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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 3 | 根治性切缘状态在接受完整结肠系膜切除术治疗的结肠癌患者中的预后价值显示文摘目的:与直肠癌的环周切缘(CRM)相比,根治性切缘(Ra?dial Margin)可能是结肠癌的潜在预后影响因素。目前尚无关于在完整结肠系膜切除术(CME)理念下探索根治性切缘对预后影响的研究。本研究旨在探索在CME治疗结肠癌前提下,根治性切缘状态对肿瘤结局的影响。方法:基于Severance医院的前瞻性结直肠癌登记系统数据,回顾性分析从2010年10月至2013年3月接受根治性切除的Ⅰ~Ⅲ期结肠癌患者资料。共834例接受CME的连续性结肠腺癌患者纳入本研究。根据根治性切缘距离将患者分为3组:A组,根治性切缘≥2 mm;B组,1 mm≤根治性切缘<2 mm;C组,根治性切缘<1 mm。比较各组的总生存期和无病生存期。 | 王枭杰 LEE J M CHUNG T KIM K M | 2020 | 结直肠肛门外科2020，26，2： | 3 |
| 4 | Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage显示文摘Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. We describe a case of a 27-year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids. He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy. Regression of the remaining tumors was observed with cessation of steroid use. However, 3 years and a half after his initial hepatic segmentectomy, he presented with recurrent tumor enlargement and intraperitoneal hemorrhage in the setting of steroid abuse relapse. Given his limited hepatic reserve, he was conservatively managed with embolization of the right accessory hepatic artery. This is the first reported case of hepatic adenoma re- growth with recidivistic steroid abuse, complicated by life-threatening hemorrhage. While athletes and bodybuilders are often aware of the legal and social ramifications of steroid abuse, they should continue to be counseled about its serious medical risks. | Nicole M Martin Barham K Abu Dayyeh Raymond T Chung | 2008 | World Journal of Gastroenterology2008，14，28： | 3 |
| 5 | Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy显示文摘AIM To reduce readmissions and improve patient outcomes in cirrhotic patients through better understanding of readmission predictors.METHODS We performed a single-center retrospective study of patients admitted with decompensated cirrhosis from January 1, 2011 to December 31, 2013(n = 222). Primary outcomes were time to first readmission and 30-d readmission rate due to complications of cirrhosis. Clinical and demographic data were collected to help describe predictors of readmission, along with care coordination measures such as post-discharge status and outpatient follow-up. Univariate and multivariateanalyses were performed to describe variables associated with readmission.RESULTS One hundred thirty-two patients(59.4%) were readmitted at least once during the study period. Median time to first and second readmissions were 54 and 93 d, respectively. Thirty and 90-d readmission rates were 20.7 and 30.1 percent, respectively. Predictors of 30-d readmission included education level, hepatic encephalopathy at index, ALT more than upper normal limit and Medicare coverage. There were no statistically significant differences in readmission rates when stratified by discharge disposition, outpatient follow-up provider or time to first outpatient visit.CONCLUSION Readmissions are challenging aspect of care for cirrhotic patients and risk continues beyond 30 d. More initiatives are needed to develop enhanced, longitudinal post-discharge systems. | Siamak M Seraj Emily J Campbell Sarah K Argyropoulos Kara Wegermann Raymond T Chung James M Richter | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 6 | Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice显示文摘Endothelin-1 (ET-1 ) 为哺乳动物的开发和生活是必要的,但是它也在 pathophysiological 条件下面在增加的心血管的风险被含有。这研究的目的是在水管和瘦、肥胖的老鼠的肾的动脉在内皮细胞层依赖者和内皮细胞层无关的回答上决定 prepro-endothelin-1 基因的 endothelial overexpression 的影响。