|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Terlipressin and hepatorenal syndrome: What is important for nephrologists and hepatologists显示文摘Hepatorenal syndrome (HRS) is a reversible form of functional renal failure that occurs with advanced hepatic cirrhosis and liver failure. Despite mounting research in HRS, its etiology and medical therapy has not been resolved. HRS encompasses 2 distinct types. Type 1 is characterized by the rapid development of renal failure that occurs within 2 wk and involves a doubling of initial serum creatinine. Type 2 has a more insidious onset and is often associated with ascites. Animal studies have shown that both forms, in particular type 1 HRS, are often precipitated by bacterial infections and cir-culatory changes. The prognosis for HRS remains very poor. Type 1 and 2 both have an expected survival time of 2 wk and 6 mo, respectively. Progression of liver cir-rhosis and the resultant portal hypertension leads to the pooling of blood in the splanchnic vascular bed. The ensuing hyperdynamic circulation causes an ineffective circulatory volume which subsequently activates neuro-hormonal systems. Primarily the sympathetic nervoussystem and the renin angiotensin system are activated, which, in the early stages of HRS, maintain adequate circulation. Both advanced cirrhosis and prolonged ac-tivation of neurohormonal mechanisms result in fatal complications. Locally produced nitric oxide may have the potential to induce a deleterious vasodilatory effect on the splanchnic circulation. Currently medical therapy is aimed at reducing splanchnic vasodilation to resolve the ineffective circulation and maintain good renal per-fusion pressure. Terlipressin, a vasopressin analogue, has shown potential benefit in the treatment of HRS. It prolongs both survival time and has the ability to re-verse HRS in the majority of patients. In this review we aim to focus on the pathogenesis of HRS and its treatment with terlipressin vs other drugs. | Ahmed A Magan Atif A Khalil Mohamed H Ahmed | 2010 | World Journal of Gastroenterology2010，16，41： | 11 |
| 2 | 广东清远早、晚稻稻田甲烷排放的观测研究显示文摘分析了2003、2004年广东省清远市郊区早、晚稻稻田甲烷(CH4)的排放通量,结果表明广东清远早、晚稻稻田CH4排放通量的几何平均值2003年为4.38mg·m-2·h-1和6.09mg·m-2·h-1;2004年为5.17mg·m-2·h-1和8.3mg·m-2·h-1,土壤有机质含量是造成2003和2004年CH4排放差异的原因之一。水稻品种的不同,CH4排放通量也有所不同,实验表明,水稻品种“七丝尖”的排放通量比品种“金优99”高1.08mg·m-2·h-1,产量却只有64%。此外,与相关的测量结果进行初步比较。 | 许黎 任万辉 杨宁 王天龙 刘锦銮 M A K Khalil R A Rasmussen M J Shearer | 2007 | 气象2007，33，3： | 3 |
| 3 | Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cor injury: A case series显示文摘Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO. | Pamela D Moore Ashraf S Gorgey Rodney C Wade Refka E Khalil Timothy D Lavis Rehan Khan Robert A Adler | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 4 | 柴油乳化液喷雾闪急沸腾与微爆现象的激光阴影试验研究(英文)显示文摘在常压定容室内,应用ND:YAG激光阴影法、高分辨率CCD照相机和粒径分析软件,对不同含水量的柴油乳化液雾油滴的闪急沸腾与微爆现象以及油滴粒径分布进行了试验测量与变参数对比分析,探讨了在130℃温度条件下,乳化油含水量对乳化油喷雾液滴闪急沸腾和微爆的影响,揭示了微爆效应在喷雾雾化和液滴碎化中的作用机理。试验结果表明,包覆于油中的水相颗粒受热闪急沸腾所形成的高压蒸气团冲破无水边界层是导致油滴发生微爆和进一步破碎分裂的首要原因;微爆现象随乳化油含水量的增高而趋强;喷雾索特平均直径(SMD)的细化率随乳化油含水量和喷雾贯穿距的增加而增大,且乳化油含水量对喷雾SMD细化率的影响程度也随喷雾贯穿距的增加更加显著。 | MEDHAT Elkelawy 张煜盛 Alm El-Din Hagar 余敬周 El Zahaby A M El Shenawy E A Khalil A | 2009 | 内燃机学报2009，27，4： | 3 |
