Asian Pacific Journal of Tropical Disease2012，，： | 2 |
| 6 | Diagnosis of neurocysticercosis among patients with seizures in northern coastal districts of Andhra Pradesh, India显示文摘Objective: To report cases of neurocysticercosis(NCC) from three neighboring districts of Andhra Pradesh state in India where NCC burden was never explored before.Methods: A total of 160 patients presenting with recent onset seizures were recruited from neurology, general medicine, and pediatric outpatient clinics of a local major tertiary care teaching hospital serving above districts during the period 2011–2014. Brain imaging was performed in all the above cases. A commercial immunoglobulin G-ELISA kit(sensitivity = 85%; specificity = 94%) was employed for the serological diagnosis of NCC.Results: The recruited patients presented with generalized, simple partial, and complex partial seizures(55%, 31.25% and 13.75% respectively). NCC was diagnosed in 44 of160(27.5%) seizure cases based on imaging characteristics, and a positive serum antibody ELISA. No association was detected between seropositivity with the number and location of the lesion(s) in the brain.Conclusions: The possible potentiality of NCC could be identified as an underlying cause of the recent onset of seizures in this region as explored in the present study. It is recommended that NCC should be suspected as one of the major differential in every recent onset seizure with or without a radio imaging supportive diagnosis, especially in areas endemic for taeniasis/cysticercosis. | Bala Chandra Sekhar Pappala Jyothi Padmaja Indugula Sateesh Kumar Talabhatula Ramalakshmi Suryakarani Kolli Arpit Kumar Shrivastava Priyadarshi Soumyaranjan Sahu | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，11： | 2 |
| 7 | An unusual site of epidermoid cyst 显示文摘 | Jyothi SR Mohan M Sathyaki DC | 2013 | J Ewlut Med Dent Sci2013，2，： | 1 |
| 8 | Effect of Spirulina maxima on the halo- peridol induced tardive dyskinesia and oxidative stress in rats显示文摘 | Thaakur S R Jyothi B | 2007 | Neural Transm2007，114，9： | 1 |
| 9 | Anti- microbial resistance pro- file of Citrobacter species in a tertiary care hospital of southern India 显示文摘 | Metri BC Jyothi P Peerapur BV | 2011 | Indian J Med Sci2011，65，10： | 1 |
| 10 | Solvent extraction behaviour of lanthanum(Ⅲ),cenum(Ⅲ), europium(Ⅲ), thorium(Ⅳ) and uranium(Ⅵ) with 3-phenyl-benzoyl-5-isoxazolone 显示文摘 | JYOTHI A RAO G N | 1990 | Talanta1990，37，4： | 1 |
| 11 | Seoective o-methylation of catechol using dimethyo carbonate over calcined Mg-Al Hydrotalcites显示文摘 | T M Jyothi T paja M B talawar | 2001 | Applied Catalysis A:General2001，，211： | 1 |
| 12 | Parental age and the origin of ertra chromosome 21 in Down syndrome 显示文摘 | Jyothy A Kumar KS Mallikarjuna GN | 2001 | J Hum Genet2001，46，6： | 1 |
| 13 | Bacteriological profile of neonatal septicemia and antibiotic susceptibility pattern of the isolates显示文摘 | Jyothi P Basavaraj MC Basavaraj PV | 2013 | J Nat Sci Biol Med2013，4，2： | 1 |
| 14 | Correlation between colposcopy,cytolo- gy and histopathology in high-risk patients for cervical cancer in perim- enopausal women in himachal pradesh, India 显示文摘 | Jyothi R Gupta P Rao R | 2013 | Journal of South Asia Federation of Menopause Societies2013，1，1： | 1 |
| 15 | Reeyelable heterogeneous copper oxide on alumina catalyzed coupling of phenols and alco- hols with aryl halides under ligand-free conditions 显示文摘 | Kokkirala Swapna Sabbavarapu Narayana Murthy Moehar- la Tarani Jyothi | 2011 | Org Biomol Chem2011，9，： | 1 |
| 16 | The exonomics of biodiversity conservation:a study of a coffee growing region in the Western Ghats of India 显示文摘 | K N Ninan Jyothis Sathyapalan | 2005 | Ecological Econ2005，55，1： | 1 |
| 17 | Formation of anisaldehyde via hydroxymethylation of anisole over SnO2 - CeO2 catalysts 显示文摘 | Jyothi T M Talawar M B Rao B S | 2000 | Catalysis Letters2000，64，： | 1 |
| 18 | Cross-layer modeling and simulation of circuit reliability显示文摘 | Yu Cao Jyothi Velamala Ketul Sutaria | 2014 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems2014，33，1： | 1 |
| 19 | A study of surface roughness in drilling using mathematical analysis and neural networks 显示文摘 | Sanjay C Jyothi C | 2006 | Int J Adv Manuf Teehnol2006，29，： | 1 |
| 20 | Solvent extraction behaviour of lanthanum ( Ⅲ ) , cerium ( Ⅲ ) , europium ( Ⅲ ) , thorium ( Ⅳ ) and uranium ( Ⅵ ) with 3-phenyl-benzoyl-5-isoxazolone 显示文摘 | Jyothi A Rao G N | 1990 | Talanta1990，37，4： | 1 |
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