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| 1 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 2 | Targeted therapy of gastrointestinal stromal tumours显示文摘Gastrointestinal stromal tumours(GISTs) are mesen-chymal neoplasms originating in the gastrointestinal tract, usually in the stomach or the small intestine, and rarely elsewhere in the abdomen. The malignant potential of GISTs is variable ranging from small lesions with a benign behaviour to fatal sarcomas. The majo-rity of the tumours stain positively for the CD-117(KIT) and discovered on GIST-1(DOG-1 or anoctamin 1) expression, and they are characterized by the presence of a driver kinase-activating mutation in either KIT or platelet-derived growth factor receptor α. Although surgery is the primary modality of treatment, almost half of the patients have disease recurrence following surgery, which highlights the need for an effective adjuvant therapy. Traditionally, GISTs are considered chemotherapy and radiotherapy resistant. With the advent of targeted therapy(tyrosine kinase inhibitors), there has been a paradigm shift in the management of GISTs in the last decade. We present a comprehensive review of targeted therapy in the management of GISTs. | Ashish Jakhetiya Pankaj Kumar Garg Gaurav Prakash Jyoti Sharma Rambha Pandey Durgatosh Pandey | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 14 |
| 3 | Preoperative therapy in locally advanced esophageal cancer显示文摘Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer. | Pankaj Kumar Garg Jyoti Sharma Ashish Jakhetiya Aakanksha Goel Manish Kumar Gaur | 2016 | World Journal of Gastroenterology2016，22，39： | 13 |
| 4 | Laser Direct Metal Deposition Technology and Microstructure and Composition Segregation of Inconel 718 Superalloy显示文摘Multilayer of laser direct metal deposition(DMD)was prepared by depositing a gas atomized pre-alloyed powder with a composition close to Inconel 718 alloy on Inconel 718 high temperature alloy substrate.The effects of the DMD parameters on the build-up rate and the structure of the deposited layer were studied.The laser DMD sample was further processed by a solution treatment.The microstructure and property of the laser DMD zone before and after heat treatment were investigated as well.The results show that the laser parameters of actual laser power of 650 W,scanning speed of 5.8 mm/s,beam diameter of 1 mm,powder feed rate of 6.45 g/min,with a corresponding specific energy of 90-130 J/mm2,can be recommended as optimum parameters for high build-up rate of Inconel 718 alloy.Under the condition of optimized parameters,a directional solidification microstructure was obtained and the average distance between the columnar crystals was 5-10 μm.The microcomposition segregation was found between the columnar crystal trunk and columnar crystal.The elements of Nb,Mo,Ti concentrated in the columnar crystal trunk.After the heat treatment,the segregation was greatly minimized,and the segregation ratios were close to 1.The hardness of the laser deposited layer did not show obvious difference along the height of the layer either for the as-deposited layer or for the heat treated layer.However,the microhardness of the laser DMD zone after heat treatment was obviously higher than that after the as-deposited treatment.During the heat treatment process,some Nb-and Mo-rich phases precipitated and strengthened DMD layer. | ZHANG Qun-li YAO Jian-hua Jyoti Mazurnder | 2011 | Journal of Iron and Steel Research(International)2011，18，4： | 12 |
