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| 1 | Acute respiratory distress syndrome and lung injury: Pathogenetic mechanism and therapeutic implication显示文摘To review possible mechanisms and therapeutics for acute lung injury(ALI) and acute respiratory distress syndrome(ARDS). ALI/ARDS causes high mortality. The risk factors include head injury, intracranial disorders, sepsis, infections and others. Investigations have indicated the detrimental role of nitric oxide(NO) through the inducible NO synthase(i NOS). The possible therapeutic regimen includes extracorporeal membrane oxygenation, prone position, fluid and hemodynamic management and permissive hypercapnic acidosis etc. Other pharmacological treatments are anti-inflammatory and/or antimicrobial agents, inhalation of NO, glucocorticoids, surfactant therapy and agents facilitating lung water resolution and ion transports. β-adrenergic agonists are able to accelerate lung fluid and ion removal and to stimulate surfactant secretion. In con-scious rats, regular exercise training alleviates the endotoxin-induced ALI. Propofol and N-acetylcysteine exert protective effect on the ALI induced by endotoxin. Insulin possesses anti-inflammatory effect. Pentobarbital is capable of reducing the endotoxin-induced ALI. In addition, nicotinamide or niacinamide abrogates the ALI caused by ischemia/reperfusion or endotoxemia. This review includes historical retrospective of ALI/ARDS, the neurogenic pulmonary edema due to head injury, the detrimental role of NO, the risk factors, and the possible pathogenetic mechanisms as well as therapeutic regimen for ALI/ARDS. | Chain-Fa Su Shang Jyh Kao Hsing I Chen | 2012 | World Journal of Critical Care Medicine2012，1，2： | 12 |
| 2 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 3 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 4 | RNA motifs that determine specificity between a viral replicase and its promoter显示文摘 | Kim C Kao C C Tinoco I | 2000 | Nat Struct Biol2000，7，： | 1 |
| 5 | Detection of the high-level aminoglycoside resistance gene aph (2')-Ib in Enterococcus faecium显示文摘 | Kao SJ You I Clewell DB | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 6 | Development and Validation of the Inventory of Perceptions of Medication Administration Errors for Nurses in Taiwan 显示文摘 | Kao Chia-Chan Lin Yu-Hua Lee I | 2015 | Medica Care2015，23，1： | 1 |
| 7 | Association of novelty seeking scores and striatal dopamine D2/D3 receptor availability of healthy volunteers: Single photon emission computed tomography with 123I-iodobenzamide显示文摘 | HSIANG YH I HUI LE KAO CC | 2010 | J Formos Med Assoc2010，109，10： | 1 |
| 8 | Detection of the High-Level Aminoglycoside Resistance Gen aph(2″)-Ib in Enterococcus faecium显示文摘 | Kao SJ You I Clewell DB | 2000 | Antimicrob Agents Chemother2000，44，10： | 1 |
| 9 | Flap endonuclease 1: a central component of DNA metabolism显示文摘 | Liu Y Kao H I Bambara R A | 2004 | Annu Rev Biochem2004，73，7： | 1 |
| 10 | Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats 显示文摘 | Lee W K Kao S T Liu I M | 2007 | Horm Metab Res2007，39，5： | 1 |
| 11 | The Melt Extensibility of Polypropylene 显示文摘 | S Muke I Ivanov N Kao S N Bhattacharya | 2001 | Polymer International2001，50，5： | 1 |
| 12 | Diurnal leaf movement, chlomphyll fluorescence and carbon assimilation in soybean grown under different nitrogen and water availabilities 显示文摘 | Kao W Y Forseth I N | 1992 | Plant Cell Enciro1992，15，： | 1 |
| 13 | Extensional Rheology of Polypropylene Melts From the Rheotens Test显示文摘 | S Muke I Ivanov N Kao S N Bhattacharya | 2001 | Jounal of Non-Newtonian Fluid Mechanics2001，101，13： | 1 |
| 14 | Dacryocystorhi- nostomy with intraopemtive mitomycin C 显示文摘 | KAO S C LIAL C I TSENG J H | 1997 | Ophthalmol- ogy1997，106，： | 1 |
| 15 | Structure/property relationship in polyolefins made by constrained geometry catalyst technology显示文摘 | CHUM P S KAO C I KNIGHT G W | 1995 | Plast Eng1995，51，6： | 1 |
| 16 | Galerkin-based Modal Analysis on the Vibration of Wire-slurry System in Wafer Slicing Using a Wire Saw 显示文摘 | Zhu L Kao I | 2005 | Journal of Sound and Vibration (S0022-460X)2005，283，3： | 1 |
| 17 | Clinical :features of influenza A and B in children and association with myositis显示文摘 | Hu J J Kao C L Lee P I | 2004 | J Mierobiol Immunol Infect2004，37，2： | 1 |
| 18 | Modeling stresses of contacts in wire saw slicing of polycrystalline and crystalline ingots:Application to silicon wafer production显示文摘 | Kao I Prasad V | 1998 | Transactions of the ASME Journal of Electronic Packaging1998，120，： | 1 |
| 19 | Viscolin,a new chal-cone from Viscum coloratum,inhibits human neutrophil superox-ide anion and elastase release via a cAMP-dependent pathway显示文摘 | Hwang T L Leu Y L i Kao S H | 2006 | Free Radic Biol Med2006，41，9： | 1 |
| 20 | Testosterone perburbs epidermal permeability bartier homeostasis 显示文摘 | I Kao JS Garg A Man MQ | 2001 | J Invest Dermatol2001，116，3： | 1 |
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