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| 1 | Th17 cells and their associated cytokines in liver diseases显示文摘T helper 17(Th17)cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune disease.The functions of Th17 cells are mediated via the production of several cytokines including interleukin(IL)-17 and IL-22.Recent studies show that the frequency of IL-171 cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease,viral hepatitis and hepatocellular carcinoma.IL-17 receptor is expressed virtually on all types of liver cells,while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the liver.IL-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines,while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation. | Fouad Lafdil Andrew M Miller Sung Hwan Ki Bin Gao | 2010 | Cellular & Molecular Immunology2010，7，4： | 29 |
| 2 | 脉搏波传导速度预测青年人血压进展与高血压发生显示文摘该研究旨在评估脉搏波传导速度(pulse wave velocity,PWV)是否能够预测青年人血压进展及高血压的发生,并探讨除传统心血管病危险因素外,PWV是否可改善高血压发生的风险预测。Koivistoinen等于2007年及2011年分别测量1449例芬兰成人(年龄30~45岁)的收缩压及舒张压水平。此外,于2007年还测定了其PWV及其他心血管病危险因素。 | Koivistoinen T Lyytik?inen LP Aatola H Luukkaala T Juonala M Viikari J Lehtim?ki T Raitakari OT K?h?nen M Hutri-K?h?nen N 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，1： | 12 |
| 3 | Differential roles of EPS8 in carcinogenesis:Loss of protein expression in a subset of colorectal carcinoma and adenoma显示文摘AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells.METHODS:We studied 8 colon cancer cell lines and 58 colorectal tumors(19 adenomas and 39 carcinomas).We performed expression microarray analysis of colon cancer cell lines followed by loss of heterozygosity(LOH)analysis and immunohistochemistry for EPS8 expression in colon tumors.Subsequently,we performed mutation analysis by direct sequencing and methylation analysis by bisulfite sequencing and methylation-specific polymerase chain reaction assays.RESULTS:Expression microarray analysis of colon cancer cell lines showed overexpression of EPS8 transcript in all lines but RKO.Genome wide loss of heterozygosity(LOH) analysis of colon tumors,showed considerable LOH at the EPS8 gene locus.Immunohistochemically,EPS8 was constitutively expressed in normal colonic mucosa with a dot-like supranuclear localization with accentuation at the luminal surface supporting its proposed role in epithelial maturation.Nineteen colon tumors(4 adenoma,15 carcinoma) out of 51(37%) showed strikingly tumor specific EPS8 protein loss.Of the remaining tumors,5/51(2 adenoma,and 3 carcinoma,10%) showed marked overexpression,while 27/51 tumors(53%) showed retained expression.Mutation analysis revealed a missense mutation(c.794C>T,p.R265C) in exon 8 in RKO.The EPS8 promoter was also methylated in RKO,but there was no significant methylation in other cell lines or carcinoma specimens.CONCLUSION:The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers,a finding which could have applications in diagnosis and treatment. | Wael M Abdel-Rahman Salla Ruosaari Sakari Knuutila Pivi Peltomki | 2012 | World Journal of Gastroenterology2012，18，29： | 5 |
| 4 | Effect of polyethylene glycol on electrochemically deposited trivalent chromium layers显示文摘The structural characteristics of the trivalent chromium deposits and their interfacial behavior in the plating solution with and without polyethylene glycol molecules were observed by using various electrochemical methods such as cyclic voltammetry,open circuit potential transition,electrochemical impedance spectroscopy,scanning electron microscopy and X-ray photoelectron spectrometry.It is shown that the polyethylene glycol molecules make the reductive current density lower in the trivalent chromium plating system and promote a hydrogen evolution reaction through their adsorption on the electrode surface.And the trivalent chromium layer formed from the polyethylene glycol-containing solution has somewhat higher density of cracks on its surface and results in a lower film resistance,lower polarization resistance,and higher capacitance in a corrosive atmosphere.It is also revealed that the formation of chromium carbide layer is facilitated in the presence of polyethylene glycol,which means easier electrochemical codeposition of chromium and carbon,not single chromium deposition. | Joo-Yul LEE Man KI M Sik-Chol KWON | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 5 |
