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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Favorable response to high-dose infliximab for refractory childhood uveitis 显示文摘 | Kalm P Weiss M Imundo LF Levy DM | 2006 | Oph- thalmology2006，113，5： | 1 |
| 3 | Metastatic prostate cancercomplicated with chronic disseminated intravascular coagulopa-thy causing acute renal failure,mimicking thrombotic thrombo-cytopenic purpura and hemolytic uremic syndrome:pathomech-anism,differential diagnosis and therapy related to a case显示文摘 | Deme D Ragán M Kalmár K | 2010 | Magy Onkol2010，54，4： | 1 |
| 4 | Numerical analysis of the dynamic effects of shock-load-induced ice shedding on overhead ground wires 显示文摘 | Kalm n T Farzaneh M McClure G | 2007 | Computers and Structures2007，85，78： | 1 |
| 5 | Personal use of hair dyes and risk of bladder cancer: A meta-analysis of epidemiologic data显示文摘 | Kelsh M A Alexander D D Kalmes R M | 2008 | Cancer Causes Control2008，19，6： | 1 |
| 6 | Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells显示文摘 | Kalme T Koistinen H Loukovaara M | 2003 | J Steroid Biochem Mol Biol2003，86，： | 1 |
| 7 | The solution of linear difference models under rational expectations 显示文摘 | Blanchard O J Kalm C M | 1980 | Econometrica: Journal of the Econometric Society1980，48，： | 1 |
| 8 | Eustachian tube function and tympatic membrane findings after chronic secretory otitis raedia显示文摘 | Ryding M White P Kalm O | 2004 | Int J Pediatr Otorhinolaryngol2004，68，2： | 1 |
| 9 | Course and long-term outcome ofrefractory secretory otitis media显示文摘 | Ryding M White P Kalm O | 2005 | J laryngol Otol2005，119，2： | 1 |
| 10 | A serine-kinase associated with the p127-1(2) gl tumour suppressor of Drosophila may regulate the binding of p127 to nonmuscle myosin Ⅱ heavy chain and the attachment of p127 to the plasma membrane显示文摘 | Kalmes A Merdes G Neumann B Strand D Mechler B M | 1996 | J Cell Sci1996，109，6： | 1 |
| 11 | Targeted radiopharmaceutical therapy for advanced lung cancer: phase I trial of rhenium Re188 p2045, a somatostatin analog显示文摘 | Edelman M J Clamon G Kalm D | 2009 | J Thorac Oncol2009，4，12： | 1 |
| 12 | Eustachian tube function and tympatic membrane findings after chronic secretory otitis media显示文摘 | White P kalm O | 2004 | Int J Pediatr Otorhinolaryngol2004，68，2： | 1 |
| 13 | Eustachian tube function and tympatic membrane findings after chronic secretory otitis media显示文摘 | Ryding M White P Kalm O | 2004 | Int J Pediatr Otorhinolaryngol2004，68，2： | 1 |
| 14 | Course and long-term outcome of refractory secretory otitis media显示文摘 | Ryding M White P Kalm O | 2005 | J laryngolotol2005，119，2： | 1 |
| 15 | Personal use of hair dyes and risk of bladder cancer: A meta-analysis of epidemiologic data 显示文摘 | Kelsh M A Alexander D D Kalmes R M | 2008 | Cancer Cauls and Control2008，19，6： | 1 |
| 16 | Extension of saphenous thrombus into the femoml vein:a potential complication of new endovenous ablation techniques显示文摘 | Mozes G Kalm M Camo M | 2005 | J Vasc Surg2005，41，2： | 1 |
| 17 | Extension of saphenous thrombus into the femoral vein:a potential complication of new endovenous ablation techniques 显示文摘 | Mozes G Kalm M Camo M | 2005 | J Vasc Surg2005，41，： | 1 |
| 18 | Eustachian tube function and tympanic membrane findings after chronic secretory otitis media显示文摘 | Ryding M White P Kalm O | 2004 | Int J Pediatr O- torhinolaryngol2004，68，2： | 1 |
| 19 | Estradiol increases the production of sex hormone-binding globulin but not insulin-like growth factor binding protein-1 in cultured human hepatoma cells 显示文摘 | Kalme T Loukovaara M Koistinen R | 1999 | Fertil Steril1999，72，2： | 1 |
| 20 | Irradiation-induced loss of microglia in the young brain显示文摘 | Kalm M Lannering B Bjrk-Eriksson T | 2009 | J Neuroimmunol2009，206，12： | 1 |
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