| 5 | Effects of Tillage Practices and Land Use Management on Soil Aggregates and Soil Organic Carbon in the North Appalachian Region,USA显示文摘Promoting soil carbon sequestration in agricultural land is one of the viable strategies to decelerate the observed climate changes.However,soil physical disturbances have aggravated the soil degradation process by accelerating erosion.Thus,reducing the magnitude and intensity of soil physical disturbance through appropriate farming/agricultural systems is essential to management of soil carbon sink capacity of agricultural lands.Four sites of different land use types/tillage practices,i) nc-till(NT) corn(Zea mays L.)(NTC),ii) conventional till(CT) corn(CTC),iii) pastureland(PL),and iv) native forest(NF),were selected at the North Appalachian Experimental Watershed Station,Ohio,USA to assess the impact of NT farming on soil aggregate indices including water-stable aggregation,mean weight diameter(MWD) and geometric mean diameter(GMD),and soil organic carbon and total nitrogen contents.The NTC plots received cow manure additions(about 15 t ha^(-1)) every other year.The CTC plots involved disking and chisel ploughing and liquid fertilizer application(110 L ha^(-1)).The results showed that both water-stable aggregation and MWD were greater in soil for NTC than for CTC.In the 0-10 cm soil layer,the > 4.75-mm size fraction dominated NTC and was 46%more than that for CTC,whereas the < 0.25-mm size fraction was 380%more for CTC than for NTC.The values of both MWD and GMD in soil for NTC(2.17 mm and 1.19 mm,respectively) were higher than those for CTC(1.47 and 0.72 mm,respectively) in the 0-10 cm soil layer.Macroaggregates contained 6%-42%and 13%-43%higher organic carbon and total nitrogen contents,respectively,than microaggregates in soil for all sites.Macroaggregates in soil for NTC contained 40%more organic carbon and total nitrogen over microaggregates in soil for CTC.Therefore,a higher proportion of microaggregates with lower organic carbon contents created a carbon-depleted environment for CTC.In contrast,soil for NTC had more aggregation and contained higher organic carbon content within water-stable aggregates.The soil organic carbon and total nitrogen stocks(Mg ha^(-1)) among the different sites followed the trend of NF > PL > NTC > CTC,being 35%-46%more for NTC over CTC.The NT practice enhanced soil organic carbon content over the CT practice and thus was an important strategy of carbon sequestration in cropland soils. | Arun Jyoti NATH Rattan LAL | 2017 | Pedosphere2017，27，1： | 11 |
| 6 | Evaluation of remediation process with soapberry derived saponin for removal of heavy metals from contaminated soils in Hai-Pu, Taiwan显示文摘The use of a biodegradable natural plant-based surfactant extracted from soapberry is proposed for the remediation of Ni,Cr and Mn from industrial soil site in Hai-Pu,Taiwan.Batch experiments were performed under variation of fundamental factors(saponin concentration,pH,and incubation time) for metal remediation.Removal of Ni and Mn were increased with increasing saponin concentration(0.015-0.150 g/L),whereas the removal of Cr was increased upto 0.075 g/L saponin.The Ni,Cr and Mn were removed significantly(p ≤ 0.05) at near to the neutral and slightly acidic(pH 5 to 8) conditions.Removal efficiency of Ni(99%) from the soil was found to be greater than that of Cr(73%) or Mn(25%) in the presence of saponin at a concentration of 0.150 g/L at pH 5.The removal percentage increased with incubation time where the removal of Ni was faster than that of Cr and Mn.The result indicates the feasibility of eco-friendly removal of heavy metal(Ni,Cr and Mn) from industrial soil by soil washing process in presence of plant derived saponin. | Jyoti Prakash Maity Yuh Ming Huang Cheng-Wei Fan Chien-Cheng Chen Chun-Yi Li Chun-Mei Hsu Young-Fo Chang Ching-I Wu Chen-Yen Chen Jiin-Shuh Jean | 2013 | Journal of Environmental Sciences2013，25，6： | 11 |
