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| 1 | Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget’s disease with curative responses显示文摘Background:Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease(EMPD)of the genital region is wide surgical excision of the lesion,the procedure is highly invasive and can lead to functional and sexual problems.Alternative treatments have been used for local control when wide local exci-sion was not feasible.Here,we describe four patients with genital malignancies who were treated with boron neutron capture therapy(BNCT).Methods:The four patients included one patient with vulvar melanoma(VM)and three with genital EMPD.They underwent BNCT at the Kyoto University Research Reactor between 2005 and 2014 using para-boronophenylalanine as the boron delivery agent.They were irradiated with an epithermal neutron beam between the curative tumor dose and the tolerable skin/mucosal doses.Results:All patients showed similar tumor and normal tissue responses following BNCT and achieved complete responses within 6 months.The most severe normal tissue response was moderate skin erosion during the first 2 months,which diminished gradually thereafter.Dysuria or contact pain persisted for 2 months and resolved com-pletely by 4 months.Conclusions:Treating VM and EMPD with BNCT resulted in complete local tumor control.Based on our clinical expe-rience,we conclude that BNCT is a promising treatment for primary VM and EMPD of the genital region. | Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth Koji Ono | 2018 | Cancer Communications2018，38，1： | 10 |
| 2 | Laparoscopic cholecystectomy in situs inversus totalis with “inferior” cystic artery: A case report显示文摘A 76-year-old man with known situs inversus totalis presented with left-sided discomfort. Abdominal ultrasonography and CT scan confirmed the diagnosis of a gallstone, as well as,situs inversus; the liver and gallbladder on the left side and the spleen on the right. The biliary system was thought to be left-right reversal, mirror image in the view of drip infusion cholangiogram and MRI. Laparoscopic cholecy stectomywas safely performed, despite of unexpected aberrant cystic artery running inferior to cystic duct of situs inversus.Laparoscopic surgeon should be careful for view of reversed relationships and also existence of other anomalies. | Sumihiro Kamitani Yosihiro Tsutamoto Kazuyoshi Hanasawa Tohru Tani | 2005 | World Journal of Gastroenterology2005，11，33： | 8 |
| 3 | 硼中子俘获治疗外阴黑色素瘤和生殖器乳腺外Paget病的疗效显示文摘背景与目的尽管目前对生殖器区的黑色素瘤和乳腺外Paget病(extramammary Paget’s disease,EMPD)最常推荐的治疗方法是广泛性手术切除病变,但该方法侵害性极高并可导致功能性和性方面的问题。当扩大局部切除术不可行的情况下,替代疗法已被用于进行局部控制。本研究描述了4例接受硼中子俘获治疗(boron neutron capture therapy,BNCT)的生殖器恶性肿瘤患者。方法 4例患者中包括1例外阴黑色素瘤(vulvar melanoma,VM)和3例生殖器EMPD患者。他们于2005至2014年间在Kyoto大学研究堆接受了对二羟基硼酰苯丙氨酸作为硼携带剂的BNCT治疗。他们接受了介于治愈性肿瘤剂量和可耐受的皮肤/黏膜剂量之间的超热中子束照射。结果所有患者在BNCT治疗后均表现出相似的肿瘤和正常组织反应,并在6个月内达到完全缓解。最严重的正常组织反应前2个月内出现,随后逐渐减弱的中度皮肤糜烂,排尿困难或接触性疼痛持续2个月,完全解决需4个月。结论 BNCT治疗VM和EMPD后局部肿瘤得到完全控制。根据我们的临床经验,我们认为BNCT是治疗生殖器区原发性VM和EMPD的一种有前景的方法。 | Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth Koji Ono | 2018 | 癌症2018，37，7： | 3 |
