|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 2 | Technological innovation in low- dose SIMOX wafers fabricated by an internal thermal oxidation (ITOX) process 显示文摘 | Matsummura A Hamaguchi I Kawamura K | 2003 | Microelectronic Engineering2003，66，： | 2 |
| 3 | Biogenic and anthropogenic organic compounds in rain and snow samples collected in Southern California显示文摘 | Kawamura K Kaplan I R | 1986 | Atmospheric Environment1986，20，： | 1 |
| 4 | A high dietary in take of sodiumglutamate as flavoring causes gross changes in retinahnor- phology and function显示文摘 | Ohguro H Kawamura H Maruyama I | 2002 | Exp Eye Res2002，75，3： | 1 |
| 5 | Capillary gas chromatography determination of volatile organic acids in rain and fog samples 显示文摘 | Kawamura K Kaplan R I | 1984 | Analysis Chemistry1984，，56： | 1 |
| 6 | Immunohistochemical detection of proliferating cell nucler antigen(PCNA)/cyclin in human prostate adenocarcinoma显示文摘 | Nemoto R Kawamura H Miyakawa I | 1993 | J Urol1993，149，： | 1 |
| 7 | Pre- or post-treatment with hepatocyte growth factor prevents glycerol-induce acute renal failure显示文摘 | Nagano T Mori-Kudo I Kawamura T | 2004 | Ren Fail2004，26，1： | 1 |
| 8 | Intravenous injection of oligodeoxynucleotides to the NF-kappa B binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice显示文摘 | Kawamura I Morishita R Tsujimoto S | 2001 | Gene Ther2001，8，12： | 1 |
| 9 | Holographic writing of micro-gratings and nanostructures on amorphous SiO2 by near infrared femtosecond pulses 显示文摘 | HOSONO H KAWAMURA K I MATSUISHI S | 2002 | Nuclear Instruments and Methods in Physics Research B2002，191，： | 1 |
| 10 | Involvement of AIM2 in inflammasome activation in macrophages infected with listeria monocytogenes显示文摘 | Tsuchiya K Hara H Kawamura I | 2010 | J Immunol2010，185，2： | 1 |
| 11 | Clinical study of therapeutic angiogenesis by autologous peripheral blood stem cell (PBSC) transplantation in 92 patients with critically ischemic limbs显示文摘 | Kawamura A Horie T Tsuda I | 2006 | J Artif Organs2006，9，4： | 1 |
| 12 | Ice core records of polycyclic aromatic hydrocarbons over the past 400 years显示文摘 | Kawamura K Suzuki I | 1994 | Naturwissenschaften1994，81，： | 1 |
| 13 | Preventing the transmission of methicillin-resistant Staphylococcus aureus at a tertiary care cancer center in Japan:quality improvement report显示文摘 | Kawamura I Ohmagari N Noda S | 2013 | Am J Infect Control2013，41，11： | 1 |
| 14 | Effect of insulin resistance on the endothelial vasomotor function of the coronary artery of nondiabetic patients 显示文摘 | Kawamura I Satoh K | 1999 | Jpn Circ J1999，63，8： | 1 |
| 15 | Effect of Ni substitution on the microwave dielectric properties of cordierite 显示文摘 | TERADA M KAWAMURA K KAGOMIYA I | 2007 | J Eur Ceram Soc2007，27，89： | 1 |
| 16 | Convective mixing of air at four polar sites显示文摘 | Kawamura K Jeffrey P Severinghaus S I | 2006 | Earth and Planetary Science Letters2006，，244： | 1 |
| 17 | 显示文摘 | Kawamura Y Kato H I noue A | 1997 | Int J Powder Metallurgy1997，33，： | 1 |
| 18 | Prevention of limb ampution in patients with limbs ulcers by autologous peripheral blood mononuclear cell implantation显示文摘 | Kawamura A Horie T Tsuda I | 2005 | Ther Apher Dial2005，9，1： | 1 |
| 19 | Biogenic and anthropogenic organic compounds in rain and snow samples collected in southern California显示文摘 | Kawamura K Kaplan I R | 1986 | Atmos Environ1986，20，1： | 1 |
| 20 | Motor exhaust emissions as a primary source for dicarboxylic acids in Los Angeles ambient air显示文摘 | Kawamura K Kaplan I R | 1987 | Environmental Science and Technology1987，21，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员