|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 2 | 推荐以“EBV相关肺癌”术语替代和扩展肺淋巴上皮瘤样癌的组织学谱系显示文摘肺淋巴上皮瘤样癌(LELC)是一种罕见的EBV相关性癌,其组织学特征为癌细胞呈合体细胞样生长,伴显著的淋巴细胞浸润,组织学上与未分化型鼻咽癌难以区分。研究发现LELC亦可显示非经典组织学形态且缺乏显著的淋巴细胞浸润。作者选取61例肺LELC病例进行全面临床病理分析,并使用免疫组化分析软件对浸润淋巴细胞进行自动定量分析,发现肺LELC形态学上存在连续性谱系,呈现从富于淋巴细胞浸润的经典型未分化LELC至极少淋巴细胞浸润的非经典型组织学形态。 | Yeh Y C Kao H L Lee K L | 2019 | 临床与实验病理学杂志2019，35，5： | 12 |
| 3 | 肾脏恶性孤立性纤维性肿瘤过表达BCOR:模拟肾脏透明细胞肉瘤显示文摘BCOR是诊断肾脏透明细胞肉瘤(CCSK)的一种敏感且高度特异的标志物。然而,过表达BCOR的成人肾脏肉瘤中有一部分BCOR基因遗传学改变(包括BCOR基因融合或BCOR内部串联重复)却呈阴性,因此被归为不能分类的肾脏肉瘤。作者报道了5例肾脏/肾周未分化肉瘤,鉴于其形态学特征和高表达BCOR,提示需与CCSK进行鉴别,但经过RNA测序证实为恶性孤立性纤维性肿瘤(SFTs)。发病年龄30~62岁,女性3例,男性2例。4例为原发性肾脏肿瘤,1例为肾周肿瘤。5例肿瘤均为富于细胞性、非多形性的未分化肉瘤,具有毛细血管分支,由圆形至卵圆形肿瘤细胞组成,胞质稀少,核规则,染色质均匀分布。5例中均未出现SFTs的典型特征,如浓染的梭形核、明显的胶原沉积或血管外皮瘤样结构。5例BCOR均强阳性。3例CD34阴性,2例CD34仅局灶阳性。随后免疫组化结果发现,5例STAT6均阳性。 | 魏建国(摘译) 方三高(审校) Argani P Kao Y C Zhang L | 2019 | 临床与实验病理学杂志2019，35，8： | 3 |
| 4 | MUC4阴性的硬化性上皮样纤维肉瘤亚型可检出伴高频性YAP1和KMT2A基因重排显示文摘硬化性上皮样纤维肉瘤是一种侵袭性软组织肉瘤,其组织学特征为在致密硬化的胶原间质内散在上皮样细胞,免疫组化标志物MUC4常阳性,通常存在包括EWSR1在内的基因融合。由于与低度恶性纤维黏液样肉瘤在组织形态和遗传学特征方面有一些重叠,推测两者发病机制可能存在关联。实验显示有一小部分硬化性上皮样纤维肉瘤免疫组化MUC4阴性,且缺乏典型EWSR1/FUS基因重排。作者最初发现3例为MUC4阴性及EWSR1/FUS基因重排阴性的硬化性上皮样纤维肉瘤,经靶向RNA测序检测发现存在YAP1-KMT2A融合。 | Kao Y C Lee J C Zhang L 王婷(摘译) 余英豪(审校) | 2020 | 临床与实验病理学杂志2020，36，8： | 2 |
| 5 | A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes显示文摘 | Kao Y L Donaghue K Chan A | | 0，，： | 2 |
| 6 | Convective heat transfer to water containing bubbles:enhancement not dependent on thermocapillarity 显示文摘 | KENNING D B R KAO Y S | 1972 | Int J Heat Mass Transfer1972，15，： | 2 |
| 7 | Ca^2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements 显示文摘 | Kao J P Tsien R Y | 1988 | Biophys J1988，53，4： | 1 |
| 8 | Lax-Friedrichs sweeping scheme for static Hamihon-Jacobi equations 显示文摘 | C Y Kao S Osher J Qian | 2004 | Journal of Computational Physics2004，196，1： | 1 |
| 9 | Evaluation on the wear,tension and fatigue behavior of various PVD coated materials显示文摘 | SU Y L WU C T KAO W H | 1998 | Materials Letters1998，35，34： | 1 |
| 10 | Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2008update显示文摘 | Liaw Y F Leung N Kao J H | 2008 | Hepatol Int2008，2，3： | 1 |
| 11 | Accurate image reconstruction from few views and limited angle data in divergent beam CTc显示文摘 | Emil Y S Kao C Pan X | 2006 | Jr*urna! o/X- Ray Seiezzce and Teehnology2006，14，2： | 1 |
| 12 | Influence of thermal effect on output power optimization in fiber-coupled laser- diode end-pumped lasers 显示文摘 | Chert Y F Huang T M Kao C F | 1997 | IEEE J Quantum Electron1997，3，1： | 1 |
| 13 | Modulation of endocrine systems and food intake by green tea epigalloeatechin gallate 显示文摘 | Kao Y H Hiipakka R A IAao S | 2000 | Endocrinology2000，141，98： | 1 |
| 14 | Retrieval of surface parameters u- sing dynamic learning neutral network 显示文摘 | Chen K S Kao W L Tzeng Y C | 1995 | International Journal of Remote Sensing1995，16，5： | 1 |
| 15 | Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74 显示文摘 | Lau R W Ho P L Kao R Y | 2011 | Antimicrob Agents Chemother2011，55，2： | 1 |
| 16 | Treatment of distal femoral fracture by minimally invasive percutaneous plate osteosynthesis:comparison between the dynamic condylar screw and the less invasive stabilization system显示文摘 | Kao F C Tu Y K Su J Y | | 0，，07： | 1 |
| 17 | Decision trees for uncertain data显示文摘 | Smith Tsang Ben Kao Kevin Y YIP | | 0，，01： | 1 |
| 18 | 查看详情显示文摘 | Hsu J P Kao C Y Tseng S J Chen C J | | 0，，： | 1 |
| 19 | MDA5plays a crucial role in enterovirus 71RNA-mediated IRF3 activation显示文摘 | Kuo R L Kao L T Lin S J Wang R Y Shih S R | 2013 | PLoS One2013，8，63： | 1 |
| 20 | Evaluating the compatibility of three colorimetric protein assays for two-dimensional electrophoresis experiments显示文摘 | KAO S H WONG H K CHIANG C Y | 2008 | Proteornics2008，8，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员