| 4 | 腮腺肿瘤:动态增强MRI加用扩散加权MRI能提高定性诊断的准确性吗?显示文摘目的 明确动态增强MRI加扩散加权成像(DWI)在鉴别腮腺良恶性肿瘤的价值。材料和方法 本项回顾性研究经机构委员会批准,免除知情同意。分析了47例病人50个病灶(36个良性、14个恶性)。所有病人都接受了扩散加权MRI和动态增强MRI。 | H. Yabuuchi Y. Matsuo T. Kamitani T. Setoguchi T. Okafuji H. Soeda 王大丽 | 2009 | 国际医学放射学杂志2009，32，1： | 2 |
| 5 | Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese显示文摘 | Kamitani A Rakugi H Higaki J | 1994 | J Hum Hypertens1994，8，7： | 1 |
| 6 | Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1显示文摘 | Zhang G Kobayashi T Kamitani W | 2003 | J Virol2003，77，12： | 1 |
| 7 | Recurrence of convexity menin-giomas:tumor cells in the arachnoid membrane 显示文摘 | Kamitani H Masuzawa H Kanazawa I | 2001 | Surg Neurol2001，56，4： | 1 |
| 8 | Effects of propofol on isolated rabbit mesenteric artries and veins显示文摘 | KAMITANI K YAMAZAKI M YUKITAKA M | 1995 | Br J Anaesth1995，75，4： | 1 |
| 9 | An empirical model for predicting the gap light index in an evenaged oak stand显示文摘 | Yoshida T Yanagisawa Y Kamitani T | 1998 | Forest Ecology and Management1998，109，1： | 1 |
| 10 | Effect of mild heat pretreatment with alkaline electrolyzed water on the efficacy of acidic electrolyzed water against Escherichia coli O157 : H7 and Salmonella on Lettuce显示文摘 | KOSEKI S YOSHIDA K KAMITANI Y | 2004 | Food Microbiology2004，21，5： | 1 |
| 11 | Rare earth minerals and resources in the world显示文摘 | Kanazawa Y Kamitani M | 2006 | Journal of Alloys and Compounds2006，408，： | 1 |
| 12 | Correlations between apparent diffusion coefficient values and prog- nostic factors of breast cancer显示文摘 | Kamitani T Matsuo Y Yabuuchi H | 2013 | Magn Reson Med Sci2013，12，3： | 1 |
| 13 | Application of slightly acidic electrolyzed water as a potential non-thermal food sanitizer for decontamination of fresh ready-to-eat vegetables and sprouts 显示文摘 | Zacharia A I Kamitani Y Miwa N | 2011 | Food Control2011，22，： | 1 |
| 14 | Boma disease virus phosphoprotein binds a neurite outgrowth factor, amphotetin/HMG-1显示文摘 | Kamitani W Shoya Y Kobayashi T | 2001 | J Virol2001，75，18： | 1 |
| 15 | Cytogenetic heterogeneity and progression of esophageal squamous cell carcinoma 显示文摘 | Shiomi H Sugihara H Kamitani S | 2003 | Cancer Genet Cytogenet2003，147，1： | 1 |
| 16 | Histone acetylation may suppress human glioma cell proliferation when p21WAF1 and gelsolin are induced显示文摘 | Kamitani H Taniura S Watanabe K | 2002 | Neuro Oncol2002，4，2： | 1 |
| 17 | Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice显示文摘 | Kamitani W Ono E Yoshino S | 2003 | Proc Natl Acad Sci U S A2003，100，15： | 1 |
| 18 | In vitro inactiva- tion of Escherichia coli,Staphylococcus aureus and Salmonella spp using slightly acidic electrolyzed water显示文摘 | Issa - Zacharia A Kamitani Y Tiisekwa A | 2010 | J Biosci Bioeng2010，110，3： | 1 |
| 19 | Non-mass-like enhancement on contrast-enhanced breast MR imaging:lesion characterization using combination of dynamic contrastenhanced and diffusion-weighted MR images显示文摘 | Yabuuchi H Matsuo Y Kamitani T | 2010 | Eur J Radiol2010，75，1： | 1 |
| 20 | Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1 显示文摘 | Kamitani W Shoya Y Kobayashi T | 2001 | J Virol2001，75，18： | 1 |
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