| 7 | Unusual disposition of lateral circumflex femoral artery: Anatomical description and clinical implications显示文摘The anatomical knowledge of arterial variations of lower limb is of utmost significance for the present day surgeons and interventional radiologists for minimizing complications during vascular reconstructive procedures, catheterization procedures and surgical intervention for embolism. Lateral Circumflex Femoral Artery(LCFA) isan important branch of Profunda Femoris artery and precise knowledge of its variations can be of great relevance during surgical and radiological procedures in femoral region. The present study reports a unique case of anomalous route taken by LCFA posterior to femoral nerve associated with a prominent muscular branch from Femoral artery mimicking the course of LCFA. Documentation of such variations is highly significant. It may serve as guideline for surgeons in reducing the incidence of postoperative complications where LCFA is used as a long vascular pedicle in anterolateral perforator thigh flap and in breast reconstruction after mastectomy. Ignorance of such variations can lead to fatal intraoperative haemorrhage and incapacitating sensory and motor deficit due to injury to femoral nerve branches which are closely related to these vessels. | Shivi Goel Jyoti Arora Vandana Mehta Mona Sharma Rajesh Kumar Suri Gayatri Rath | 2015 | World Journal of Clinical Cases2015，3，1： | 11 |
| 8 | 大高良姜的药理学及植物化学研究综述(英文)显示文摘传统医学使用大量具有医用及药用价值的植物治疗疾病,因此是生物活性物质的一个宝库。姜科植物大高良姜通常被用作调经剂、催欲剂、堕胎药、驱风剂、退热剂和抗炎药等,可用于治疗支气管炎、心脏疾病、慢性肠炎、肾结石、糖尿病、风湿病及肾脏疾病。大高良姜含有精油、鞣酸、苯酚、苷类、单萜及糖类等。过去几年,有报道大高良姜各部位提取物中还含有没食子酸、生姜异黄酮、β-谷甾醇、高良姜素、良姜素、花姜酮、山萘素等。本文总结了近年来有关大高良姜的研究中新的植物化学成分及药理学的研究内容。 | Dhirender Kaushik Jyoti Yadav Pawan Kaushik Disha Sacher Ruby Rani | 2011 | 中西医结合学报2011，9，10： | 10 |
| 9 | Plant Small RNAs: Biogenesis, Mode of Action and Their Roles in Abiotic Stresses显示文摘Small RNAs (sRNAs) are 18-30 nt non-coding regulatory elements found in diverse organisms, which were initially identified as small double-stranded RNAs in Caenorhabditis elegans. With the development of new and improved technologies, sRNAs have also been identified and characterized in plant systems. Among them, micro RNAs (miRNAs) and small interfering RNAs (siRNAs) are found to be very important riboregulators in plants. Various types of sRNAs differ in their mode of biogenesis and in their function of gene regulation. sRNAs are involved in gene regulation at both transcriptional and post-transcriptional levels. They are known to regulate growth and development of plants. Furthermore, sRNAs especially plant miRNAs have been found to be involved in various stress responses, such as oxidative, mineral nutrient deficiency, dehydration, and even mechanical stimulus. Therefore, in the present review, we focus on the current understanding of biogenesis and regulatory mechanisms of plant sRNAs and their responses to various abiotic stresses. | Praveen Guleria Monika Mahajan Jyoti Bhardwaj Sudesh Kumar Yadav | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 10 |
| 10 | 先天性白内障手术治疗研究进展显示文摘随着显微手术技术的进步,白内障摘除联合微创前段玻璃体切除及人工晶状体(IOL)植入术已经成为治疗先天性白内障的主要方法。2岁以下儿童一期植入IOL已经成为一种趋势。对眼轴长度、角膜曲率及屈光度变化的准确估计,IOL度数选择的综合考虑,积极规范的弱视训练和长期随访对于获得良好的视觉重建结果尤为重要。本文对这一领域近5年的研究进展进行综述。 | Jyoti Sapkota 刘馨 樊帆 罗怡 | 2016 | 中国眼耳鼻喉科杂志2016，16，4： | 8 |
| 11 | Inflammatory bowel disease requires the interplay between innate and adaptive immune signals显示文摘煽动性的碗疾病(IBD ) 是一种类型 1 个 T 助手房间(Th1 ) 调停了自体免疫的疾病。各种各样的研究表明了环境病原体也在这疾病的开始和前进起一个重要作用。有趣地, IBD 的致病被显示了与氮的氧化物有关(没有) 免除了天生的有免疫力的房间。尽管不被知道对内脏 epithelia 高度有毒,没有生产的规定有很小的信息,在 IBD 的病原学的一个主要问题是 Th1 房间和病原体怎么在 IBD 的正式就职交往。在现在的学习,我们集中于我们显示出的号码的规定巨噬细胞要求两 interferon-gamma (IFN-gamma ) ,这调停了并且为生产的调停 TLR4 的信号没有,它在肠并且随后引起发炎 IBD。因此, IBD 是天生的有免疫力的信号的一致行动的结果,例如到 TLR-4,和适应有免疫力的信号的 LPS 的绑定,例如 Th1 房间生产的 IFN-gamma。 | Dayna Shi Jyoti Das Gobardhan Das | 2006 | Cell Research2006，16，1： | 8 |
| 12 | Antidiabetic activity of methanolic bark extract of Alhizia odoratissima Benth.in alloxan induced diabetic albino mice显示文摘Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P<0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals. | Dinesh Kumar Sunil Kumar Sonia Kohli Renu Arya Jyoti Gupta | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 7 |