| 5 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 6 | Breaking wheat yield barriers requires integrated efforts in developing countries显示文摘Most yield progress obtained through the so called 'Green Revolution', particularly in the irrigated areas of Asia, has reached a limit, and major resistance genes are quickly overcome by the appearance of new strains of disease causing organisms.New plant stresses due to a changing environment are difficult to breed for as quickly as the changes occur.There is consequently a continual need for new research programs and breeding strategies aimed at improving yield potential, abiotic stress tolerance and resistance to new, major pests and diseases.Recent advances in plant breeding encompass novel methods of expanding genetic variability and selecting for recombinants, including the development of synthetic hexaploid, hybrid and transgenic wheats.In addition, the use of molecular approaches such as quantitative trait locus(QTL) and association mapping may increase the possibility of directly selecting positive chromosomal regions linked with natural variation for grain yield and stress resistance.The present article reviews the potential contribution of these new approaches and tools to the improvement of wheat yield in farmer's fields, with a special emphasis on the Asian countries, which are major wheat producers, and contain the highest concentration of resource-poor wheat farmers. | Saeed Rauf Maria Zaharieva Marilyn L Warburton ZHANG Ping-zhi Abdullah M AL-Sadi Farghama Khalil Marcin Kozak Sultan A Tariq | 2015 | Journal of Integrative Agriculture2015，14，8： | 2 |
| 7 | A SiC14-ZnC12 induced general, mild and efficient one-pot, three- component synthesis of fl-amido ketone libraries 显示文摘 | Tarek A Salama Saad S Elmorsy Abdel-Galel M Khalil | 2007 | Tetrahedmn Letters2007，48，： | 1 |
| 8 | Isolation,identification and toxicity of saponin from different legumes显示文摘 | Khalil A H El-Adawy T A | 1994 | Food chemistry1994，50，： | 1 |
| 9 | Synthesis and application of some 1 - alkylidene -substituted heteroeycles as bactericides, funjicides, and bioregulator 显示文摘 | KHALIL Z H YANNI A S KHALAF A A | 1988 | J Bull Chem Soc Jpn1988，62，： | 1 |
| 10 | Quantitative PCR assay using sputum samples for rapid diagnosis of pneumococcal pneumonia in adult emergency department patients显示文摘 | Yang S Lin S Khalil A | 2005 | J Clin Microbiol2005，43，： | 1 |
| 11 | Influence of a lignin based admixture on the hydration of portland cements显示文摘 | KHALIL S M WARD M A | 1973 | Cem Concr Res1973，3，6： | 1 |
| 12 | The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas显示文摘 | Murata T Nakagawa K Khalil A | 1996 | Lab Invest1996，74，4： | 1 |
| 13 | The relation between expressio of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas显示文摘 | Murata T Nakagawa K Khalil A | 1996 | Lab Invest1996，74，4： | 1 |
| 14 | Oxidized - LDL inducemorphological c hanges and increase stiffiiess of endothelial cells显示文摘 | Chouinard J A Grenier G Khalil A | 2008 | Exp Cell Res2008，314，16： | 1 |
| 15 | MicroRNA profile analysis of human prostate canc- ers 显示文摘 | Tong A W Fulgham P Jay C Chen P Khalil I Liu S | 2009 | Cancer Gene Ther2009，16，： | 1 |
| 16 | Impairment of the ABCA1 and SRBI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease显示文摘 | Khalil A Berrougui H Pawelec G | | 0，，01： | 1 |
| 17 | Role of MDCT in identification of the bleeding site and the vessels causing hemoptysis显示文摘 | Khalil A Fartoukh M Tassart M | 2007 | AJR Am J Roentgenol2007，188，2： | 1 |
| 18 | Quadratic-type Lyapunov functions for singularly perturbed systems显示文摘 | Saberi A Khalil H | 1984 | IEEE Trans on Automatic Control1984，29，6： | 1 |
| 19 | Utility of CT scan for the diagnosis of chest wall tuberculosis显示文摘 | Khalil A Le Breton C Tassart M | 1999 | Eur Radiol1999，9，8： | 1 |
| 20 | Cisplatin plus vinorelbine (PVn) as a salvage regiment for refractory breast cancer显示文摘 | Chehal A Taher A Khalil M | 2004 | Breast2004，13，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员