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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | Endoscopic retrograde cholangiopancreatography during pregnancy without radiation显示文摘AIM: To present our experience with pregnant patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) without using radiation, and to evaluate the acceptability of this alternative therapeutic pathway for ERCP during pregnancy. METHODS: Between 2000 and 2008, six pregnant women underwent seven ERCP procedures. ERCP was performed under mild sedoanalgesia induced with pethidine HCl and midazolam. The bile duct was cannulated with a guidewire through the papilla. A catheter was slid over the guidewire and bile aspiration and/or visualization of the bile oozing around the guidewire was used to confirm correct cannulation. Following sphincterotomy, the bile duct was cleared by balloon sweeping. When indicated, stents were placed. Confirmation of successful biliary cannulation and stone extraction was made by laboratory, radiological and clinical improvement. Neither fluoroscopy nor spot radiography was used during the procedure. RESULTS: The mean age of the patients was 28 years (range, 21-33 years). The mean gestational age for the fetus was 23 wk (range, 14-34 wk). Five patients underwent ERCP because of choledocholithiasis and/orcholedocholithiasis-induced acute cholangitis. In one case, a stone was extracted after precut papillotomy with a needle-knife, since the stone was impacted. One patient had ERCP because of persistent biliary fistula after hepatic hydatid disease surgery. Following sphincterotomy, scoleces were removed from the common bile duct. Two weeks later, because of the absence of fistula closure, repeat ERCP was performed and a stent was placed. The fistula was closed after stent placement. Neither post-ERCP complications nor premature birth or abortion was seen. CONCLUSION: Non-radiation ERCP in experienced hands can be performed during pregnancy. Stent placement should be considered in cases for which complete common bile duct clearance is dubious because of a lack of visualization of the biliary tree. | Adem Akcakaya Orhan Veli Ozkan Ismail Okan Orhan Kocaman Mustafa Sahin | 2009 | World Journal of Gastroenterology2009，15，29： | 17 |
| 3 | Clindamycin-induced acute cholestatic hepatitis显示文摘我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU/L (正常范围 0-40 ) ;aspartate aminotransferase (著名计算机生产厂商) , 1337 IU/L (正常范围 5-34 ) ;硷性磷酸酯酶(高山) , 339 IU/L (正常范围 40-150 ) ;gamma-glutamyl transpeptidase (GGT ) , 148 IU/L (正常范围 9-64 IU/L ) ;全部的胆红素, 4.1 mg/dL;直接胆红素, 2.9 mg/dL 和前凝血酶时间(磅) , 13.5 s 与国际规范的比率(INR ) , 1.04。她被就医,与立即的药中止。她的肝活体检视标本显示出混合类型(肝细胞和胆汁郁积的) 肝的损害,与导致药的肝炎的诊断兼容。用 Naranjo 概率规模的一个客观诱发性评价建议 clindamycin 是尖锐肝炎的可能的原因。在易受影响的个人, clindamycin 使用可以导致尖锐混合类型肝毒性。如果在严重肝损伤被建立以前,这药被中止,完全的恢复可能是可能的。 | Cem Aygün Orhan Kocaman Yesim Gürbüz mer Sentürk Sadettin Hülagü | 2007 | World Journal of Gastroenterology2007，13，40： | 6 |
| 4 | Mechanical lithotripsy and/or stenting in management of difficult common bile duct stones显示文摘BACKGROUND:Mechanical lithotripsy and/or stent insertion is the alternative therapeutic approach in difficult endoscopic retrograde cholangiopancreatography (ERCP)case.This study was designed to investigate the appropriate treatment for extraction of bile duct stones in difficult cases of ERCP. METHODS:Between 2000 and 2008,744 ERCP procedures were performed in 592 patients with choledocholithiasis in our endoscopy unit.The demographic features,and clinical and laboratory findings were collected from a prospectively held database.Bile duct calculi were extracted by basket and/or balloon catheter following ERCP and sphincterotomy.Patients with retained stones were regarded as difficult cases.These patients were treated with mechanical lithotripsy and those with incomplete clearance of stones underwent stent placement. RESULTS:Two hundred and forty-five patients(41%) were male and 347(59%)were female with a mean age of 58 