| 13 | Influence of heat treatment on the structural and optical properties of SrGd_2O_4:Eu^(3+) phosphor显示文摘Novel red emitting Eu3+ doped SrGd2O4 phosphors were synthesized by homogeneous precipitation method followed by a subsequent combustion process at various temperatures. A systematic study on the consequent structural evolution and optical properties were investigated as a function of various processing temperatures. With the enhancement of processing temperature, SrGd2O4 phosphor showed a gradual transformation from a mixed phase to monophasic nature, with minimized volatile impurities. The microscopic images exhibited homogeneous aggregates of varying shapes and sizes with an average length of about 0.5–5 μm. Eu3+doped SrGd2O4 phosphors prepared at low temperatures, showed miserably low values of red emission upon UV excitation owing to the presence of volatile impurities. The SrGd2O4:Eu3+ phosphors prepared at relatively high temperature exhibited strong red-orange emissions due to homogeneously occupied Eu3+ ions in the host lattice. The dominant red to orange(R/O) emission intensity ratios and CIE parameters of Eu3+ ions substantiated the site occupation of higher asymmetry sites of Gd3+ ions and the strong covalent nature. Dexter theory and critical distance calculation suggested that the dipole-dipole interaction could be responsible for the concentration quenching of Eu3+(4 mol.%) doped SrGd2O4 phosphors. Elevated physical and chemical durability and stable photoluminescence made these phosphors suitable for white LEDs and other display applications. | Jyoti Singh Pankaj Kr.Baitha J.Manam | 2015 | Journal of Rare Earths2015，33，10： | 7 |
| 14 | Recent advances in chronic granulomatous disease显示文摘Chronic granulomatous disease(CGD)is an inherited defect of phagocyte function due to defective NADPH oxidase.Patients with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals and are prone to recurrent bacterial and fungal infections.Inflammatory complications are also noted in CGD such as colitis,non-infective granulomas causing gastrointestinal or urinary tract obstruction,hemophagocytic lymphohistiocytosis,and arthritis.Studies on toll-like receptor pathways and neutrophil extracellular traps in CGD have shed light on the role of NADPH oxidase in the innate immunity and pathogenesis of infections in CGD.Some reports also indicate a reduction of memory B cells and defective production of functional antibodies in CGD.Though the exact mechanisms for non-infective inflammatory complications in CGD are not yet clear,studies on efferocytosis and defective autophagy with inflammasome activation have made a substantial contribution to our understanding of the pathogenesis of inflammation in CGD.We also discuss the clinical and molecular features of p40phox defects and a newer genetic defect,EROS.Clinical phenotypes of X-linked carriers of CYBB are also discussed. | Gummadi Anjani Pandiarajan Vignesh Vibhu Joshi Jitendra Kumar Shandilya Dharmagat Bhattarai Jyoti Sharma Amit Rawat | 2020 | Genes & Diseases2020，7，1： | 6 |
| 15 | Cystic lesions of peripheral nerves:Are we missing the diagnosis of the intraneural ganglion cyst?显示文摘AIM To highlight the salient magnetic resonance imaging(MRI) features of the intraneural ganglion cyst(INGC) of various peripheral nerves for their precise diagnosis and to differentiate them from other intra and extraneural cystic lesions.METHODS A retrospective analysis of the magnetic resonance(MR) images of a cohort of 245 patients presenting with nerve palsy involving different peripheral nerves was done.MR images were analyzed for the presence of a nerve lesion,and if found,it was further characterized as solid or cystic.The serial axial,coronal and sagittal MR images of the lesions diagnosed as INGC were studied for their pattern