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| 1 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 2 | Bulk parameterization of the air-sea exchange of heat and water vapor including the molecular constraints at the interface 显示文摘 | Liu W T Katsaros K B Businger J A | 1979 | J Atmos Sci1979，36，： | 1 |
| 3 | Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma显示文摘 | Luo LY Katsaros D Scorilas A | 2001 | Clin Cancer Res2001，7，9： | 1 |
| 4 | Bulk Parameterization of Air-sea Exchanges of Heat and Water Vapor Including the Molecular Constraints at the Interface 显示文摘 | LIU W T KATSAROS K B BUSINGER J B | 1979 | Journal of the Atmospheric Science1979，36，9： | 1 |
| 5 | Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma显示文摘 | Luo LY Katsaros D Scorilas A | | 0，，08： | 1 |
| 6 | The serum concen- tration of human kallikrein 10 represents a novel biomark- er for ovarian cancer diagnosis and prognosis 显示文摘 | Luo LY Katsaros D Scorilas A | 2003 | Cancer Res2003，63，4： | 1 |
| 7 | Optimal sites for ortho- dontic mini-implant placement assessed by cone beam com- puted tomography显示文摘 | Fayed MM Pazera P Katsaros C | 2010 | Angle Orthod2010，80，5： | 1 |
| 8 | Immunofluorometric quantitation and histochemical localiaation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker显示文摘 | Hoffman BR Katsaros D Scorilas A | 2002 | Br J Cancer2002，87，7： | 1 |
| 9 | Aberrant promoter methylation of multiple genes in malignant ovarian tμmol/Lors and in ovarian tμmol/Lors with low malignant potential显示文摘 | Wiley A Katsaros D Chen H | 2006 | Cancer2006，107，2： | 1 |
| 10 | A unified directional spectrum for long and shott wind-driven waves显示文摘 | Elfouhaily T Chapron B Katsaros K | 1997 | J Geophys Res1997，102，15： | 1 |
| 11 | Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer显示文摘 | Zhang L Conejo-Garcia JR Katsaros D | 2003 | N Engl J Med2003，348，： | 1 |
| 12 | Generalized Hirsch h-index for disclosing latent facts in citation networks显示文摘 | Sidiropoulos A Katsaros D Manolopoulos Y | 2007 | Scientometrics2007，72，2： | 1 |
| 13 | The lateral upper arm flap : Anatomy and clinical applications 显示文摘 | Katsaros J Schusterman M Beppu M | 1984 | Ann Plast Surg1984，12，6： | 1 |
| 14 | The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis显示文摘 | Luo LY Katsaros D Scorilas A | | 0，，04： | 1 |
| 15 | Architectural requirements for cloud computing systems: an enterprise cloud approach显示文摘 | RIMAL B P JUKAN A KATSAROS D | 2011 | Journal of Grid Computing2011，9，1： | 1 |
| 16 | Probabilistic model checking for the quantification of DoS security threats显示文摘 | Stylianos Basagiannis Panagiotis Katsaros Andrew Pombortsis Nikolaos Alexiou | 2009 | Computers & Security2009，28，5： | 1 |
| 17 | B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression显示文摘 | Simon 1 Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 18 | CTDNA interaction studies of a platinum (Ⅱ) complex,PtCl2 (NN) (NN= 4,7-dimethyl-1,10-phenanthroline),using different instrumental methods显示文摘 | PSOMAS E K EFTHIMIADOV N KATSAROS A | 2007 | Inorg Chim Acta2007，360，： | 1 |
| 19 | The lateral upper arm flap:anatomy and clinical applications显示文摘 | Katsaros J Schusterman M Beppu M | 1984 | Ann Plast Surg1984，12，6： | 1 |
| 20 | Quantum Transport in GaN/AIN Double- Barrier Heterostructure Nanowires 显示文摘 | Songmuang R Katsaros G Monroy E | 2010 | Nano Lett2010，10，： | 1 |
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