years(range 19-95 years).Stones were impacted in 27 patients(5%).Stone extraction was performed by basket and/or balloon catheter in 610 ERCP procedures,and lithotripsy was performed in 70 ERCP procedures.Forty- four patients underwent stent insertion,and 20 underwent stent replacement.Morbidity occurred in 39 patients (5%),with no mortality associated with the procedure.Hemorrhage occurred in 9 patients and basket impaction in 4.Mild pancreatitis and cholangitis developed in 12 and 11 patients,respectively. CONCLUSION:Difficult cases of bile duct stones can be treated successfully with lithotripsy,and a stent should be applied when the common bile duct cannot be cleared completely. | Adem Akcakaya Orhan Veli Ozkan Gurhan Bas Atilla Karakelleoglu Orhan Kocaman Ismail Okan Mustafa Sahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 5 |
| 5 | Calibration and Validation of early ALOS/PRISM Images显示文摘 | GRUEN A KOCAMAN S | 2007 | The Journal of the Japan Society of Photogrammetry and Remote Sensing2007，46，1： | 1 |
| 6 | In vitro evaluation of the genotoxicity of acetamiprid in human peripheral blood lympho- cytes显示文摘 | KOCAMAN A Y TOPAKTAS M | 2007 | Encironmental and Molecular Mutagenesis2007，48，6： | 1 |
| 7 | Psychiatric morbidity andquality of life in patients with chronic idiopathic urticaria显示文摘 | Ozkan M Oflaz SB Kocaman N | 2007 | AnnAllergy Asthma Immunol2007，99，1： | 1 |
| 8 | Absence and Resolution of Fragmented QRS Predict Reversible Myocardial Ischemia With Higher Probability of ST Segment Resolution in Patients With ST Segment Elevation Myocardial Infarction显示文摘 | Cetin M Kocaman SA Kiris T | 2012 | Korean Circ J2012，42，10： | 1 |
| 9 | Relationship between total and differential leukocyte counts and isolated coronary artery ectasia显示文摘 | Kocaman SA Taoy G Sahinarslan A | 2008 | Coron Artery Dis2008，19，5： | 1 |
| 10 | Incremental effects of serum uric acid levels,autonomic dysfunction,and low-grade inflammation on nocturhal blood pressure in untreated hypertensive patients and normotensive individuals显示文摘 | Erden M Kocaman SA Poyraz F | | 0，，07： | 1 |
| 11 | Asymmetric dimethylarginine,NO and collateral growth显示文摘 | Kocaman SA | 2009 | Anadolu Kardiyol Derg2009，9，5： | 1 |
| 12 | A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children显示文摘 | Demiraran Y Kocaman B Akman RY | 2005 | Br J Anaesth2005，95，4： | 1 |
| 13 | Relationship between Nterminal pro-B type natriuretic peptide and extensive echocarciographic parameters in mild to moderate aortic stenosis显示文摘 | Cemri M Arslan U Kocaman SA | 2008 | J Postgrac Med2008，54，1： | 1 |
| 14 | Relationship between to- tal and differential leukocyte counts and isolated coronary artery ecta- sia显示文摘 | Kocaman SA Tacoy G Sahinarslan A | 2008 | Coron Artery Dis2008，19，5： | 1 |
| 15 | Lover gastrointestinal bleeding, hematuria and splenic hemangiomas in Klippel-Trenaunay syndrome: a case report and literature review显示文摘 | Kocaman O Alponat A Aygiin C | 2009 | Turk J Gastroenterol2009，20，1： | 1 |
| 16 | Orientation and selfcalibration of ALOS PRISM imagery 显示文摘 | Kocaman S Green A | 2008 | The Photogrammetric Record2008，23，123： | 1 |
| 17 | Incremental effects of serum uric acid levels,autonomic dysfunction,and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals显示文摘 | ERDEN M KOCAMAN SA POYRAZ F | 2011 | Turk Kardiyol Dern Ars2011，39，7： | 1 |
| 18 | Premature HairWhitening is an Independent Predictor of Carotid Intima ~media Thickness in Young and Middle - aged Men显示文摘 | Erdogan T Kocaman SA Cetin M | 2013 | In-tern Med2013，52，1： | 1 |
| 19 | The use of preoperative lidocaine to prevent stridor and laryngospasm after tonsillectomy and aden-oidectomy显示文摘 | Koc C Kocaman F Aygenc E | 1998 | Otolaryngol Head Neck Surg1998，118，6： | 1 |
| 20 | Relationship between total and differential leukocyte counts and isolated coronary artery ectasia 显示文摘 | KOCAMAN S A TACOY G ' SAHINARSLAN A | 2008 | Coron Artery Dis2008，19，5： | 1 |
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