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| 1 | Rituximab for troublesome cases of childhood nephrotic syndrome显示文摘Nephrotic syndrome(NS) is the most common glomerular disease of childhood. Steroid-dependent and steroid-resistant nephrotic syndrome present challenges in their pharmaceutical management; patients may need several immunosuppressive medication for optimum control, each of which medication has its own safety profile. Rituximab(RTX) is a monoclonal antibody that targets B cells and has been used successfully for management of lymphoma and rheumatoid arthritis. Recent clinical studies showed that rituximab may be an efficacious and safe alternative for the treatment of complicated nephrotic syndrome. In this review article, we aim to review the efficacy and safety of RTX therapy in nephrotic syndrome. We reviewed the literature pertaining to this topic by searching for relevant studies on Pub Med and Medline using specific keywords. The initial search yielded 452 articles. These articles were then examined to ensure their relevance to the topic of research. We focused on multicenter randomized controlled trials with relatively large numbers of patients. A total of 29 articles were finally identified and will be summarized in this review. The majority of clinical studies of RTX in complicated pediatric NS showed that rituximab is effective in approximately 80% of patients with steroid-dependent NS, as it decreases the number of relapses and steroid dosage. However, RTX is less effective at achieving remission in steroid-resistant NS. RTX use was generally safe, and most side effects were transient and infusion-related. More randomized, double-blinded clinical studies are needed to assess the role of RTX in children with nephrotic syndrome. | Osama Y Safdar Adila Aboualhameael Jameela A Kari | 2014 | World Journal of Clinical Pediatrics2014，3，4： | 5 |
| 2 | GATA-3 is involvedin the development of serotonergic neurons in the caudal raphe nuclei显示文摘 | van Doominck JH van Der Wees J Karis A | 1999 | J Neurosci1999，19，12： | 1 |
| 3 | Acta Chim Scand显示文摘 | Carlsen P H J S(o)rbye K Ulven T Kari A | 1996 | 50:1851996，50，： | 1 |
| 4 | Serum paraoxonase activity and phenotype distribution in Turkish subjects with coronary heart disease and its relationship to serum lipids and lipoproteins 显示文摘 | Kara Kary A Ibis S Kural T | 1999 | Chem Biol Interact1999，118，3： | 1 |
| 5 | Pseudo-Continuous-Time Readout Circuit for a 300 /s Capacitive 2-Axis Micro-Gyroscope 显示文摘 | Lasse Aaltonen Kari A I Halonen | 2009 | IEEE JSSC2009，44，12： | 1 |
| 6 | Metabolic syndrome and chronic kidney disease显示文摘 | Singh A K Kari J A | 2013 | Current opinion in nephrology and hypertension2013，22，2： | 1 |
| 7 | Description of the new I1011 beamline for magnetic measurements using synchrotron radiation at MAX-lab显示文摘 | I A Kowalik G ?hrwall B N Jensen R Sankari E Wallén U Johansson O Karis D Arvanitis | 2010 | Journal of Physics: Conference Series2010，，1： | 1 |
| 8 | Gene expression analysis of Gata3 /- mice by using cDNA microarray technology显示文摘 | Airik Po K rner M Karis A | 2005 | Life Sci2005，76，： | 1 |
| 9 | Profile of hot surface by pulsed time-of-flight laser range finder techniques显示文摘 | Juha Kostamovaara Risto Myllyla¨ | 1993 | App lied Optics1993，32，272020： | 1 |
| 10 | Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma显示文摘 | Kari L Loboda A Nebozhyn M | 2003 | J Exp Med2003，197，11： | 1 |
| 11 | Stroke incidence, case fatality,and mortality in the WHO MONICA project显示文摘 | Per T Kjell A Kari L | 1995 | Stroke1995，，26： | 1 |
| 12 | Infections in patients with rheumatoid arthritis treated with biologic agents显示文摘 | LISTING J STRANGFELD A KARY S | 2005 | Arthritis Rheum2005，52，11： | 1 |
| 13 | Regional blood flow and oxygen trans-port insepsic shock显示文摘 | Esko E Takala J Kari A | 1993 | Crit Care Med1993，21，： | 1 |
| 14 | Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy显示文摘 | Sergio D Margaret C Kari A | 2002 | Blood2002，99，6： | 1 |
| 15 | Regional blood flow and oxygen transport in septic shock显示文摘 | Esko E Takala J Kari A | 1993 | Crit Care Med1993，21，： | 1 |
| 16 | Optimisation of supercritical fluid extraction of indole alkaloids from catharanthus roseus using experimental design methodology-comparison with other extraction techniques 显示文摘 | VERMA A KARI H MARJA-LIISA R | 2008 | Phytochem Anal2008，19，1： | 1 |
| 17 | Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency adimissions显示文摘 | Suistoma M Ruokonen E Kari A | 2000 | Shock2000，14，1： | 1 |
| 18 | Oentamicin negatively influenced osteogenic function in vitro 显示文摘 | Ince A Schutze N Kari N | 2007 | Int Orthop2007，31，2： | 1 |
| 19 | In vivo radioproteetion by the fullerene nanopartiele DF -1 as assessed in a zebrafish model 显示文摘 | Daroczi B Kari G McAleer M F Wolf J C Rodeck U Dieker A P | 2006 | Clin Cancer Res2006，12，： | 1 |
| 20 | Regional blood flow and oxy- gen transport in septic shock显示文摘 | Ruokonen E Takala J Kari A | 1993 | Crit Care Med1993，21，9： | 1 |
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