肥胖被 high-fat-diet (HFD ) 导致在有 prepro-endothelin-1 基因的 Tie-1 倡导者驱动的、内皮细胞层特定的 overexpression 的老鼠的消费(TET het ) 并且在里面野类型(WT ) 一个 C57BL/6N 背景上的同窝出生的人。等轴的紧张在戒指被测量(与内皮细胞层) 主动脉(A) ,颈动脉(CA ) 并且肠骨(IA ) 动脉象一样主要(MRA ) 并且部分肾(SRA ) 动脉;所有实验在 L 名字或 COX 禁止者 meclofenamate 的缺席或存在被进行。prostacyclin 和 thromboxane A2 的版本被 ELISA 测量。在 MRA, TET het 本身增加了收缩到 endothelin-1,但是反应响应血清素在 SRA 被减少;面对 L 名字在 SRA 到醋胆素然而并非胰岛素有也改进的松驰。HFD 本身扩充了收缩到 endothelin-1 (MRA ) 并且到 thromboxane prostanoid (TP ) 受体收缩筋 U46619 (CA, MRA ) 象到 isoproterenol (A) 的便于的松驰一样。HFD 和 TET het overexpression 增加了 MRA 和 SRA 的收缩到 vasoconstrictors 然而并非面对 meclofenamate;这联合也在 A 扩充了进一步的松驰到 isoproterenol。到在 IA 的 endothelin-1 的收缩被 endothelin 阻止 -- 受体对手 BQ-123 但是仅仅由 BQ-788 在肥胖的老鼠稀释了。COX-1 禁止者 FR122047 废除了 CA 的收缩到醋胆素。prostacyclin 的版本从肥胖的 TET het 老鼠并且由 FR122047 废除了。这些调查结果建议那 endothelial TET 在瘦动物的 het overexpression 在脉管的应答上有最小的效果。不管多么有肥胖的 comorbid, endothelin-1-modulated,调停 prostanoid 的肾的动脉的机能障碍变得明显。 | Oliver BARETELLA Sookja K CHUNG Aimin XU Paul M VANHOUTFE | 2017 | Acta Pharmacologica Sinica2017，38，4： | 2 |
| 7 | Relationship between organic matter content of soil and the sequestration of phenanthrene显示文摘 | Nam K Chung N Alexander M | 1998 | Environ Sci Technol1998，32，23： | 1 |
| 8 | Pollutants in Hong Kong soils: Potycyclic aromatic hydrocarbons显示文摘 | CHUNG M K HU R CHEUNG K C | 2007 | Chemosphere2007，67，3： | 1 |
| 9 | Peripheral gangreme associatedwith Kawasaki disease显示文摘 | Tomita S Chung K Mas M | 1992 | Clin Infect Dis1992，14，： | 1 |
| 10 | The clinical usefulness of (18)F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies显示文摘 | BAEK C H CHUNG M K JEONG H S | 2009 | Korean J Radiol2009，10，1： | 1 |
| 11 | Inactivation of barotolerant Listeria monocytogenes in sausage by combination of high-pressure processing and food-grade additives显示文摘 | Chung Y K Vurma M Turek E J | 2005 | Journal of Food Protection2005，68，4： | 1 |
| 12 | Higher energy synchronized external direct current cardioversion for refractory atrial fibrillation显示文摘 | Saliba W Juratli N Chung M K | 1999 | J Am Coll Cardiol1999，34，7： | 1 |
| 13 | A discontinuous Galerkin method for the Rosenau equation显示文摘 | Choo S M Chung S K Kim K I | 2008 | Appl Numerical Mat2008，58，： | 1 |
| 14 | MR-387 A and B, new aminopeptidase N inhibitors, produced by Streptomyces neyagawaensis SL-387显示文摘 | Chung M C Chun H K Han K H | 1996 | J Antibiot (Tokyo)1996，49，1： | 1 |
| 15 | microRNA directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems 显示文摘 | Kim J Jung J H Reyes J L kim Y S Kim S Y Chung K S Kiln J A Lee M Lee Y Kim V N | 2005 | The Plant Journal2005，42，： | 1 |
| 16 | Effect of electric fields on the stabilization of premixed laminar Bunsen flames at low AC frequency: Bi-ionic wind effect显示文摘 | KIM M K CHUNG S H KIM H H | 2012 | Combustion and Flame2012，159，3： | 1 |
| 17 | Lossless frame memory recompression for video codec preserving random accessibility of coding unit显示文摘 | LEE S H CHUNG M K PARK S M | 2009 | IEEE transactions on consumer electronics2009，55，4： | 1 |
| 18 | Directconverison of cellulose into polyols or H2 over P t/N a (H )-Z S M -5 显示文摘 | YOU S J BEAK I G KIM Y T JEONG K E CHAE H J KIM T W KIM C U KIM T J CHUNG Y M OH S H PARK E D | | Korean J Chem Eng0，28，3： | 1 |
| 19 | C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation显示文摘 | CHUNG M K MARTIN D O SPRECHER D | 2001 | Circulation2001，104，： | 1 |
| 20 | PG490-88,a derivative of triptolide,causes tumor regression and sensitizes tumors to chemotherapy显示文摘 | Fidler J M Li K Chung C | 2003 | Mol Cancer Ther2003，2，9： | 1 |
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