and the anatomical extent along the course of the affected nerve and its branches.Its relation to identifiable anatomical landmarks,intraarticular communication and presence of denervation changes in the muscles supplied by involved nerve was also studied.RESULTS A total of 45 cystic lesions in the intra or extraneurallocations of the nerves were identified from the 245 MR scans done for patients presenting with nerve palsy.Out of these 45 cystic lesions,13 were diagnosed to have INGC of a peripheral nerve on MRI.The other cystic lesions included extraneural ganglion cyst,paralabral cyst impinging upon the suprascapular nerve,cystic schwannoma and nerve abscesses related to Hansen's disease involving various peripheral nerves.Thirteen lesions of INGC were identified in 12 patients.Seven of these affected the common peroneal nerve with one patient having a bilateral involvement.Two lesions each were noted in the tibial and suprascapular nerves,and one each in the obturator and proximal sciatic nerve.An intra-articular connection along the articular branch was demonstrated in 12 out of 13 lesions.Varying stages of denervation atrophy of the supplied muscles of the affected nerves were seen in 7 cases.Out of these 13 lesions in 12 patients,6 underwent surgery.CONCLUSION INGC is an important cause of reversible mono-neuropathy if diagnosed early and surgically treated.Its classic MRI pattern differentiates it from other lesions of the peripheral nerve and aid in its therapeutic planning.In each case,the joint connection has to be identified preoperatively,and the same should be excised during surgery to prevent further cyst recurrence. | Jyoti Panwar Anil Mathew Binu P Thomas | 2017 | World Journal of Radiology2017，9，5： | 5 |
| 16 | Toward commercial realization of quantum dot based white light-emitting diodes for general illumination显示文摘We demonstrate the first commercial production–ready white light-emitting diodes(LEDs)for the general illumination market with red colloidal quantum dots(QDs)applied in an on–chip configuration.We show the red QDs with tunable peak emission and narrow full width at half-maximum in combination with a conventional phosphor material can lead to LED conversion efficiency improvements of 5% to 15% over commercial phosphor based LEDs at correlated color temperatures(CCTs)ranging from 5000 to 2700 K.Furthermore,the challenges associated with reliability under high temperature,high blue flux intensity,and high humidity operation have been overcome to meet consumer market requirements.Finally,a demonstrator lamp at 3000 K color temperature and 90 color rendering index(CRI)with QD based LEDs show a larger efficiency gain up to 17%,attributed to the reduced blue LED droop from the lower drive current and the lower heat sink temperature when compared to a standard phosphor based LED lamp output. | KEN TSHIMIZU MARCEL BOHMER DANIEL ESTRADA SUMIT GANGWAL STEFAN GRABOWSKI HELMUT BECHTEL EDWARD KANG KENNETH JVAMPOLA DANIELLE CHAMBERLIN OLEG BSHCHEKIN JYOTI BHARDWAJ | 2017 | Photonics Research2017，5，2： | 5 |
| 17 | Biomedical Perspective of Electrochemical Nanobiosensor显示文摘Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed. | Priti Singh Shailendra Kumar Pandey Jyoti Singh Sameer Srivastava Sadhana Sachan Sunil Kumar Singh | 2016 | Nano-Micro Letters2016，8，3： | 5 |
