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| 1 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 2 | Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference显示文摘Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. | Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen | 2006 | Journal of Geriatric Cardiology2006，3，2： | 2 |
| 3 | Incidence of atherosclerotic cardiovascular events in patients with chronic uremia: cpidemiologie studies in He-de France显示文摘 | Jungers P Nguyen Khoa T Massy ZA | 1998 | Nephrolgie1998，19，8： | 1 |
| 4 | Incidengce and risk factor of atheroselerotic cardiovascular accidents in predialysis chronic renal failure patients :a prospective study 显示文摘 | Jungers P Massy ZA Nguyen Khoa T | 1997 | Nephrol Dial Transplant1997，12，12： | 1 |
| 5 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure 显示文摘 | Witko-Sarsat V Friedlander M Nguyen Khoa T | 1998 | Immunol1998，161，： | 1 |
| 6 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure显示文摘 | Witko-Sarsat V Friedlander M Nguyen Khoa T | 1998 | J Immunol1998，161，5： | 1 |
| 7 | Incidence and risk factors of atherosclerotic cardiovascular accidents in predialysis chronic renal failure patients: a prospective study显示文摘 | JUNGERS P MASSY Z A KHOA T N | 1997 | Nephrol Dial Transplant1997，12，2： | 1 |
| 8 | Elevated circulating levels of interleukin-6 in patients with chronic renal failure显示文摘 | Witko-Sarsat V Friendlander M Nguyen Khoa T | 1998 | Immunol1998，161，： | 1 |
| 9 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure显示文摘 | Witko-Sarsat V Friedlander M l'qguyen Khoa T | 1998 | J Immunol1998，161，5： | 1 |
| 10 | Potential role of HOXD9 insynoviocyte proliferation 显示文摘 | Khoa ND Nakazawa M Hasunuma T | 2001 | Arthritis Rheum2001，44，5： | 1 |
| 11 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure 显示文摘 | Witko-Sarsat V Friedlander M Nguyen Khoa T | 1998 | J Immunol1998，161，5： | 1 |
| 12 | 查看详情显示文摘 | Yoo D H Cuong T V Luan V H Khoa N T Kim E J Hur S H Hahn S H | | 0，，12： | 1 |
| 13 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure显示文摘 | Witko-Sarsat V Friedlander M Nguyen Khoa T | 1998 | J Immunol1998，161，5： | 1 |
| 14 | Application of wavelet and neural network to long-term load forecasting显示文摘 | KHOA T Q D PHUONG L M BINH P T T | 2004 | IEEE International Conference on Power System Technology2004，1，： | 1 |
| 15 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure显示文摘 | Witko-Sarsat V Friedlander M Khoa T N | 1998 | J Immunol1998，161，1： | 1 |
| 16 | Advanced oxidation protein products as novel mediators ofinflammation and monocyte activation in chronic renal failure显示文摘 | Witko Sarsat V Friedlander M Nguyen Khoa T | 1998 | J lmmunol1998，161，： | 1 |
| 17 | Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure显示文摘 | Witko-Sarsat V Friedlander M Nguyen Khoa T | 1998 | J Immunol1998，161，5： | 1 |
| 18 | Polymorphism of interleukin-10 promoter and tumor necrosis factor receptor Ⅱ in Vietnamese patients with systemic lupus erythematosus显示文摘 | Khoa PD Sugiyama T Yokochi T | | 0，，： | 1 |
| 19 | Potential role of HOXD9 in synoviocyte proliferation显示文摘 | Khoa ND Nakazawa M Hasunuma T | 2001 | Arhritis Rheum2001，44，5： | 1 |
| 20 | Early prediction of IgA nephropathy progression:proteinuriaand AOPP are strong prognostic markers显示文摘 | DESCAMPS LATSCHA B WITKO SARSAT V NGUYEN KHOA T | 2004 | Kidney Int2004，66，4： | 1 |
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