| 5 | New means to monitor the effect of glucocorticoid therapy in children显示文摘AIM:To study the individual effects of glucocorticoid (GC) therapy on the state ofimmune activation in patient serum.METHODS:We developed a novel assay in which the effect of corticosteroid-treated patient serum on healthy donor peripheral blood mononuclear cells (target cells) was studied,with a panel of markers for effector [interferon (IFN)γ and interleukin (IL)-5] and regulatory T cells (FOXP3 and glucocorticoid-induced tumor necrosis factor receptor,GITR).The study group comprised 19 children with inflammatory bowel disease.The individual effect of patient serum on target cells was analyzed prior to GC therapy and 2 wk later.RESULTS:The effect of GC therapy mediated by patient serum was seen as a decrease in the target cells expression of regulatory T-cell-related markers GITR (median suppression 24%,range of suppression 1%-63%,in 2 cases increase of 6% and 77%,P < 0.01 for mitogen-activated target cells) and FOXP3 (median suppression 33%,range of suppression 0%-79%,in one case an increase of 173%,P < 0.05 for resting cells),and secretion of IFNγ [from a mean of 87 700 pg/mL (SD 33 900 pg/mL) to 60 900 pg/mL (SD 44 200 pg/mL) in mitogen-activated target cells,13 of the cases showed a decrease,P < 0.01].The total or weight-related prednisolone dose did not correlate with the patient-seruminduced changes in the target cell markers.CONCLUSION:GC response could be monitored at an individual level by studying the effect of patient serum on signaling pathways of target immune cells. | Hanne Rintamki Harri M Salo Outi Vaarala Kaija-Leena Kolho | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 6 | European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease显示文摘 | S. Husby S. Koletzko I.R. Korponay-Szabó M.L. Mearin A. Phillips R. Shamir R. Troncone K. Giersiepen D. Branski C. Catassi M. Lelgeman M. M?ki C. Ribes-Koninckx A. Ventura K.P. Zimmer | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，1： | 2 |
| 7 | Solution structure of the epithelial cadherin domain responsible for selective cell adhesion显示文摘 | Overduin M Harvey TS Bagby S Tong KI Yau P Takeichi M Ikura M | | 0，，： | 2 |
| 8 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 9 | European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease显示文摘 | S. Husby S. Koletzko I.R. Korponay-Szabó M.L. Mearin A. Phillips R. Shamir R. Troncone K. Giersiepen D. Branski C. Catassi M. Lelgeman M. M?ki C. Ribes-Koninckx A. Ventura K.P. Zimmer | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，1： | 2 |
| 10 | Immuno- logenicity of human amniotic epithelial cells after transplantation into volunteers 显示文摘 | Aide CA Adinolfi M Welsh KI | 1981 | Lancet1981，2，： | 1 |
| 11 | HepatoceUular o11- eofetal protein,glypiean 3 is a sensitive marker for alpha - feto- protein - producing gastric carcinoma 显示文摘 | Hishinuma M Ohashi KI Yamauehi N et 81 | 2006 | Histopathalogy2006，49，5： | 1 |
| 12 | A feasible method for fractional snow cover mapping in boreal zone based on a reflectance model显示文摘 | SARI J Mets(a)m(a)ki SAKU T Anttila HUTTUNEN J Markus 2005 | 2005 | Remote Sensing of Environment2005，95，： | 1 |
| 13 | A new scaling method for component maps of gas turbine using system identification 显示文摘 | KONG C KI J KANG M | 2003 | Journal of Engineering for Gas Turbines and Power2003，125，： | 1 |
| 14 | The association of metabolic syndrome with adipose tissue hormones and insulin resistance in patients with COPD without co- morbidities显示文摘 | Minas M Kostikas K Papaioannou AI Mystridou P Karetsi E Georgoulias P Liakos N Pournaras S Gourgoulianis KI | 2011 | COPD2011，8，6： | 1 |
| 15 | Correlation between FDG uptake by PET/CT and the expressions of glucose transport- er type I and hexokinase II in cervical cancer显示文摘 | Tong S Y Lee J M Ki K D | 2012 | Internation- al Journal of Gynecological Cancer2012，22，4： | 1 |
| 16 | Probiotics in primary prevention of atopic disease:a randomised placebo-controlled trial显示文摘 | KALLIOMKI M SALMINEN S ARVILOMMI H | 2001 | The Lancet2001，357，9262： | 1 |
| 17 | Numerical and experimental identification of vibration convection chamber of fluid power boiler 显示文摘 | PADUCHOWICZ M GORSKI A CZMOCHOWS- KI J | 2012 | Journal of Vibroengineering2012，14，1： | 1 |
| 18 | Hans Berger (1873-1941)-the history of electroencephalography显示文摘 | Tudor M Tudor L Tudor KI | 2005 | Acta Med Croatiea2005，59，4： | 1 |
| 19 | Triple-negative breastcancer:clinical features and patterns of recurrence显示文摘 | Dent R Trudeau M Pritchard KI | 2007 | Clin CancerRes2007，13，15： | 1 |
| 20 | Delayed ischemic hyperintensity on T1-weighted MRI in the caudoputamen and cerebral cortex of humans after spectacular shrinking deficit显示文摘 | Fujioka M Taoka T Hiramatsu KI | 1999 | Stroke1999，30，5： | 1 |
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