| 18 | Heavy Metal Accumulation in Medicinal Plants Collected from Environmentally Different Sites显示文摘Objective To estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city. Methods Soil and plant samples of Abutilon indicum, Calotropis procera, Euphorbia hirta, Peristrophe bycaliculata, and Tinospora cordifolia were collected from 3 environmentally different sites of the city: heavy traffic area (HTA), industrial area (IA), and residential area (RA). Pb, Cd, Cr, and Ni were estimated in soil and plant samples by inductively coupled plasma emission spectrometry and compared. Results The level of heavy metal was higher in soil than in plant parts studied. Accumulation of heavy metals varied from plant to plant. Pb was the highest in Calotropis procera root from HTA site and the lowest in Peristrophe bycaliculata whole plant from IA site. It was also lower in residential area than in heavy traffic area. Conclusion The level of heavy metal content differed in the same medicinal plant collected from environmentally different sites of the same city. Thus, it reiterates our belief that every medicinal plant sample should be tested for contaminant load before processing it further for medication. | JYOTI BARTHWAL SMITHA NAIR POONAM KAKKAR | 2008 | Biomedical and Environmental Sciences2008，21，4： | 5 |
| 19 | Effect of stacking sequence on physical, mechanical and tribological properties of glass-carbon hybrid composites显示文摘A study was done to determine the effect of best stacking sequence(position and orientation)on the mechanical properties,friction and wear response of hybrid composites.The main purpose of the study was to determine the best available stacking sequence for which the physical,mechanical and three body abrasive wear rate is optimum.Test for mechanical properties(tensile strength,flexural strength,inter laminar shear strength,impact strength and hardness)was done on glass-carbon hybrid composites.The composites were then subjected to test for three body abrasive wear on a designed experimental setup.Five different factors(sliding velocity,fabric weight percentage,normal load,sliding distance and abrasive particle size)varied in steps to evaluate the friction and three body abrasive wear response of the composites.The design of experiment using Taguchi’s orthogonal array and analysis of variance(ANOVA)was applied to find out minimum specific wear rate.The results revealed the significance in arrangement of two different layers of fabric(glass and carbon)and the difference in properties obtained by them.Using Taguchi experimental analysis it has been observed that three body abrasive wear rate is minimum at 72 cm/s sliding velocity,30 wt.%fabric content,80 N normal load,90 m sliding distance and 125μm abrasive particle size.The scanning electron microscope(SEM)studies revealed the dynamics of three‐body abrasive wear and underlying micro‐mechanisms that result in the analysis of three body abrasive wear. | Gaurav AGARWAL Amar PATNAIK Rajesh kumar SHARMA Jyoti AGARWAL | 2014 | Friction2014，2，4： | 4 |
| 20 | Emerging therapies in gastrointestinal cancers显示文摘Members of the receptor tyrosine kinase family, that include EGFR, ErbB-2/HER-2, ErbB-3/HER-3 and ErbB-4/ HER-4, are frequently implicated in experimental models of epithelial cell neoplasia as well as in human cancers. Therefore, interference with the activation of these growth factor receptors represents a promising strategy for de- velopment of novel and selective anticancer therapies. Indeed, a number of inhibitors that target either EGFR or HER-2, with the exception of a few that target both; have been developed for treatment of epithelial cancers. Since most solid tumors express different ErbB receptors and/or their ligands, identification of inhibitor(s), targeting multiple EGFR family members may provide a therapeutic benefit to a broader patient population. Here we describe the significance of an ErbB family of receptors in epithelial cancers, and summarize different available therapeutics targeting these receptors. It also emphasizes the need to develop pan-ErbB inhibitors and discusses EGF-Receptor Related Protein, a recently isolated negative regulator of EGFR as a potential pan-ErbB therapeutic for a wide vari- ety of epithelial cancers. | Jyoti Nautiyal Arun K Rishi Adhip PN Majumdar | 2006 | World Journal of Gastroenterology2006，12，46： | 4 |
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