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| 1 | Metrafenone: Studies on the Mode of Action of a Novel Cereal Powdery Mildew Fungicide显示文摘 | KRYSTINA S O STEFAN T KARL H K | 2006 | Pest Management Science2006，，62： | 4 |
| 2 | The effect of pulsed electric fields on biological cells: experiments and applications显示文摘 | Schoenbach Karl H | 1997 | IEEE Trans on plasma science1997，25，2： | 2 |
| 3 | The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells显示文摘Streptococcus mitis(S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor(Ah R). Activation and functionality of Ah R was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for Ah R activation. Addition of Streptococcus mutans or Streptococcus gordonii did not induce CYP1A1 transcription in the keratinocyte cultures. Introduction of an Ah R-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by Ah R. Elevated levels of prostaglandin E2(enzyme-linked immunosorbent assay) in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of Ah R activity. The observed Ah R-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce Ah R activation is important, also in view of the role that Ah R has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophages. | stian a engen gro h rørvik olav schreurs inger js blix karl schenck | 2017 | International Journal of Oral Science2017，9，3： | 2 |
| 4 | Management practices of hepatitis C virus infected alcoholic hepatitis patients:A survey of physicians显示文摘AIM:To survey gastroenterologists and hepatologists regarding their current views on treating hepatitis C virus(HCV) infected alcoholic hepatitis(AH) patients.METHODS:A sixteen item questionnaire was electronically mailed to gastroenterologists and hepatologists.A reminder was sent after 2 mo to increase the response rate.Participation of respondents was confidential.Accessing secured web site to respond to the questionnaire was considered as informed consent.Responses received on the secured website were downloaded in an excel sheet for data analysis.RESULTS:Analyzing 416 responses to 1556(27% response rate) emails,57% respondents(56% gastroenterologists) reported HCV prevalence > 20% amongst AH patients.Sixty nine percent often treated AH and 46% preferred corticosteroids(CS).Proportion of respondents with consensus(75% or more respondents agreeing on question) on specific management of HCV infected AH were:routine HCV testing(94%),HCV not changing response to CS(80%) or pentoxifylline(91%),no change in approach to treating HCV infected AH(75%).None of respondent variables:age,specialty,annual number of patients seen,and HCV prevalence could predict respondent to be in consensus on any of or all 4 questions.Further,only 4% would choose CS for treating HCV infected AH as opposed to 47% while treating HCV negative AH.CONCLUSION:Gastroenterologists and hepatologists believe that AH patients be routinely checked for HCV.However,there is lack of consensus on choice of drug for treatment and outcome of HCV positive AH patients.Studies are needed to develop guidelines for management of HCV infected AH patients. | Ashwani K Singal Habeeb Salameh Anjna Singal Sarat C Jampana Daniel H Freeman Karl E Anderson Don Brunder | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 2 |
| 5 | 挪威海底公路隧道经验——施工、运行、 费用和维护(英文)显示文摘根据2002年关于挪威海底公路隧道的一论文集(挪威公路管理局公路技术部编辑,题目为'论文集98——挪威海底公路隧道',将详细阐述挪威海底隧道的施工建造等经验。挪威第一条海底公路隧道是在1983年通车的,随后建成了另外24条海底公路隧道,至今共有25条海底公路隧道建成通车,总长度达100km。几条新的海底公路隧道目前正在建设中,还有几条则在规划当中,其中最长将达24km。大多数条海底公路隧道是单洞双线,但是当坡度大于6%时,有些隧道就增加一条线。海底公路隧道都位于沿海岸线的干线公路上,以代替原有的繁忙的轮渡,并建立大陆与当地之间的无轮渡连接。据此,主要介绍这些隧道工程中得到的经验,总的来说,海底公路隧道的建设费用逐渐降低,但是各工程间差异很大,各个隧道的运行和维护的费用也相差悬殊,再投资和设备花费也特别高。经验表明,随着渗水量逐年减少,因而抽出渗透水的要求也降低了。介绍了1996年前17条海底隧道中发生的事故和火灾,对19起造成人身伤害的事故进行了分析。其事故发生率极低,只有0.09(每年每一百万车辆每公里发生的事故次数),最高的事发率是在陡坡的年平均日通车量(AADT)低于1500的隧道中。挪威海底隧道中只发生过3起火灾事故,低于交通事故率10%,而这项研究只包括了17条隧道中发生的19起事故。 | HENNING Jan Eirik MELBY Karl фVSTEDAL Erik AMUNDSEN Finn H RANES Guro | 2007 | 岩石力学与工程学报2007，26，11： | 2 |
| 6 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 7 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 8 | Moral Identity and Judgments of Charitable Behaviors 显示文摘 | Americus H Reed Karl Aquino Eric Levy | 2007 | Joumal of Marketing2007，71，1： | 1 |
| 9 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 10 | Development of a quantitative method for the analysis of tobacco-specific nitrosa- mines in mainstream cigarette smoke using isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry 显示文摘 | Karl A W Nancy H F Fossett J E | 2005 | Analytical Chemistry2005，77，： | 1 |
| 11 | Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging显示文摘 | Augustinaek JC Karl H Kristen EH | 2010 | Front human neurosci2010，4，42： | 1 |
| 12 | Aspects of coal properties and constitution important for gasification 显示文摘 | Karl H Heek V and Mulen H J | 1985 | Fuel1985，64，10： | 1 |
| 13 | 3D visualization of tomographic volume data using the generalized voxel model显示文摘 | Karl H H Michale B Andreas P | 1990 | The Visual Computer1990，6，1： | 1 |
| 14 | Effects of Salinity on endogenous ABA, IAA, JA, and SA in Iris hexagona显示文摘 | Wang Y Y Mopper S Karl H | 2001 | JChem Ecology2001，27，2： | 1 |
| 15 | Spatial analysis of Honolulu motor vehicle crashes: I spatial patterns 显示文摘 | Ned Levine Karl E Kim Lawrence H Nitz | 1996 | Accident Analysis and Prevention1996，27，5： | 1 |
| 16 | Study of the neu- roprotective effects of memantine in patients with mild to moderate ischemic stroke显示文摘 | Karl H Salamzadeh J Beladimoghadam N | 2014 | Iran J Pharm Res2014，13，： | 1 |
| 17 | 4-(β-D-glucopyranosyloxy)benzoic acid, a characteristic phenolic constituent of the Apiaceae 显示文摘 | Uwe D Karl H | 1984 | Phytochemistry1984，23，8： | 1 |
| 18 | Developmental outcome and psychosocial adjustment in children after surgery for congenital heart disease during infancy 显示文摘 | Katja H Karl - Otto D Herman K | 2007 | SRIP2007，25，2： | 1 |
| 19 | Property tax incidence in a multijurisdictional neoclassical model显示文摘 | Case Karl E Grant J H | 1991 | Public Finance Quarterly1991，19，： | 1 |
| 20 | Phenolic compounds from the rhizomes of Dioscorea bulbifera 显示文摘 | Liu H Karl W K T Chou G X | 2011 | Chem Biodiv2011，8，： | 1 |
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