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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | A new mechanism for IL-5 dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5显示文摘 | Al-Qaoud KM Pearlman E Hartung T | | Int Immunol0，12，6： | 1 |
| 3 | Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis显示文摘 | Ho Km Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
| 4 | Efficacy of letrozole in the treatment of recurrent platinum-and taxane-resistant high-grade cancer of the ovary or peritoneum 显示文摘 | Ramirez PT Schmeler KM Milam MR e t al | 2008 | Gynecol Oncol2008，110，1： | 1 |
| 5 | The AGE/RAGE/ NF-kappaB pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT) 显示文摘 | Haslbeck KM Schleicher E Bierhaus A | 2005 | Exp Clin Endocfinol Diabetes2005，113，5： | 1 |
| 6 | Rheumatic mitral valve disease;current sulcal status显示文摘 | Zakkar M Amirak E Chan KM | 2009 | Pkog Cardiovasc Dis2009，51，6： | 1 |
| 7 | Placebo and opioid analgesia-imaging a shared neuronal network 显示文摘 | Petrovic P Kalso E Petersson KM | 2002 | Science2002，295，5560： | 1 |
| 8 | Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis 显示文摘 | Bjornsson E Boberg KM Cullen S | 2002 | Gut2002，51，5： | 1 |
| 9 | Identification of soluble APO-1 in supematants of human B-and T-Cell lines and increased serum levels in B-and T-cell leukemia 显示文摘 | Knipping E Debatin KM Striker K | 1995 | Blood1995，85，6： | 1 |
| 10 | Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection:a meta-analysis显示文摘 | Ho KM Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
| 11 | Observer agreement in evaluation coronary angiograms显示文摘 | Detre KM Wright E Murphy ML | 1975 | Circulation1975，52，15： | 1 |
| 12 | Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm显示文摘 | Banin E Brady KM Greenberg EP | 2006 | Appl Environ Microbiol2006，72，： | 1 |
| 13 | Perceived stress and coping resource availability as predictors of life satesfaction in young, middle-aged, and older adults 显示文摘 | Hamarat E Thompson D Zabrucky KM | 2001 | Exp Aging Res2001，27，2： | 1 |
| 14 | Intravaginal highdose-rate brachytherapy for Stage IB(FIGO Grade 1,2)endometrial cancer显示文摘 | Alektiar KM McKee A Venkatraman E | 2002 | Int J Radiat Oncol Biol Phys2002，53，3： | 1 |
| 15 | The association of allergic symptoms with sensitization to inhalant allergens in childhood显示文摘 | Govaere E Van Gysel D Verhamme KM | 2009 | Pediatr Allergy Immunol2009，20，5： | 1 |
| 16 | Cureumin induces Nrf2 nucle- ar translocation and prevents glomerular hypertension, hyperfiltra- tion, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats 显示文摘 | Tapia E Soto V Ortiz-Vega KM | 2012 | Oxid Med Cell Longev2012，2012，26： | 1 |
| 17 | Risk of venous throm- boembolism during the postpartum period: a systematic re- view显示文摘 | Jackson E Curtis KM Garfield ME | 2011 | Obstet C ~necol2011，117，3： | 1 |
| 18 | A new mechanism for IL-5 dependent helminth control: neutrophil accumulation and neutrophil mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5显示文摘 | Al-Qaoud KM Pearlman E Hartung T | 2000 | Int Immunol2000，12，6： | 1 |
| 19 | Intensive Care Society's APACHE Ⅱstudy in Britain and Ireland Ⅱ : Outcome comparison of intensive care units after adjustment for care mix by the American APACHEⅡ method显示文摘 | Rowan KM Kerr JH Major E | 1993 | BMJ1993，307，： | 1 |
| 20 | Impact of feeding whole Upland cottonseed, with or without cracked Pima cottonseed with increasing addition of iron sulfate, on productivity and plasma gossypol of lactating dairy cattle显示文摘 | McCaughey KM DePeters E J Robinson PH | 2005 | Animal Feed Science and Technology2005，122，34： | 1 |
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