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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Functional magnetic resonance imaging and the brain: A brief review显示文摘Functional magnetic resonance imaging(fMRI) is em-ployed in many behavior analysis studies, with blood oxygen level dependent-(BOLD-) contrast imaging being the main method used to generate images. The use of BOLD-contrast imaging in f MRI has been refined over the years, for example, the inclusion of a spin echo pulse and increased magnetic strength were shown to produce better recorded images. Taking careful precautions to control variables during measurement, comparisons between different specimen groups can be illustrated by f MRI imaging using both quantitative and qualitative methods. Differences have been observed in comparisons of active and resting, developing and aging, and defective and damaged brains in various studies. However, cognitive studies using f MRI still face a number of challenges in interpretation that can only be overcome by imaging large numbers of samples. Furthermore, f MRI studies of brain cancer, lesions and other brain pathologies of both humans and animals are still to be explored. | Maggie SM Chow Sharon L Wu Sarah E Webb Katie Gluskin DT Yew | 2017 | World Journal of Radiology2017，9，1： | 4 |
| 3 | SAIL: A 3D rehabilitation system to improve ann function following stroke 显示文摘 | Katie L Zhonglun Cai Tong Meng | 2011 | Progress In Neurology And Psychiatry2011，15，2： | 1 |
| 4 | One hundred years of solitude:integrating single-strain inoculations with community perspectives in the legume-rhizobium symbiosis显示文摘 | Friesen Maren L Katy D. Heath | | 0，，01： | 1 |
| 5 | Phylogenetie analysis of en- terovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia 显示文摘 | Peter M Katie L David P | 2001 | J Virol2001，75，16： | 1 |
| 6 | Mammary Gland Immunity and Mastitis Susceptibility显示文摘 | Lorraine M Sordillo Katie L S | 2002 | Journal of Mammary Gland Biology and Neoplasia2002，，7： | 1 |
| 7 | Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart显示文摘The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases. | Anastasios Lymperopoulos Shelby L Wertz Celina M Pollard Victoria L Desimine Jennifer Maning Katie A McCrink | 2019 | World Journal of Cardiology2019，11，2： | 1 |
| 8 | Phylogenetic Analysis of Entero - virus 71 Strains Isolated During Linked Epidemics in Malaysia, Singa - pore, and Western Australia显示文摘 | Peterm Katie L David P | 2001 | J Virol2001，75，12： | 1 |
| 9 | Ototoxicity of the three xylene isomers in the rat显示文摘 | Katy M Robert L Pierre C | 2006 | Neurotoxicol Teratol2006，28，： | 1 |
| 10 | Neutrophil enhance- ment of Pseudomonas aeruginosa biofilm development : human F-ae- tin and DNA as targets for therapy显示文摘 | QUINN M P ROBERT L Y KATIE R P | 2009 | Journal of Medical Microbi- ology2009，58，： | 1 |
| 11 | The effectiveness of the serum surfactant protein D(Sp-D) level to indicate lung injury in pulmonary embolism显示文摘 | Kati C Alaeam H Duran L | 2014 | Clin Lab2014，60，9： | 1 |
| 12 | Angiotensin | con- verting enzyme inhibitory properties of whey protein di- gests: concentration and characterization of active pep- tides显示文摘 | ANNE P L PAIVI K KATI P | 2000 | J Dairy Res2000，67，： | 1 |
| 13 | Ergosterol content in various fungal species and biocontaminated building materials显示文摘 | PASANEN A L KATI Y P PASANEN P | 1999 | Appl Envi Microb1999，65，1： | 1 |
| 14 | Higher-tier laboratory methods for assessing the aquatic toxicity of pesticides 显示文摘 | Alistair B A B Colin D B Katie L B | 2002 | Pest Management Science2002，58，7： | 1 |
| 15 | Mechanisms of quinolone resistance in Escherichia coli and Salmonella:recent developments显示文摘 | Katie L Hopkins Robert H | 2005 | International Journal of Antimicrobiial Agents2005，25，5： | 1 |
| 16 | Differentiation of tomato yellow leaf cur virus and to- mato yellow leaf curl Sardinia virus using real-time TaqMan PCR 显示文摘 | Papayiannis L C Iacovides T A Katis N I | 2010 | Journal of Virological Methods2010，165，： | 1 |
| 17 | The effect of a structured behavioral intervention on poorly controlled diabetes:A randomized controlled trial显示文摘 | Katie W Beverly E A Yishan L | 2011 | Archives of Internal Medicine2011，171，22： | 1 |
| 18 | GIS based visualization of rural landscapes:defining sufficient realism for environmental decisionmaking显示文摘 | Katy A Andrew L | 2003 | Landscape and Urban planning2003，，65： | 1 |
| 19 | Effects of dietary n-6and n-3fatty acids and vitamin E on the immune response of healthy geriatric dogs显示文摘 | Jean A Katie A Joseph L | 2003 | American Journal of Veterinary Research2003，64，6： | 1 |
| 20 | A high-fat, high-fructose diet accelerates nutrient absorption and impairs net hepatic glucose uptake in response to a mixed meal in par- tially panereatectomized dogs 显示文摘 | Katie C C Guillaume K Margaret L | 2011 | J Nutr2011，141，9： | 1 |
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